SignalSilence ® p53 siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® p53 siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6231S
Quantity300 µl
ApplicationssiRNA
Targetp53
Molecular Weight53
ReactivityH
TypesiRNA
NCBI Gene AliasesBCC7, BMFS5, LFS1, P53, TRP53
NCBI Full Gene Nametumor protein p53
Research AreaCell Cycle / Checkpoint Control

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Nicotine-Induced VEGF Levels in NSCLC Cells Are Modulated by PKA, Hyaluronan, and p53International Journal of Molecular SciencesNovember 17, 2025Caroline Wozniak, Alvaro Cobos, Aya Sabri, Stuti Goel, Brooke Lopo, Sarah Sarofim, Chanidapa Chutipassakul, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans(H + L) secondary antibody (HRP, 31466) were purchased from ThermoFisher. SignalSilence p53 siRNA I (6231), SignalSilence control siRNA (unconjugated, 6568), PKA C-α (D38C6) rabbit mAb #5842, and p53 rabbit

(2) Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survivalFEBS Open BioSeptember 23, 2025Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evanssecondary antibody (HRP, 31466) were from Thermo Fisher, Waltham, MA, USA. SignalSilence p53 siRNA I (6231), SignalSilence control siRNA (Unconjugated, 6568), and p53 rabbit antibody (9282) were purchased from

(3) Downregulation of EZH2 promotes renal epithelial cellular senescence and kidney agingFASEB JMay 15, 2025Yingying Zhang, Chen Yu, Ewud Agborbesong, Xiaogang Liplasmid transfection The RNA oligonucleotides that specifically targeted human EZH2 (#6509) and human p53 (#6231) were purchased from Cell signaling Technology Inc. The RNA oligonucleotides were transfected with the

(4) Downregulation of EZH2 Promotes Renal Epithelial Cellular Senescence and Kidney AgingThe FASEB JournalMay 15, 2025Yingying Zhang, Chen Yu, Ewud Agborbesong, Xiaogang Liplasmid transfection The RNA oligonucleotides that specifically targeted human EZH2 (#6509) and human p53 (#6231) were purchased from Cell signaling Technology Inc. The RNA oligonucleotides were transfected with the

(5) Regulation of Vascular Endothelial Growth Factor Signaling by Nicotine in a Manner Dependent on Acetylcholine-and/or β-Adrenergic-Receptors in Human Lung Cancer CellsCancersNovember 21, 2023Al Khashali H, Darweesh B, Ray R, Haddad B, Wozniak C, Ranzenberger R, Goel S, Khalil J, Guthrie J, Heyl D, et al.purchased from R&D Systems. SignalSilence Control siRNA (Unconjugated, 6568), SignalSilence p53 siRNA I (6231), and p53 antibody (9282) were from Cell Signaling Technology. 2.2. Cell Culture Human NSCLC cell

(6) Opposing Roles of IGFBP-3 and Heparanase in Regulating A549 Lung Cancer Cell SurvivalCellsNovember 8, 2022Al Khashali H, Wareham J, Ray R, Haddad B, Coleman KL, Ranzenberger R, McCombs P, Guthrie J, Heyl D, Evans HG.m-IgGκ BP-HRP was obtained from Santa Cruz Biotechnology (Dallas, TX, USA). SignalSilence p53 siRNA I (6231), SignalSilence Control siRNA (Unconjugated, 6568), and p53 antibody (9282) were purchased from Cell Signaling Technology

(7) Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppressioneLifeSeptember 20, 2022Ann Rancourt, Sachiko Sato, Masahiko S Satoh(human),A549-luc-C8,Xenogen Corporation,N/A, Sequence-based reagent,p53 siRNA I,Cell Signaling Technology,6231, Sequence-based reagent,Control siRNA,Cell Signaling Technology,6568, "Software, algorithm","MetaMorph

(8) Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppressionElifeSeptember 20, 2022Ann Rancourt, Sachiko Sato, Masahiko S Satoh(human),A549-luc-C8,Xenogen Corporation,N/A, Sequence-based reagent,p53 siRNA I,Cell Signaling Technology,6231, Sequence-based reagent,Control siRNA,Cell Signaling Technology,6568, "Software, algorithm","MetaMorph

(9) Differences in the Relative Abundance of ProBDNF and Mature BDNF in A549 and H1299 Human Lung Cancer Cell MediaInternational journal of molecular sciencesJune 30, 2021Dorandish S, Atali S, Ray R, Al Khashali H, Coleman KL, Guthrie J, Heyl D, Evans HG.luminol (chemiluminescence) reagent were from Pierce (Waltham, MA, USA). SignalSilence p53 siRNA I (6231), SignalSilence Control siRNA (Unconjugated, 6568), and p53 antibody (9282) were purchased from Cell Signaling Technology

(10) Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinomaeLifeJune 9, 2020Hastings JF, Gonzalez Rajal A, Latham SL, Han JZ, McCloy RA, O'Donnell YE, Phimmachanh M, Murphy AD, Nagrial A, Daneshvar D, et al.,Cell Signaling Technology,#6572, Transfected construct (human),SignalSilence p53 siRNA I,Cell Signaling Technology,#6231, Transfected construct (human),SignalSilence p53 siRNA II,Cell Signaling Technology,#6562, Sequenced-based

(11) 4-Hydroxy-7-oxo-5-heptenoic acid (HOHA) lactone induces apoptosis in retinal pigment epithelial cellsFree radical biology & medicineMay 20, 2020Linetsky M, Guo J, Udeigwe E, Ma D, Chamberlain AS, Yu AO, Solovyova K, Edgar E, Salomon RG.anti-human p-JNK1/JNK2 (Tyr 183/Tyr185; CST #9255) and p53 duplex (SignalSilence p53 siRNA I, CST #6231), scrambled duplex siRNA (SignalSilence Control siRNA, unconjugated, #6568) were obtained from Cell Signaling Technology

(12) IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent MannerScientific reportsMarch 19, 2020Price D, Muterspaugh R, Clegg B, Williams A, Stephens A, Guthrie J, Heyl D, Evans HG.super signal west pico luminol (chemiluminescence) reagent were from Pierce. SignalSilence p53 siRNA I (6231), SignalSilence Control siRNA (Unconjugated, 6568), p53 antibody (9282) were purchased from Cell Signaling Technology

(13) Annexin A2 Silencing Inhibits Proliferation and Epithelial-to-mesenchymal Transition through p53-Dependent Pathway in NSCLCsJournal of CancerJanuary 29, 2019Minhua Wu, Yanqin Sun, Feipeng Xu, Yanqing Liang, Hao Liu, Yanmei Yiby puromycin (1 μg/mL). The small-interfering RNA (siRNA) targeting p53 (SignalSilence® p53 siRNA I #6231) were from Cell Signaling Technology (USA). A549 cells were plated into 6-well plate at a density of

(14) Rotundic acid induces Cas3-MCF-7 cell apoptosis through the p53 pathwayOncology lettersJanuary 1, 2019Nan ML, Wang X, Li HJ, Yu DH, Sun WY, Xu HM, He YF, Zhao QC.small interfering RNA (siRNA) reagent kit were purchased from Cell Signaling Technology, Inc (catalog no. 6231, Danvers, MA, USA). Dulbecco's modified Eagle's medium (DMEM), trypsin, fetal bovine serum (FBS), PBS,

(15) RIOK1 kinase activity is required for cell survival irrespective of MTAP statusOncotargetJune 19, 2018Alexandra Hörmann et al.

(16) Bufadienolides induce p53-mediated apoptosis in esophageal squamous cell carcinoma cells inï¿½vitro and inï¿½vivoOncology LettersNovember 21, 2017Shaohuan Lin, Junhong Lv, Panli Peng, Changqing Cai, Jianming Deng, Haihong Deng, Xuejun Li, Xinyue Tanggrow to 60% confluence after 24 h. The cells were then incubated with p53 siRNA (100 nmol/l; cat. no. 6231; Cell Signaling Technology, Inc.) in serum-free DMEM for 24 h, with Lipofectamine® 2000 (cat. no. 11668027;

(17) Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cellsJournal of Experimental & Clinical Cancer Research : CRSeptember 8, 2017Xiaomin Feng, Hao Liu, Zhijie Zhang, Yixue Gu, Huisi Qiu, Zhimin He(Annexin A2 siRNA-3). The small-interfering RNA (siRNA) targeting p53 (SignalSilence® p53 siRNA I #6231) were from Cell Signaling Technology (Beverly, MA, USA). A549/DDP cells were plated into 6-well plate

(18) Suppression of p53 potentiates chemosensitivity in nutrient-deprived cholangiocarcinoma cells via inhibition of autophagyOncology lettersAugust 1, 2017Hu F, Guo XL, Zhang SS, Zhao QD, Li R, Xu Q, Wei LX.investigated. The cell lines QBC939 and RBE were treated with 20 µM PFT-α or transfected with p53-siRNA (6231; Cell Signaling Technology, USA), then cultured for 24 h in FN or NF medium. A CCK-8 assay revealed

(19) Inhibition of Colon Carcinoma Cell Migration Following Treatment with Purified Venom from Lesser Weever Fish (Trachinus Vipera)Cellular Physiology and BiochemistryJanuary 1, 2017Myriam Fezai, Chaker Slaymi, Mossadok Ben-Attia, Guido Kroemer, Florian Lang, Mohamed Jemaàunrelated siRNA (siUNR) or with a specific siRNA directed against p53 (SignalSilence p53 siRNA I, #6231, Cell Signaling Technology, Billerica, MA) by means of lipofectamine RNAiMAX transfection reagent (Thermo Fisher Scientific

(20) Functional Analyses of the Crohn's Disease Risk Gene LACC1PloS oneJanuary 1, 2016Assadi G, Vesterlund L, Bonfiglio F, Mazzurana L, Cordeddu L, Schepis D, Mjösberg J, Ruhrmann S, Fabbri A, Vukojevic V, et al.

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