SignalSilence ® GSK-3alpha/beta siRNA from Cell Signaling Technology

Product Specs
ItemSignalSilence ® GSK-3alpha/beta siRNA
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6301S
Quantity300 µl
TargetGSK3-alpha;GSK3-beta
NCBI Full Gene Nameglycogen synthase kinase 3 beta, glycogen synthase kinase 3 alpha
Research AreaPI3K / Akt Signaling
Molecular Weight46
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinomaBiomedicine & PharmacotherapyAugust 1, 2024Silvia Brambillasca, Maria Rosaria Cera, Adrian Andronache, Sumit Kumar Dey, Giovanni Fagá, Daniele Fancelli, Emanuela Frittoli, Maurizio Pasi, Michela Robusto, Mario Varasi, et al.fibronectin-coated glass coverslip; SignalSilence siRNA oligos were from Cell Signaling Technologies (GSK3α/βː #6301; control: #6568). Cells were analyzed 72 h upon transfection, after an overnight incubation with starvation

(2) GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumorsNature communicationsDecember 4, 2018Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang RHY, Ayaz M, Lawrence HR, Kennedy P, Sebti SM.SMARTpool NT siRNA #2 (catalog no. D-001206-14-05; Dharmacon), SignalSilence® GSK3α/β siRNA (catalog no. 6301; Cell Signaling), and SignalSilence® control siRNA (unconjugated; catalog no. 6568; Cell Signaling).

(3) Hyperhomocysteinemia Causes Chorioretinal Angiogenesis with Placental Growth Factor UpregulationScientific reportsOctober 25, 2018Lee YJ, Ke CY, Tien N, Lin PK.

(4) Factors Influencing Business Intelligence Data Collection StrategiesThe Indonesian Journal of Accounting ResearchMay 23, 2017Hanif Faidz Rahadian, Dekar Urumsah4 Loading 0,7640 0,9132 0,9039 0,8863 0,6435 0,7581 0,7616 0,7818 0,8445 0,9431 0,5675 0,8888 Item CST 1 Item CST 2 Item CST 3 Item CST 4 Item OTR 1 Item OTR 2 Item OTR 3 Item OTR 4 0,6301 0,9249 0,8817 0,9825 0,8083 0,9024 0,9089 0,8711 Item PBD 1 Item PBD 2 Item PBD 3 Item PBD 4 Item PBD

(5) 6BIO Enhances Oligonucleotide Activity in Cells: A Potential Combinatorial Anti-androgen Receptor Therapy in Prostate Cancer CellsMolecular TherapyOctober 11, 2016Xiaowei Zhang, Daniela Castanotto, Sangkil Nam, David Horne, Cy Stein

(6) Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-κB PathwayJournal of CancerJanuary 1, 2016Zeng W, Liu Q, Chen Z, Wu X, Zhong Y, Wu J.

(7) The Nav1.2 channel is regulated by GSK3Biochimica et Biophysica Acta (BBA) - General SubjectsApril 1, 2015Thomas F. James et al.control. 2.1.3 Genetic silencing of GSK3 To selectively silence GSK3, siRNA against GSK3 α/β (siRNA 6301, Cell Signaling, Danvers, MA) was obtained in its fluoroscein-conjugated form (gift from Cell Signaling)

(8) Maintaining glycogen synthase kinase-3 activity is critical for mTOR kinase inhibitors to inhibit cancer cell growthCancer researchMay 1, 2014Junghui Koo, Ping Yue, Anthony A Gal, Fadlo R Khuri, Shi-Yong SunGSK-3β (5′-AAGTAATCCACCTCTGGCTAC-3′) siRNAs were synthesized by Qiagen (Valencia, CA). GSK3α/β siRNA (#6301) were purchased from Cell Signaling Technology, Inc. The non-silencing control siRNA duplexes were described

(9) The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosisMolecular cancerNovember 22, 2013Ren H, Koo J, Guan B, Yue P, Deng X, Chen M, Khuri FR, Sun SY.were described previously [16,17]. Small interfering RNA (siRNA) and transfection GSK3α/β siRNA (#6301) was purchased from Cell Signaling Technology. FBXW7 siRNA that targets the sequence of 5′-AACACAAAGCTGGTGTGTGCA-3′

(10) The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosisCancer LettersSeptember 28, 2013Hui Ren, Liqun Zhao, Yikun Li, Ping Yue, Xingming Deng, Taofeek K. Owonikoko, Mingwei Chen, Fadlo R. Khuri, Shi-Yong SunWestern blot analysis using anti-HA antibody (Abgent, San Diego, CA). 2.7, siRNA and transfection GSK3α/β siRNA (#6301) was purchased from Cell Signaling Technology. FBXW7 siRNA that targets the sequence of 5’-AACACAAAGCTGGTGTGTGCA-3’

(11) Glycogen Synthase Kinase 3 Activation Is Important for Anthrax Edema Toxin-Induced Dendritic Cell Maturation and Anthrax Toxin Receptor 2 Expression in MacrophagesInfection and ImmunityAugust 1, 2011Jason L. Larabee, Francisco J. Maldonado-Arocho, Sergio Pacheco, Bryan France, Kevin DeGiusti, Salika M. Shakir, Kenneth A. Bradley, Jimmy D. Ballardmixture was removed and replaced with fresh DMEM containing 10% FBS. The siRNAs against GSK-3 (no. 6301) were purchased from Cell Signaling Technology. As a negative control, cells were transfected with a

(12) SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destructionNatureMarch 3, 2011Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, et al.Skp1 were purchased from Invitrogen (1299003). A GSK3α siRNA oligo (6312) and a GSK3α/β siRNA oligo (6301) were purchased from Cell Signaling. The GSK3β siRNA oligo (51012) was purchased from Ambion. As described

(13) Cyanidin-3-Glucoside Reverses Ethanol-Induced Inhibition of Neurite Outgrowth: Role of Glycogen Synthase Kinase 3 BetaNeurotoxicity ResearchMay 1, 2009Gang Chen, Kimberly A. Bower, Mei Xu, Min Ding, Xianglin Shi, Zun-Ji Ke, Jia Luowas normalized to the levels of actin. GSK3β Small Interfering RNA (siRNA) GSK3β siRNA (Catalog # 6301; Cell Signaling Tech., Inc) was transfected into SK-N-MC cells with oligofectamine reagent (Invitrogen)

(14) A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cellsNature communicationsJanuary 1, 0001"Dagg RA, Zonderland G, Lombardi EP, Rossetti GG, Groelly FJ, Barroso S, Tacconi EMC, Wright B, Lockstone H, Aguilera A, et al."(Thermo Fisher Scientific, 4390824; s6238), siGSK3β (Thermo Fisher Scientific, 4390824; s6241), siGSK3α/β (Cell Signaling, 6301), siMYC SMARTpool (Dharmacon, L-003282-02). AllStars siRNA (Qiagen, 1027281) was used as a negative

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