SignalSilence ® Akt siRNA II from Cell Signaling Technology

Product Specs
ItemSignalSilence ® Akt siRNA II
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6510S
Quantity300 µl
TargetAkt2;Akt3;Akt1
ReactivityH
ApplicationssiRNA
TypesiRNA
NCBI Full Gene NameAKT serine/threonine kinase 3, AKT serine/threonine kinase 2, AKT serine/threonine kinase 1
NCBI Gene AliasesPKB, RAC, PKB-GAMMA, PRKBB, PKB-ALPHA, PRKBA, STK-2, PRKBG, RAC-gamma, HIHGHH, RAC-ALPHA, MPPH2, MPPH, PKBG, AKT, RAC-PK-gamma, RAC-BETA, PKBBETA, PKBB
Research AreaPI3K / Akt Signaling
Molecular Weight60

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma PatientsInternational journal of molecular sciencesJuly 22, 2021Siraj AK, Poyil PK, Parvathareddy SK, Alobaisi K, Ahmed SO, Al-Sobhi SS, Al-Dayel F, Al-Kuraya KS.MMP-2 (13132), MMP-9 (2270), PARP (9542), and cleaved caspase-3 (9664) as well as AKT siRNAs (6211 and 6510) were purchased from Cell Signaling Technologies (Danvers, MA, USA). N-cadherin (ab98952) and Twist

(2) Wear Behavior of Austempered and Quenched and Tempered Gray Cast Irons under Similar HardnessMetalsDecember 8, 2019Bingxu Wang, Xue Han, Gary C. Barber, Yuming Panmin. Each test was repeated times, andtimes, the averages were reported. After the wear an SEM (JSM-6510, JEOL, Tokyo, Japan) three and the averages were reported. After the tests, wear tests, an SEM (JSM-6510, JEOL, Tokyo, equipped EDS

(3) SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expressionThe Biochemical journalJune 29, 2018Biddlestone J, Batie M, Bandarra D, Munoz I, Rocha S.

(4) AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix DeprivationCancer ResearchMarch 15, 2018Manipa Saha, Saurav Kumar, Shoiab Bukhari, Sai A. Balaji, Prashant Kumar, Sravanth K. Hindupur, Annapoorni RangarajanpTRIPZ vector) expression. siRNA oligos against Akt (targeting both isoforms Akt1 and Akt2 [6211 and 6510]) were purchased from Cell Signaling Technology and transfected using oligofectamine (Invitrogen). Pharmacologic

(5) AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix DeprivationCancer Res.January 16, 2018Manipa Saha, Saurav Kumar, Shoiab Bukhari, Sai A. Balaji, Prashant Kumar, Sravanth K. Hindupur, Annapoorni RangarajanpTRIPZ vector) expression. siRNA oligos against Akt (targeting both isoforms Akt1 and Akt2 [6211 and 6510]) were purchased from Cell Signaling Technology and transfected using oligofectamine (Invitrogen). Pharmacologic

(6) Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental ColitisFrontiers in immunologyJanuary 1, 2018Lin N, Shay JES, Xie H, Lee DSM, Skuli N, Tang Q, Zhou Z, Azzam A, Meng H, Wang H, et al.

(7) WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell HomeostasisDevelopmental cellNovember 20, 2017Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, et al.volume of DMSO. For siRNA experiments, 293T cells were transfected with 2 siRNAs against Akt (6211 & 6510, Cell Signaling Technologies) using TransIT-293 Transfection reagent (MIR 6004, Mirus) as per the manufacturer’s

(8) Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cellsOncogeneFebruary 4, 2016Li S, Oh YT, Yue P, Khuri FR, Sun SY.the same as described previously 22. Akt siRNA I (#6211) that targets Akt1 and Akt2 and siRNA II (#6510) that targets Akt1 were purchased from Cell Signaling (Beverly, MA). Transfection of these siRNA duplexes

(9) CR-LAAO antileukemic effect against Bcr-Abl+ cells is mediated by apoptosis and hydrogen peroxideInternational Journal of Biological MacromoleculesJanuary 20, 2016Sandra Mara Burin, Sandro Ghisla, Amanda Tomie Ouchida, Alexandre Ferro Aissa, Maria Gabriela Berzoti Coelho, Tássia Rafaella Costa, Ana Paula Zambuzi Cardoso Marsola, Belinda Pinto-Simões, Lusânia Maria Greggi Antunes, Carlos Curti, Suely Vilela Sampaio, Fabíola Attié de Castro

(10) PI3K/Akt/p53 pathway inhibits reovirus infectionInfection, Genetics and EvolutionAugust 1, 2015Xiaozhan Zhang, Hongxia Wu, Chunguo Liu, Jin Tian, Liandong Qusystem (LI-COR Biosciences). 2.7 Knockdown of PI3K p85α and Akt p85α siRNA (6231, CST), Akt siRNA (6510, CST) and control siRNA (6201, CST) were obtained from Cell Signaling Technology. A549 cells grown in

(11) As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial–mesenchymal transition and activation of AKT signalingCarcinogenesisMay 18, 2012Xin-Jian Li, Li-Xia Peng, Jian-Yong Shao, ?Wen-Hua Lu, Jia-Xing Zhang, Shi Chen, Zhi-Yuan Chen, Yan-Qun Xiang, Ying-Na Bao, Fang-Jing Zheng, Mu-Sheng Zeng, Tie-Bang Kang, Yi-Xin Zeng, Bin Tean Teh, Chao-Nan Qian(siRNA) targeting AKT and a scrambled siRNA were purchased from Cell Signaling Technology (Cat No.: #6510). The target of AKT siRNA is 5′-GCACCTTCATTGGCTACAA-3′, and the siRNA targeting the sequence 5′-CGTACGCGGAATACTTCGA-3′

(12) Activation of PI3K/AKT and MAPK Pathway through a PDGFRÎ²-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular CarcinomaPLoS ONEMarch 9, 2012Quan-Lin Li, Fang-Ming Gu, Zheng Wang, Jia-Hao Jiang, Li-Qing Yao, Chang-Jun Tan, Xiao-Yong Huang, Ai-Wu Ke, Zhi Dai, Jia Fan, et al.regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. J Biol Chem 286(8): 6510–6520. 18. Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211–225. 19.

(13) Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17Nature communicationsJanuary 1, 2011Maretzky T, Evers A, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP.Src, HaCaTs were grown to 40–50% confluency and transfected with 50 nM Stealth siRNA duplex (#6211, #6510, #6564, #6243 or #6568, Cell Signaling Technology, Inc Danvers, MA or sc-29228 Santa Cruz Biotechnology Inc

(14) Human Papillomavirus Type 16 E6/E7 Upregulation of Nucleophosmin Is Important for Proliferation and Inhibition of DifferentiationJournal of VirologyMay 15, 2010Rachel McCloskey, Craig Menges, Alan Friedman, Daksha Patel, Dennis J. McCanceplasmid constructs were sequenced. Small interfering RNAs (siRNAs) targeting AKT (SignalSilence 6211, 6510, and 6511) were purchased from Cell Signaling. siRNAs targeting NPM (sense, UGA UGA AAA UGA GCA CCA

(15) A Myelin Galactolipid, Sulfatide, Is Essential for Maintenance of Ion Channels on Myelinated Axon But Not Essential for Initial Cluster FormationThe Journal of NeuroscienceAugust 1, 2002Tomoko Ishibashi, Jeffrey L. Dupree, Kazuhiro Ikenaka, Yukie Hirahara, Koichi Honke, Elior Peles, Brian Popko, Kinuko Suzuki, Hitoo Nishino, Hiroko BabaCGT-deficient mice. Together, these results indicate that the lack of sulfatide is responsible for 6510 J. Neurosci., August 1, 2002, 22(15):6507–6514 Ishibashi et al. • Myelin Sulfatide Regulates Axonal

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