SignalSilence ® SAPK/JNK siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® SAPK/JNK siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6232S
Quantity300 µl
TargetSAPK/JNK1
NCBI Gene AliasesJNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
NCBI Full Gene Namemitogen-activated protein kinase 8
Research AreaMAP Kinase Signaling
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Interleukin-1β induces and accelerates human endometrial stromal cell senescence and impairs decidualization via the c-Jun N-terminal kinase pathwayCell Death DiscoveryJune 15, 2024Robert N. Taylor, Sarah L. Berga, Eric Zou, Jacara Washington, Sunyangzi Song, Brandon J. Marzullo, Indrani C. Bagchi, Milan K. Bagchi, Jie Yudouble-stranded siRNA constructs or a scrambled duplex control purchased from Cell Signaling Technologies (cat# 6232, 6233 and 6568), were introduced into ESC via transient transfection at a concentration of 100 nmol

(2) Mechanism of the Mitogen-Activated Protein Kinases/Mammalian Target of Rapamycin Pathway in the Process of Cartilage Endplate Stem Cell Degeneration Induced by Tension LoadGlobal Spine JournalOctober 1, 2023Yu Zhang, Chen Liu, Yu Li, Hongguang Xudays. Cell Transfection Well-grown CESCs with a cell density of 80% were transfected with JNK-siRNA (#6232, Cell Signaling Technology, Boston, USA), ERK-siRNA (#6560, Cell Signaling Technology), and negative

(3) HMGB1 increases RAGE expression in vascular smooth muscle cells via ERK and p-38 MAPK-dependent pathwaysThe Korean Journal of Physiology & PharmacologySeptember 1, 2022Eun Jeong Jang, Heejeong Kim, Seung Eun Baek, Eun Yeong Jeon, Ji Won Kim, Ju Yeon Kim, Chi Dae Kim(siRNA) preparation and transfection siRNA for p44/42 MAPK (ERK1/2) (Cat # 6560), SAPK/JNK (Cat # 6232) and p38 MAPK (Cat # 6564) were purchased from Cell Signaling Technology. The siRNA negative control

(4) Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathwayFrontiers in pharmacologyJanuary 1, 2022Niu T, Wei Z, Fu J, Chen S, Wang R, Wang Y, Zheng R.ERK phosphorylation) for 30 min, or human Nur77 siRNA (50 nM), JNK1/2 siRNA (Cell signaling, Cat. #6232S, 50 nM), ERK1/2 siRNA (Cell signaling, Cat. #6560S, 50 nM) and HiPerfect transfection reagent (Qiagen,

(5) Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint InfectionInternational journal of molecular sciencesApril 21, 2020Chang Y, Hsiao YM, Hu CC, Chang CH, Li CY, Ueng SWN, Chen MF.Transfection MAPK expression was silenced by small RNA interference. The p38 MAPK siRNA (#6564), JNK siRNA (#6232), and scrambled duplex control siRNA (#6568) were purchased from Cell Signaling Technology (Danvers,

(6) Dual role of RACK1 in airway epithelial mesenchymal transition and apoptosisJournal of cellular and molecular medicineMarch 1, 2020Pu Y, Liu YQ, Zhou Y, Qi YF, Liao SP, Miao SK, Zhou LM, Wan LH.negative control siRNA (NC, sc‐37007) were purchased from Santa Cruz. Double‐stranded JNK siRNA (h, 6232S) and double‐stranded ERK siRNA (h, 6560) were purchased from Cell Signalling Technology. siRNA transfection

(7) microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stressPloS oneJanuary 1, 2019Morii K, Yamasaki S, Doi S, Irifuku T, Sasaki K, Doi T, Nakashima A, Arihiro K, Masaki T.Louis, MO) for 6–24 hours (hrs) and 100–1000 μM paraquat (Sigma-Aldrich) for 24 hrs. ERK (#6560), JNK (#6232), p38 (#6564) and control (#6568) siRNAs were purchased from Cell Signaling Technology (Danvers, MA).

(8) JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in ObesityDiabetesDecember 1, 2017Sara A. Litwak, Lokman Pang, Sandra Galic, Mariana Igoillo-Esteve, William J. Stanley, Jean-Valery Turatsinze, Kim Loh, Helen E. Thomas, Arpeeta Sharma, Eric Trepo, et al.were knocked down transiently in primary hepatocytes using JNK-speciﬁc small interfering RNAs (siRNAs; #6232; Cell Signaling Technology) as described (25); scramble siRNAs were used as a control. Mice Adenovirus

(9) Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced CardiotoxicityMedical Science Monitor : International Medical Journal of Experimental and Clinical ResearchNovember 6, 2017Huolan Zhu, Yan Gao, Shunming Zhu, Qianwei Cui, Jie DuTech), SignalSilence p44/42 (Erk1/2) siRNA (#6560, Cell Signaling Tech) and SignalSilence JNK siRNA (#6232, Cell Signaling Tech) were used to transfect the cells. The scrambled duplex control siRNA (#6568, Cell Signaling

(10) Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced CardiotoxicityMed. Sci. MonitNovember 6, 2017Huolan Zhu, Yan Gao, Shunming Zhu, Qianwei Cui, Jie DuTech), SignalSilence p44/42 (Erk1/2) siRNA (#6560, Cell Signaling Tech) and SignalSilence JNK siRNA (#6232, Cell Signaling Tech) were used to transfect the cells. The scrambled duplex control siRNA (#6568, Cell Signaling

(11) Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosisNature communicationsOctober 24, 2017Chakraborty D, Šumová B, Mallano T, Chen CW, Distler A, Bergmann C, Ludolph I, Horch RE, Gelse K, Ramming A, et al.Eurogentec, Seraing, Belgium) and 100 nM SignalSilence siRNA I for SAPK/JNK (Cell Signaling Technology, #6232). The transfection efficiency was determined by western blot analysis. Non-targeting siRNAs (nt siRNA)

(12) SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetesDiabetologiaMarch 1, 2017Qi W, Li Q, Liew CW, Rask-Madsen C, Lockhart SM, Rasmussen LM, Xia Y, Wang X, Khamaisi M, Croce K, et al.Mek1 (also known as Map2k1) (sc-29396; Santa Cruz, Dallas, TX, USA) and Jnk (also known as Mapk8) (no. 6232; Cell Signaling Beverly, MA, USA) were transfected at 10 nmol/l using Basic Smooth Muscle Cells (SMC)

(13) Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitorsScientific reportsJune 30, 2016Jin HO, Hong SE, Park JA, Chang YH, Hong YJ, Park IC, Lee JK.confocal microscopy (LSM-510, Carl Zeiss, Oberkochen, Germany). siRNAs and transfections The JNK (#6232) and control (#6568) siRNAs were purchased from Cell Signaling Technology (Beverly, MA, USA). Atg5 (sequence:

(14) The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD + Glycohydrolase Induces JNK1-Mediated Programmed Cellular NecrosismBioMarch 2, 2016Sukantha Chandrasekaran, Michael G. CaparonPARP. Knockdown of JNK and PARP was performed with 100 nM of targeting siRNA duplexes (catalog no. 6232 and 6304, respectively; Cell Signaling, Inc., Danvers, MA) delivered as lipid-siRNA complexes using

(15) JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cellsOncotargetJanuary 28, 2016Alejandro Recio-Boiles, Matthias Ilmer, P. Robyn Rhea, Claudia Kettlun, Mitja L. Heinemann, Jennifer Ruetering, Jody Vykoukal, Eckhard Altantibody-FITC Mouse IgG2B and DcR1 antibody-APC Mouse IgG1 (R&D Systems). Small interfering RNA for SAPK/JNK (#6232) and control (#6568) was obtained from SignalSilence ® (Cell Signaling Technologies). MTT assay Cells

(16) Rosuvastatin Attenuates CD40L-Induced Downregulation of Extracellular Matrix Production in Human Aortic Smooth Muscle Cells via TRAF6-JNK-NF-κB PathwayPloS oneJanuary 1, 2016Wang XL, Zhou YL, Sun W, Li L.siRNA (Cat#sc-36717, Santa Cruz, Dallas, TX, USA; 100 nM), ERK1/2 siRNA (Cat#6560), JNK siRNA (Cat#6232), p38 MAPK siRNA (Cat#6564) or NF-κB siRNA (Cat#6261) (all Cell Signaling Technology, Danvers, MA, USA;

(17) Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus ErythematosusJournal of Immunology ResearchMay 19, 2015Genkai Guo, Yan Meng, Wei Tan, Yunfei Xia, Chun Cheng, Xiaolan Chen, Zhifeng GuGUCCAGCUGUUGCGAGAAU. Nontargeting control sequences were not provided. JNK1/2 and PERK siRNA (1, # 6232, 2, # 6233) was purchased from Cell Signaling Technology, Inc. (Danvers, MA) and sequences were not

(18) p75^NTRis highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κBGliaOctober 1, 2014Iram Ahmad, Wei Ying Yue, Augusta Fernando, J. Jason Clark, Erika A. Woodson, Marlan R. HansenTechnologies, Invitrogen, Carlsbad, CA) with siRNA oligonucleotides targeting JNK1 and JNK2 (Cell Signaling, #6232, Beverly, MA), as previously described (Yue et al. 2011). I-JIP (30-100 μM) and SP600125 (20 μM) (both

(19) p38 MAPK regulates the expression of ether à go-go potassium channel in human osteosarcoma cellsRadiology and oncologyMarch 1, 2013Wu X, Zhong D, Lin B, Zhai W, Ding Z, Wu J.dissolved in DMSO as 10 mM stock solution, and stored at −20 °C. p38 MAPK siRNA (#6564), JNK MAPK siRNA (#6232), ERK1/2 MAPK siRNA (#6560) and control siRNA (#6568) were obtained from Cell Signaling Technology®

(20) Induction of apoptosis coupled to endoplasmic reticulum stress in human prostate cancer cells by n-butylidenephthalidePloS oneJanuary 1, 2012Chiu SC, Chen SP, Huang SY, Wang MJ, Lin SZ, Harn HJ, Pang CY.AUAAUGAAGGCCUGACGAA, GUCCAGCUGUUGCGAGAAU. Non-targeting control sequences were not provided. JNK 1/2 siRNA (1, # 6232, 2, # 6233) was purchased from Cell Signaling Technology, Inc. (Danvers, MA) and sequences were not

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