PC-12 from ATCC

Product Specs
ItemPC-12
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberCRL-1721
ApplicationsThis cell line is a suitable transfection host
TypeCell Biology
SpeciesRattus norvegicus
TissueAdrenal gland
Cell LinePC-12
Validated Species ReactivityRat (Rt)
Tissue (standardized)Adrenal Gland
DiseasePheochromocytoma

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer ProgressionCancer DiscoveryMay 1, 2026Jérémy Nigri, Wenjun Lan, Melanie L. Fung, Charlotte Kayser, Astrid Deschênes, Juliene Hinds, Sanjeev Kaushalya, Sara A. Pawlak, Jennifer S. Thalappillil, Sandeep Nadella, et al.maintained in DMEM supplemented with 10% FBS, as previously described (25) The PC12 rat cell line (ATCC CRL-1721, RRID:CVCL_0481) was cultured in RPMI 1640 medium (Corning, 10–040-CV) supplemented with 10% heat-inactivated

(2) Myofibroblasts induce neuroplasticity to promote pancreatic inflammation and cancer progressionCancer DiscovMay 1, 2026Jérémy Nigri, Wenjun Lan, Melanie L. Fung, Charlotte Kayser, Astrid Deschênes, Juliene Hinds, Sanjeev Kaushalya, Sara A. Pawlak, Jennifer S. Thalappillil, Sandeep Nadella, et al.maintained in DMEM supplemented with 10% FBS, as previously described (25) The PC12 rat cell line (ATCC CRL-1721, RRID:CVCL_0481) was cultured in RPMI 1640 medium (Corning, 10–040-CV) supplemented with 10% heat-inactivated

(3) Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cellsEndocr Relat CancerApril 22, 2026Yasmine Kemkem, Mark Quinn, Bence Kövér, Alice Santambrogio, James Kaufman-Cook, Olivia Sherwin, Laura D Scriba, Dimitria Brempou, Miriam Vazquez Segoviano, Dylan Cameron, et al.line generation To generate a stable PC12 cell line in which Sox2 is overexpressed, PC12 cells (CAT# CRL-1721, ATCC, USA) were co-transfected with the (PB)TetO-SOX2_2xNLS-eGFP and a PiggyBac transposase plasmid

(4) The Activation of Aldehyde Dehydrogenase 2 (ALDH2) by Alda-1 and Flurbiprofen as a Common Mechanism to Reduce Alcohol Intake in RatsInt J Mol SciApril 3, 2026Juan Manuel Torres, Carolina Ponce, Vicente Pérez, Ignacio Gutiérrez-Vega, María Elena Quintanilla, David Vásquez, Mario Rivera-Mezato animals. 4.3. Exposure of PC-12 Cell Cultures to Drugs Rat pheochromocytoma PC-12 cells (ATCC CRL-1721) were used to assess in vitro the effects of drugs on ALDH2 activity. PC-12 cells were grown in Roswell

(5) Multi-platform profiling reveals host- and cell -type-specific pseudorabies virus gene expressionScientific ReportsApril 1, 2026Balázs Kakuk, Zsolt Csabai, Zoltán Deim, Gábor Torma, Ádám Fülöp, Gergely Ármin Nagy, Virág Éva Dani, Dóra Tombácz, Zsolt BoldogkőiCRL-6509), the C6 cell line derived from a rat glial tumor (ATCC CCL-107), and the PC-12 cell line (ATCC CRL-1721) derived from a pheochromocytoma of the rat adrenal medulla, which has an embryonic origin from the

(6) Docosahexaenoic Acid Modulates Autophagy and Confers Neuronal Resilience under Hypoxia-Reoxygenation StressJ Mol NeurosciMarch 30, 2026Francis Zamora, Manuel L. Montero, Jo-Wen Liu, Viet Hoang Dinh, Johnny D. Figueroa, Marino A. De Leónbuffers. Cell Culture and Differentiation PC12 cells (rat pheochromocytoma; RRID: CVCL_0481, ATCC Cat# CRL-1721) were cultured on poly-L-lysine–coated six-well plates in F-12 K medium containing 15% horse serum,

(7) Role of the Glycine Transporter GlyT2 in the Neuronal Differentiation of PC12 CellsInternational Journal of Molecular SciencesMarch 26, 2026Jorge Sarmiento-Jiménez, Beatriz Morales-González, Enrique Núñez, Elena Martínez-Blanco, Francisco Zafra, Francisco Javier Díez-Guerra, Beatriz López-Corcuerapersonalized therapeutic relevance. 4. Materials and Methods 4.1. Cell Culture PC12 cells (ATCC CRL-1721, Manassas, VA, USA) kindly provided by Dr. J. Diez-Guerra (CBM, Madrid, Spain) were maintained in Roswell

(8) Synthetic serum markers enable noninvasive monitoring of gene expression in primate brainsNeuronFebruary 27, 2026Sangsin Lee, McKenna D. Romac, Sho Watanabe, Mykyta Chernov, Honghao Li, Emma Raisley, Kathryn M. Rothenhoefer, Zachary Dahlquist, Jerzy O. Szablowski, Vincent D. Costaquantities and kept on wet ice during surgery until they were injected. PC-12 transduction PC-12 (ATCC #CRL-1721) was cultured in RPMI 1640 medium (Corning #10–040-CV) supplemented with 10% horse serum (Life Technologies

(9) A Time-Resolved RNA-Sequencing Dataset of Transcriptional Responses in PC12 cells to NGF Withdrawal and ReplenishmentData in BriefFebruary 26, 2026Peter Neufeld, Eliza Grlickova-Duzevik, Benjamin J. Harrisonreplenishment. 4 Experimental Design, Materials and Methods PC12 cells were purchased from ATCC (CRL-1721) and maintained per manufacturer protocol in growth media containing RPMI01640 media (ATCC, 30-2001)

(10) Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic DamageAdvanced ScienceFebruary 16, 2026Wenhui Wang, Yongrui Hai, Xintong Lu, Ye Chen, Bingjie Zhang, Renming Fan, Jiarui Dou, Jiaxin Yan, Shuo Fu, Wen Zhang, et al.CVCL_0493) were purchased on March 1, 2023. PC12 (rat adrenal medullary pheochromocytoma cells, ATCC, CRL‐1721, RRID: CVCL_0481) were purchased on August 7, 2023. They were cultured in Dulbecco's Modified Eagle's Medium (DMEM

(11) Multidimensional transcriptome dataset for systematic evaluation of Jakyakgamcho-tang-induced cell signaturesScientific DataFebruary 6, 2026Su-Jin Baek, Haeseung Lee, Sang-Min Park, Aeyung Kim, No Soo Kim, Eun-Hye Seo, A Yeong Lee, Yu Ri Kim, Wook Jin Kim, Kyu-Won Seo, et al.(P/S). Cultures were incubated at 37 °C in a humidified atmosphere with 5% CO2. The PC12 cells (ATCC CRL-1721) were cultured on 100 mm collagen I-coated culture dishes (Coning BioCoat, Corning Inc., NY, USA) in

(12) Sodium Nitroprusside as a Xenobiotic Model of Oxidative and Nitrosative Stress in Cellular and Zebrafish SystemsJournal of XenobioticsFebruary 6, 2026Carlos Alberto-Silva, Felipe Assumpção da Cunha e Silva, Brenda Rufino da da Silva, Leticia Ribeiro de de Barros, Adolfo Luis Almeida Maleski, Maricilia Silva CostamHippoE-18 cells (CLU199, CELLutions Biosystems, Toronto, ON, Canada) and rat pheochromocytoma PC12 cells (CRL-1721™, ATCC, Manassas, VA, USA). The mHippoE-18 cells were cultured in high-glucose Dulbecco’s Modified Eagle

(13) Thymol carbamates bearing cyclic amines as potent and selective BuChE inhibitors alleviate memory impairments for Alzheimer's disease therapyJ Enzyme Inhib Med ChemFebruary 6, 2026Chengyao Wu, Yulu Ding, Xiaodan Liu, Shan Gao, Xiaoqing Wang, Wenjian Tangindependent experiments. Neuroprotective study PC12 (rat adrenal pheochromocytoma cells, CVCL-0481, ATCC CRL-1721), obtained from Procell Life Science and Technology Co., Ltd. (China), were seeded into 96-well plates

(14) A Ru(ii)-arene complex with promising anti-Aβ activityRSC AdvFebruary 2, 2026Ryan M. Hacker, Jacob J. Smith, David C. Platt, Maria I. Loughlin, Emma N. Grabowski, William W. Brennessel, Marjorie A. Jones, Michael I. Webb(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay using adherent Rattus norvegicus pheochromocytoma cells (PC-12; ATCC CRL-1721) and axenic Rattus norvegicus C6 glioma cells (ATTC CCL-107) following previous procedures.15 Results

(15) The role of parasite-produced dopamine in Toxoplasma gondii-altered host behaviourNat CommunDecember 5, 2025Beatriz Calvo-Urbano, Maya Kaushik, An-Chi Cheng, Greg C. Bristow, Emese Prandovszky, Martin Walker, Poppy H. L. Lamberton, Glenn A. McConkey, Joanne P. Websterstrain). Dopamine levels were then quantified in vitro via infected and uninfected rat PC12 cells (ATCC CRL-1721). Two replicate overexpression (OE) lines were uniquely selected here to represent contrasting levels

(16) Allocryptopine, tetrahydropalmatine, and tetrahydroberberine N-oxide alkaloids alleviate cellular stress by modulating calcium homeostasis and the MAPK and akt/GSK-3β/tau signaling pathwaysFrontiers in PharmacologyNovember 25, 2025Serap Nigdelioglu Dolanbay, Belma AslimPC12 cell line used in the study The cells used in the study are the pheochromocytoma-12 (PC12, ATCC® CRL-1721™) cell line obtained from Rattus norvegicus and derived from rat adrenal medulla. PC12 cells were grown

(17) eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet TransplantationSmallNovember 18, 2025Manju Shrestha, Yeonji Kim, Subin Park, Hu‐Lin Jiang, Jae‐Young Lee, Daesik Kim, Jee‐Heon JeongLiu. Cell Culture and Transfection Gesicle Producer 293T cells (Takara Bio, 632617) and PC12 cells (ATCC, CRL‐1721) were cultured in Dulbecco's Modified Eagle Medium (DMEM; Welgene) supplemented with 10% fetal bovine serum (FBS

(18) Co‐localization of tau and TDP ‐43 after extracellular vesicle delivery to cellsThe FEBS JournalNovember 17, 2025Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strongmethods HEK293 (no.: CRL‐1573; ATCC, Gaithersburg, MD, USA), SH‐SY5Y (no.: CRL‐2266; ATCC) and PC12 (no.: CRL‐1721; ATCC) cells were from ATCC and derived from low passage (< 5) frozen stocks. All cells used in the

(19) Neuronal conversion of single-chain tissue-type plasminogen activator into its two-chain form: implications in neurodevelopment, learning, and memoryCell Death & DiseaseNovember 7, 2025Hortense Triniac, Simon Lebatard, Valerie Roussel, Charlotte Lechevallier, Laurent Lebouvier, Denis Vivien, Benoit D. Rousselcells reached full confluency (7-9 DIV). PC-12 culture PC-12 cells (rat adrenal gland cell line, CRL-1721, ATCC) were grown in RPMI-1640 (11875093, Gibco) supplemented with 12.5% HS and 2.5% FBS (Supplementary

(20) Secretome from Uterine Cervical Mesenchymal Stem Cells as a Protector of Neuronal Cells Against Oxidative Stress and InflammationBiomoleculesOctober 2, 2025Javier Mateo, Miguel Ángel Suárez-Suárez, Maria Fraile, Ángel Ramón Piñera-Parrilla, Francisco J. Vizoso, Noemi Eiroadrenal medulla, were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA; CRL-1721). Cells were plated (40,000 cells/well) in a 24-well plate with collagen I (Gibco, Carlsbad, CA, USA;

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PC-12 from ATCC

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