SignalSilence ® PTEN siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® PTEN siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6251S
Quantity300 µl
TargetPTEN
NCBI Gene Aliases10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1
NCBI Full Gene Namephosphatase and tensin homolog
Research AreaPI3K / Akt Signaling
Molecular Weight54
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) USP13 Suppresses Colorectal Cancer Angiogenesis by Downregulating VEGFA Expression through Inhibition of the PTEN-AKT PathwayOncology ResearchJuly 18, 2025Guo-Zhi Xu, Han-Yang Guan, Yan-Guan Guo, Yi-Ran Zhang, Jing-Hua Pan, Simin Luo, Hui Ding, Yunlong Pan, Qi YaosiRNA (Thermo Fisher Scientific, 284703, Shanghai, China), PTEN siRNA (Cell Signaling Technology, #6251, Shanghai, China) or control siRNA (5′-UUCUCCGAACGUGUCACGUdTdT-3′) transfection by using Lipofectamine

(2) USP13 Suppresses Colorectal Cancer Angiogenesis by Downregulating VEGFA Expression through Inhibition of the PTEN-AKT PathwayOncology researchJanuary 1, 2025Xu GZ, Guan HY, Guo YG, Zhang YR, Pan JH, Luo S, Ding H, Pan Y, Yao Q.siRNA (Thermo Fisher Scientific, 284703, Shanghai, China), PTEN siRNA (Cell Signaling Technology, #6251, Shanghai, China) or control siRNA (5′-UUCUCCGAACGUGUCACGUdTdT-3′) transfection by using Lipofectamine

(3) Glucocorticoid regulation of the mTORC1 pathway modulates CD4+ T cell responses during infectionClinical & Translational ImmunologyAugust 29, 2023Huihui Chen, Zhiwen Liu, Jie Zha, Li Zeng, Runyan Tang, Chengyuan Tang, Juan Cai, Chongqing Tan, Hong Liu, Zheng Dong, et al.siRNA were used following mitogenic stimulation according to the manufacturer's instructions (#6568, #6251 and #6566, Cell Signalling, Danvers, USA). Flow cytometry analysis Flow cytometry was performed as

(4) Retention of Native Quaternary Structure in Racemic Melittin CrystalsJournal of the American Chemical SocietyMay 15, 2019Kathleen W. Kurgan, Adam F. Kleman, Craig A. Bingman, Dale F. Kreitler, Bernard Weisblum, Katrina T. Forest, Samuel H. GellmanKinase Trans-membrane Domains in Cell Signaling and Human Pathologies. Bio-chemistry 2006, 45(20), 6241–6251. (9). Tatulian SA Structural Dynamics of Insulin Receptor and Transmembrane Signaling. Biochemistry 2015,

(5) The RTK Interactome: Overview and Perspective on RTK HeterointeractionsChemical ReviewsMay 8, 2019Michael D. Paul, Kalina HristovaTyrosine Kinase Transmembrane Domains in Cell Signaling and Human Pathologies. Biochemistry 2006, 45, 6241–6251. [PubMed: 16700535] (452). Li E; Hristova K Receptor Tyrosine Kinase Transmembrane Domains: Function,

(6) Evidence for neurogenesis in the medial cortex of the leopard gecko, Eublepharis maculariusScientific reportsJune 25, 2018McDonald RP, Vickaryous MK.

(7) Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomasTheranosticsJanuary 1, 2018Lili Li et al.(#9541), AKT-total (#4691), phospho-AKT(Ser473) (#4060), JAK2 (#9945S), phospho-SAPK/JNK (Thr183/Tyr185) (#6251S), STAT3 (#9139S), phospho-STAT3 (Tyr705) (9145S) and phospho-STAT3 (Ser 727), E-cadherin (#4065) (9134)

(8) Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial gliaScientific ReportsDecember 1, 2017Dillon F. Da Fonte, Christopher J. Martyniuk, Lei Xing, Adrian Pelin, Nicolas Corradi, Wei Hu, Vance L. Trudeau

(9) Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR MiceEvidence-based complementary and alternative medicine : eCAMJanuary 1, 2017Kang JY, Lee DS, Park SK, Ha JS, Kim JM, Ha GJ, Seo WT, Heo HJ.N. Dhanasekaran and E. P. Reddy, “JNK signaling in apoptosis,” Oncogene, vol. 27, no. 48, pp. 6245–6251, 2008. [30] E.-J. Helmreich, The Biochemistry of Cell Signaling, Oxford University Press, New York,

(10) Oxidative stress dependent microRNA-34a activation via PI3Ka reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cellsScientific ReportsOctober 21, 2016J. R. Baker, C. Vuppusetty, T. Colley, Andriana I. Papaioannou, P. Fenwick, Louise Donnelly, K. Ito, P. J. Barnesfor 24 or 48 hours prior to stimulation with H2O2. BEAS2B cells were transfected with siRNA (PTEN # 6251 and FOXO3a #6303 (Cell Signaling Technology), Negative control #1 (Ambion Silencer Select siRNA) (100nM)

(11) Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomainsNature cell biologyJuly 1, 2016Schrul B, Kopito RR.

(12) Characterization of Membrane Protein Interactions in Plasma Membrane Derived Vesicles with Quantitative Imaging FÃ¶rster Resonance Energy TransferAccounts of Chemical ResearchAugust 18, 2015Sarvenaz Sarabipour, Nuala Del Piccolo, Kalina HristovaTyrosine Kinase Transmembrane Domains in Cell Signaling and Human Pathologies. Biochemistry. 2006; 45:6241–6251. [PubMed: 16700535] Acc Chem Res. Author manuscript; available in PMC 2016 August 18. Sarabipour

(13) Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progressionJournal of Clinical InvestigationMarch 1, 2013Rachana Patel et al.stably expressing SPRY2 were selected using geneticin (500 μg/ml; Gibco, Invitrogen). The PTEN siRNA (6251) and p53 siRNA (6562) were obtained from Cell Signaling. The PTEN expression construct (EGFPPTEN) was

(14) miR-122 Regulates p53/Akt Signalling and the Chemotherapy-Induced Apoptosis in Cutaneous T-Cell LymphomaPLoS ONEJanuary 3, 2012Valentina Manfè, Edyta Biskup, Anne Rosbjerg, Maria Kamstrup, Anne Guldhammer Skov, Catharina Margrethe Lerche, Britt Thyssing Lauenborg, Niels Ødum, Robert Gniadeckioverexpression of miR-122. Small Interfering RNA was used at 50 nM for the specific knockdown of PTEN (6251, Cell Signalling, Beverly, MA) and p53 (6231, Cell Signalling). In the case of MyLa2000 cells, transfection

(15) Role of Receptor Tyrosine Kinase Transmembrane Domains in Cell Signaling and Human PathologiesBiochemistryMay 23, 2006Edwin Li, Kalina Hristova21. NIH-PA Author Manuscript Published in final edited form as: Biochemistry. 2006 May 23; 45(20): 6241–6251. doi:10.1021/bi060609y. ROLE OF RECEPTOR TYROSINE KINASE TRANSMEMBRANE DOMAINS IN CELL SIGNALING AND

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