SignalSilence ® Bim siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® Bim siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6461S
NCBI Gene AliasesBAM, BIM, BOD
NCBI Full Gene NameBCL2 like 11
Research AreaApoptosis
Molecular Weight13 BimS, 16 BimL, 23 BimEL
ReactivityH, M, R
ApplicationssiRNA
TypesiRNA
TargetBim
Quantity300 µl

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Tumoricidal efficacy of artesunate-eluting microsphere: differential role of Bax/Bak in orchestration of cell death pathwaysBiomaterials ResearchJune 10, 2025Sarah Helmueller, Sanghee Helmueller, Sanghee Song, Dong-Hyun Song, Dong-Hyun KimLipofectamine 3000 (Thermo Fisher Scientific) and the manufacturer’s protocol. SignalSilence Bim siRNA (#6461) was used (Cell Signaling Technology, Beverly, MA). Cells were treated with siRNA and Lipofectamine

(2) JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD inductionCell death and differentiationOctober 1, 2020Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, Di Daniele A, Caicci F, Caruana I, Soriano ME, et al.have been used: siERK1/2 (Cell Signaling 6560), siJNK1 (Santa Cruz sc-29380), siBim (Cell Signaling 6461), siNEG (Santa Cruz sc-37007) and siBak (Cell Signaling 6486). To generate pEYFP-C1-Drp1-pS616A plasmid

(3) The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cellsPloS oneJanuary 1, 2018Schott CR, Ludwig L, Mutsaers AJ, Foster RA, Wood GA.

(4) Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptorScientific reportsAugust 21, 2017Petta I, Bougarne N, Vandewalle J, Dejager L, Vandevyver S, Ballegeer M, Desmet S, Thommis J, De Cauwer L, Lievens S, et al.

(5) An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in MelanomaCancer ResearchSeptember 15, 2016Jessica L.F. Teh, Timothy J. Purwin, Evan J. Greenawalt, Inna Chervoneva, Allison Goldberg, Michael A. Davies, Andrew E. Aplin(#D-004383-05) siRNAs were purchased from Dharmacon, Inc. (Lafayette, CO). BIRC5 (#6351S and #6546S) and Bim#1 (#6461S) siRNAs were purchased from Cell Signaling. Immunohistochemical analysis 1205Lu xenograft samples

(6) An in vivo reporter to quantitatively and temporally analyze the effects of CDK4/6 inhibitor-based therapies in melanomaCancer Res.August 3, 2016Jessica L.F. Teh, Timothy J. Purwin, Evan J. Greenawalt, Inna Chervoneva, Allison Goldberg, Michael A. Davies, Andrew E. Aplin(#D-004383-05) siRNAs were purchased from Dharmacon, Inc. (Lafayette, CO). BIRC5 (#6351S and #6546S) and Bim#1 (#6461S) siRNAs were purchased from Cell Signaling. Immunohistochemical analysis 1205Lu xenograft samples

(7) Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expressionOncotargetJanuary 19, 2016Li GQ, Guo WZ, Zhang Y, Seng JJ, Zhang HP, Ma XX, Zhang G, Li J, Yan B, Tang HW, et al.(siBim-1) (sc29802) were purchased from (Santa Cruz Biotechnology), the second BIM siRNA (siBim2) (6461) was purchased from Cell Signaling Technology (Shanghai, China), and c-Myc siRNA (siMYC) were purchased

(8) γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cellsBreast cancer research : BCRJune 15, 2012Séveno C, Loussouarn D, Bréchet S, Campone M, Juin P, Barillé-Nion S.after 24 hours. The following siRNAs were used: control siRNA (sc44230) from Santa Cruz, siRNA Bim (6461) from Cell Signaling, siRNA Puma from Dharmacon (Lafayette, USA), siRNA Noxa (AC2Z4U4) from Ambion (Saint

(9) c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1Molecular cancerSeptember 7, 2011Campone M, Noël B, Couriaud C, Grau M, Guillemin Y, Gautier F, Gouraud W, Charbonnel C, Campion L, Jézéquel P, et al.si-Bcl-xL from Dharmacon (L-003458-00), si-Mcl-1 from Ambion (120644), si-Bim from Cell Signaling (6461), si-Puma from Dharmacon (L-004380-00), si-Myc from Santa Cruz (sc-29226), si-Foxo3A from Invitrogen

(10) Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xLCancer ResearchJuly 1, 2011Jue Shi, Yuan Zhou, Hsiao-Chun Huang, Timothy J. Mitchison(J-003305-07) and Bax (J-003308-12) from Dharmacon; Mcl-1 (s120644) and Cdc20 (4392420) from Ambion; Bim (#6461) from Cell Signaling. The above siRNAs were used at final concentration of 20 nM for RNAi in all four

(11) Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xLnihpaMay 5, 2011Jue Shi, Yuan Zhou, Hsiao-chun Huang, Timothy J. Mitchison(J-003305-07) and Bax (J-003308-12) from Dharmacon; Mcl-1 (s120644) and Cdc20 (4392420) from Ambion; Bim (#6461) from Cell Signaling. The above siRNAs were used at final concentration of 20 nM for RNAi in all four

(12) Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibitionPloS oneJanuary 1, 2011Braun F, Bertin-Ciftci J, Gallouet AS, Millour J, Juin P.Biosystem, siBax (60730232) from IDT DNA, siPuma (4380) and siBcl-xL (3458) from Dharmacon and siBim (6461) from Cell Signaling. Cells were transfected using the Hiperfect transfection reagent (QIAGEN) according

(13) "Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation"Clinical cancer research : an official journal of the American Association for Cancer ResearchJanuary 1, 0001"Shi P, Oh YT, Deng L, Zhang G, Qian G, Zhang S, Ren H, Wu G, Legendre B Jr, Anderson E, et al."(21,22). Gene knockdown using small interfering RNA (siRNA) or short hairpin RNA (shRNA) Bim siRNAs I (#6461) and II (#6518) were purchased from Cell Signaling Technology, Inc. Non-silencing control siRNA duplexes

(14) GSK3β and ERK regulate the expression of 78 kDa SG2NA and ectopic modulation of its level affects phases of cell cycleScientific reportsJanuary 1, 0001Pandey S, Talukdar I, Jain BP, Tanti GK, Goswami SK.

(15) Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatmentCancer lettersJanuary 1, 0001"Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, et al."

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