m7G(5)ppp(5)G RNA Cap Structure Analog from New England Biolabs

Product Specs
Itemm7G(5)ppp(5)G RNA Cap Structure Analog
CompanyNew England Biolabs
Price $174.00 Inquire
Catalog NumberS1404S
Quantity1 µmol
ApplicationsFunctional Genomics
Temperature-20 C

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New England Biolabs

240 County Road

Ipswich, Massachusetts 1938

United States

Phone: 800-632-5227
800-632-7799
978-921-1350

Company Profile

Website: http://www.neb.com

(1) Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic lifeCellFebruary 17, 2026J. Maximilian Fels, Aidan B. Hill, Richard Han, Jasmine M. Garcia, Hugo Bisio, Chantal Abergel, Philip J. Kranzusch, Amy S.Y. Lee7-Methylguanosine 5′-triphosphate sodium salt,Sigma Aldrich,Cat#M6133 m7G(5’)ppp(5’)G RNA Cap Structure Analog,NEB,Cat#S1404S m7G(5’)ppp(5’)A RNA Cap Structure Analog,NEB,Cat#S1405S m7GP3C,Jena Biosciences,Cat#NU-512S GTP,NEB,Cat#N0450L PEI

(2) Principles of cotranslational mitochondrial protein importCellOctober 2, 2025Zikun Zhu, Saurav Mallik, Taylor A. Stevens, Riming Huang, Emmanuel D. Levy, Shu-ou ShanEDTA-free Protease Inhibitor Cocktail",Sigma,11873580001 m7G(5’)ppp(5’)G RNA Cap Structure Analog,NEB,S1404S "Proteinase K, recombinant",Sigma,3115879001 ,, Critical commercial assays,Critical commercial assays,Critical

(3) Synergically enhanced anti-tumor immunity of in vivo panCAR by circRNA vaccine boostingCell Reports MedicineAugust 19, 2025Yanyan Wang, Liangru Lin, Xinyue Wang, Jing Li, Qian Pan, Haomeng Kou, Jie Yin, Fei Gao, Xinyuan Liao, Chenchen Zhang, et al."RNase Inhibitor, Murine",New England Biolabs,Cat#M0314L m7G(5′)ppp(5′)G RNA Cap Structure Analog,New England Biolabs,Cat#S1404S C12-200,AVT,Cat#CK0239 Percoll cell isolation solution,GE (Pharmacia),Cat#17089102 ACK Lysis Buffer,Solarbio,Cat#R1010 DOPE,AVT,Cat#S03005 ELISA

(4) Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosisCellular and Molecular Life SciencesDecember 1, 2024Jing-Cai Liu, Zhen-Nan Pan, Jia-Qian Ju, Yuan-Jing Zou, Meng-Hao Pan, Yue Wang, Xin Wu, Shao-Chen Suncondition was 37 °C, 2 h. mRNA synthesis was performed using m7G(5′)ppp(5′)G (New England Biolabs, S1404S) and HiScribe T7 high-yield RNA synthesis kit (New England Biolabs, E2040S, MA, USA). The reaction system

(5) Mutation of the SUMOylation site of Aurora-B disrupts spindle formation and chromosome alignment in oocytesCell death discoveryOctober 22, 2024Chen SS, Li L, Yao B, Guo JL, Lu PS, Zhang HL, Zhang KH, Zou YJ, Luo NJ, Sun SC, et al.HiScribe T7 High Yield RNA Synthesis Kit (NEB, E2040S) and capping it with m7G (5′) ppp (5′) G (NEB, S1404S) and E. coli poly (A) polymerase added to the poly(A) tail (Beyotime, R7070s). Finally, the mRNA was

(6) The role of IBV PL1pro in virus replication and suppression of host innate immune responsesBMC Vet ResDecember 13, 2023Weirong Liu, Ge Mu, Yiquan Jia, Mengting Yu, Songbai Zhang, Zhen Wang, Shouguo FangSystems-T7 (Promega, USA) and supplemented with a cap structure m7G(5’)ppp(5’)G RNA Cap Structure Analog (S1404S, New England Biolabs, USA). Finally, the capped full-length RNA and IBV-N transcripts were subjected

(7) Evolution of naturally arising SARS-CoV-2 defective interfering particlesCommunications biologyOctober 27, 2022Girgis S, Xu Z, Oikonomopoulos S, Fedorova AD, Tchesnokov EP, Gordon CJ, Schmeing TM, Götte M, Sonenberg N, Baranov PV, et al.SP6 RNA Polymerase (NEB, #M0207S) and co-transcriptionally capped with m7GpppG RNA Cap Analog (NEB, #S1404S). Nuclease-treated rabbit reticulocyte lysate (RRL) (Promega, #L4960) was programmed with 20 ng/µL mRNA

(8) PABP/purine-rich motif as an initiation module for cap-independent translation in pattern-triggered immunityCellAugust 18, 2022Wang J, Zhang X, Greene GH, Xu G, Dong X.#304–93521 "Amino Acid Mixture, Complete",Promega,Cat. #L4461 m7G(5′)ppp(5′)G RNA Cap Structure Analog,NEB,Cat. #S1404S SUPERase•In RNase Inhibitor,Invitrogen,Cat. #AM2694 RiboLock RNase Inhibitor,Thermo Scientific,Cat.

(9) Multi-step recognition of potential 5' splice sites by the Saccharomyces cerevisiae U1 snRNPeLifeAugust 12, 2022Sarah R Hansen, David S White, Mark Scalf, Ivan R CorrÃªa, Lloyd M Smith, Aaron A Hoskins2013",, "Chemical compound, drug",m7G(5’)ppp(5’)G RNA Cap Structure Analog,New England BioLabs,Cat. No. S1404S, "Chemical compound, drug",AMV Reverse Transcriptase,Promega,Cat. No. M5101, "Chemical compound, drug",RnaseH

(10) Circular RNA vaccines against SARS-CoV-2 and emerging variantsCellMay 12, 2022Qu L, Yi Z, Shen Y, Lin L, Chen F, Xu Y, Wu Z, Tang H, Zhang X, Tian F, et al."RNase Inhibitor, Murine",APExBIO,Cat#K1046 m7G(5')ppp(5')G RNA Cap Structure Analog,New England Biolabs,Cat#S1404S ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, SARS-CoV-2 Spike RBD Protein ELISA kit

(11) Splice site m⁶A methylation prevents binding of U2AF35 to inhibit RNA splicingCellJune 10, 2021Mendel M, Delaney K, Pandey RR, Chen KM, Wenda JM, Vågbø CB, Steiner FA, Homolka D, Pillai RS.fragments were purified and used for T7 transcription with an m7G cap analog (m7G(5)ppp(5)G, NEB, Cat. No. S1404S) used in 4:1 ratio to GTP. Using m7G analog is essential as only capped transcripts are efficiently

(12) A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19SLAS DiscoveryJune 1, 2021Sumera Perveen, Aliakbar Khalili Yazdi, Kanchan Devkota, Fengling Li, Pegah Ghiabi, Taraneh Hajian, Peter Loppnau, Albina Bolotokova, Masoud Vedadiwere purchased from bioSYNTHESIS (Levisville, TX). The unlabeled Cap RNA, m7G(5′)ppp(5′G (NEB, cat. S1404S) and m7G(5′)ppp(5′)A (NEB, cat. S1405S), also referred to as N7-meGpppG and N7-meGpppA for consistency,

(13) METTL3/METTL14 Transactivation and m⁶A-Dependent TGF-β1 Translation in Activated Kupffer CellsCellular and molecular gastroenterology and hepatologyJanuary 1, 2021Feng Y, Dong H, Sun B, Hu Y, Yang Y, Jia Y, Jia L, Zhong X, Zhao R.Transcripts with noncap, nonfunctional (ApppG) cap (S1407S; New England Biolabs), and normal (m7G) cap (S1404S; New England Biolabs) were generated using the T7 High Yield Transcription Kit (TR101-01; Vazyme, Nanjing,

(14) Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine MetabolismCell Chemical BiologyJune 1, 2020Qi Liu, Amita Gupta, Ayse Okesli-Armlovich, Wenjie Qiao, Curt R. Fischer, Mark Smith, Jan E. Carette, Michael C. Bassik, Chaitan KhoslaMEGAscript T7 Transcription Kit,Invitrogen,Cat#AM1334 m7G(5')ppp(5')G RNA Cap Structure Analog,New England BioLabs,Cat#S1404S CellTiter-Glo,Promega,Cat#G7570 Renilla-Glo,Promega,Cat#E2710 Renilla,Promega,Cat#E2820 ,, Experimental Models

(15) Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4FCell ReportsFebruary 25, 2020Jennifer Chu et al.T7 RNA polymerase,New England Biolabs,Cat#: M0251L m7G(5′)ppp(5′)G RNA cap structure analog,New England Biolabs,Cat#: S1404S G(5′)ppp(5′)A RNA Cap Structure Analog,New England Biolabs,Cat#: S1406S AMP-PNP,Sigma-Aldrich,Cat#:

(16) Inosine induces context-dependent recoding and translational stallingNucleic acids researchJanuary 10, 2019Licht K, Hartl M, Amman F, Anrather D, Janisiw MP, Jantsch MF.incubator to prevent evaporation using 10 mM of ITP instead of GTP and 2 mM of m7G cap analog (NEB #S1404S) followed by DNaseI digestion (Thermo Fisher Scientific, MA, Waltham, #EN0521) using 5 units. 400 ng

(17) Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T CellsMolecular TherapyApril 1, 2017Daniel T. MacLeod, Jeyaraj Antony, Aaron J. Martin, Rachel J. Moser, Armin Hekele, Keith J. Wetzel, Audrey E. Brown, Melissa A. Triggiano, Jo Ann Hux, Christina D. Pham, Victor V. Bartsevich, Caitlin A. Turner, Janel Lape, Samantha Kirkland, Clayton W. Beard, Jeff Smith, Matthew L. Hirsch, Michael G. Nicholson, Derek Jantz, Bruce McCreedy

(18) Structural mutants of dengue virus 2 transmembrane domains exhibit host-range phenotypeVirology JournalDecember 1, 2011Katherine M Smith, Kavita Nanda, Carla J Spears, Mariana Ribeiro, Ricardo Vancini, Amanda Piper, Gwynneth S Thomas, Malcolm E Thomas, Dennis T Brown, Raquel Hernandez(Promega) following manufacturer's instructions, with the addition of RNA cap analog 7 mg(ppp)G (NEB # S1404S). The RNA transcripts were transfected into Vero and C6/36 cells as follows: Cells were pelleted and

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