SignalSilence ® Tuberin/TSC2 siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® Tuberin/TSC2 siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6476S
Quantity300 µl
TargetTuberin/TSC2
NCBI Gene AliasesLAM, PPP1R160, TSC4
NCBI Full Gene NameTSC complex subunit 2
Research AreaPI3K / Akt Signaling
Molecular Weight200
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavageCell Commun SignalMay 31, 2025Hugo E. Verdejo, Valentina Parra, Andrea Del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, et al.for Oma-1 and negative control (Mission, Sigma-Aldrich Corp.) and siRNA against Tsc2 (SignalSilence 6476, Cell Signaling) were used following the manufacturer’s instructions. The siRNAs used for knockdown

(2) Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTORCell death & diseaseJuly 12, 2022Lee B, Park SJ, Lee S, Lee J, Lee E, Yoo ES, Chung WS, Sohn JW, Oh BC, Kim S.After lomitapide treatment, the plate was incubated at 5% CO2 at 37 °C for 24 h. siTSC2 (SignalSilence #6476; Cell Signaling Technology), siPLD1 (5′-AAGGUGGGACGACAAUGAGCA-3’), siPLD2 (5′-AAGAGGUGGCUGGUGGUGAAG-3′)

(3) Hypoxia-inducible transgelin 2 selects epithelial-to-mesenchymal transition and γ-radiation-resistant subtypes by focal adhesion kinase-associated insulin-like growth factor 1 receptor activation in non-small-cell lung cancer cellsCancer scienceNovember 1, 2018Kim IG, Lee JH, Kim SY, Hwang HM, Kim TR, Cho EW.

(4) The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesisScientific reportsJune 28, 2018Chang CC, Huang YS, Lin YM, Lin CJ, Jeng JC, Liu SM, Ho TL, Chang RT, Changou CA, Ho CC, et al.

(5) SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanomaOncotargetJanuary 26, 2018Puglisi R, Bellenghi M, Pontecorvi G, Gulino A, Petrini M, Felicetti F, Bottero L, Mattia G, Carè A.

(6) Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transitionNucleic acids researchApril 20, 2017Zangari J, Ilie M, Rouaud F, Signetti L, Ohanna M, Didier R, Roméo B, Goldoni D, Nottet N, Staedel C, et al.

(7) Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor CellsMolecular cancer research : MCRDecember 1, 2015Gao Y, Gartenhaus RB, Lapidus RG, Hussain A, Zhang Y, Wang X, Dan HC.duplexes that target the indicated mRNA. siRNA to human TSC2-(2) was from Cell Signaling Technology (CST-6476). siRNA to human Raptor was from Dharmacon. siRNA to rat Akt1, Akt2, Raptor, Rictor and ERK and siRNA

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