PC-12 from ATCC

Product Specs
ItemPC-12
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberCRL-1721
TypeCell Biology
SpeciesRattus norvegicus
TissueAdrenal gland
Cell LinePC-12
Validated Species ReactivityRat (Rt)
Tissue (standardized)Adrenal Gland
DiseasePheochromocytoma
ApplicationsThis cell line is a suitable transfection host

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) A biodegradable piezoelectric vertebral implant for programmable electro-neuromodulation in spinal cord injurySci AdvAugust 7, 2026Penghao Liu, Xinyu Wang, Yanchun Liu, Zhuofan Xu, Yana He, Yongchang Lu, Liguo Ye, Wenjing Wu, Zan Chen, Yushu Wang, et al.extended accordingly. Piezo Gel stimulated by US in vivo and in vitro Neuronal cell line PC12 (ATCC No. CRL1721) and Schwann cell line RSC96 (ATCC, CRL2765) were cultured in 24-well plates. For the assessment of

(2) Neuroprotective and Antidepressant Effects of Tenebrio molitor Larvae Hydrolysate in LPS-induced Neuroinflammation ModelsExperimental NeurobiologyJune 30, 2026Younsoo Byun, Jiaxiang Zheng, Yoonhwa Jeong, Jihyun NohAlcalase® was used for further experiments. Cell culture and treatment condition PC-12 cells (ATCC CRL-1721; American Type Culture Collection, Manassas, VA, USA) were cultured in RPMI-1640 medium (Cat #SH30027.01;

(3) Transmission Electron Microscopy of Cultured Cells: Optimized Protocols for Ultrastructural Studies and Post-embedding Immunogold LabelingBiology Methods and ProtocolsJune 15, 2026Anna Richert, Robert Lenartowski, Jolanta Nowak, Piotr Wasąg, Marta Lenartowskaneuroscience for investigating neuronal differentiation (American Type Cell Culture Collection, ATCC, CRL-1721). General solutions and reagents Culture media dedicated to cell lineDulbecco’s Phosphate Buffered

(4) Enhancing Dopamine Accumulation in Secretory Vesicles of PC12 Cells: Mechanisms, Applications and LimitationsJ NeurochemJune 4, 2026Noemi Socas-Pérez, Ricado Borges, José David Machadosources (i.e., the American Type Culture Collection, ATCC). On one hand, the parental PC12 cells (i.e., CRL1721), which grow mainly in suspension as small, irregularly shaped and floating cell clusters. They tend

(5) Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer ProgressionCancer DiscoveryMay 1, 2026Jérémy Nigri, Wenjun Lan, Melanie L. Fung, Charlotte Kayser, Astrid Deschênes, Juliene Hinds, Sanjeev Kaushalya, Sara A. Pawlak, Jennifer S. Thalappillil, Sandeep Nadella, et al.maintained in DMEM supplemented with 10% FBS, as previously described (25) The PC12 rat cell line (ATCC CRL-1721, RRID:CVCL_0481) was cultured in RPMI 1640 medium (Corning, 10–040-CV) supplemented with 10% heat-inactivated

(6) Myofibroblasts induce neuroplasticity to promote pancreatic inflammation and cancer progressionCancer DiscovMay 1, 2026Jérémy Nigri, Wenjun Lan, Melanie L. Fung, Charlotte Kayser, Astrid Deschênes, Juliene Hinds, Sanjeev Kaushalya, Sara A. Pawlak, Jennifer S. Thalappillil, Sandeep Nadella, et al.maintained in DMEM supplemented with 10% FBS, as previously described (25) The PC12 rat cell line (ATCC CRL-1721, RRID:CVCL_0481) was cultured in RPMI 1640 medium (Corning, 10–040-CV) supplemented with 10% heat-inactivated

(7) Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cellsEndocr Relat CancerApril 22, 2026Yasmine Kemkem, Mark Quinn, Bence Kövér, Alice Santambrogio, James Kaufman-Cook, Olivia Sherwin, Laura D Scriba, Dimitria Brempou, Miriam Vazquez Segoviano, Dylan Cameron, et al.line generation To generate a stable PC12 cell line in which Sox2 is overexpressed, PC12 cells (CAT# CRL-1721, ATCC, USA) were co-transfected with the (PB)TetO-SOX2_2xNLS-eGFP and a PiggyBac transposase plasmid

(8) BUB1 as a candidate non-oncogene addiction vulnerability in metastatic phaeochromocytoma/paragangliomaScientific ReportsApril 21, 2026Marziehsadat Ahmadi, Seyed Jalal Zargar, Hussam Alkaissi, Hans K. Ghayee, Karel Pacak, Pouria Jandaghi, Daniel Aulddescribed elsewhere25,26. The PC12 cell line, from a rat phaeochromocytoma, was obtained from ATCC (CRL-1721). All three cell lines were cultured in DMEM medium (Gibco, 10313-021, Thermo Fisher Scientific, USA)

(9) The Activation of Aldehyde Dehydrogenase 2 (ALDH2) by Alda-1 and Flurbiprofen as a Common Mechanism to Reduce Alcohol Intake in RatsInt J Mol SciApril 3, 2026Juan Manuel Torres, Carolina Ponce, Vicente Pérez, Ignacio Gutiérrez-Vega, María Elena Quintanilla, David Vásquez, Mario Rivera-Mezato animals. 4.3. Exposure of PC-12 Cell Cultures to Drugs Rat pheochromocytoma PC-12 cells (ATCC CRL-1721) were used to assess in vitro the effects of drugs on ALDH2 activity. PC-12 cells were grown in Roswell

(10) Multi-platform profiling reveals host- and cell -type-specific pseudorabies virus gene expressionScientific ReportsApril 1, 2026Balázs Kakuk, Zsolt Csabai, Zoltán Deim, Gábor Torma, Ádám Fülöp, Gergely Ármin Nagy, Virág Éva Dani, Dóra Tombácz, Zsolt BoldogkőiCRL-6509), the C6 cell line derived from a rat glial tumor (ATCC CCL-107), and the PC-12 cell line (ATCC CRL-1721) derived from a pheochromocytoma of the rat adrenal medulla, which has an embryonic origin from the

(11) Docosahexaenoic Acid Modulates Autophagy and Confers Neuronal Resilience under Hypoxia-Reoxygenation StressJ Mol NeurosciMarch 30, 2026Francis Zamora, Manuel L. Montero, Jo-Wen Liu, Viet Hoang Dinh, Johnny D. Figueroa, Marino A. De Leónbuffers. Cell Culture and Differentiation PC12 cells (rat pheochromocytoma; RRID: CVCL_0481, ATCC Cat# CRL-1721) were cultured on poly-L-lysine–coated six-well plates in F-12 K medium containing 15% horse serum,

(12) Role of the Glycine Transporter GlyT2 in the Neuronal Differentiation of PC12 CellsInternational Journal of Molecular SciencesMarch 26, 2026Jorge Sarmiento-Jiménez, Beatriz Morales-González, Enrique Núñez, Elena Martínez-Blanco, Francisco Zafra, Francisco Javier Díez-Guerra, Beatriz López-Corcuerapersonalized therapeutic relevance. 4. Materials and Methods 4.1. Cell Culture PC12 cells (ATCC CRL-1721, Manassas, VA, USA) kindly provided by Dr. J. Diez-Guerra (CBM, Madrid, Spain) were maintained in Roswell

(13) Synthetic serum markers enable noninvasive monitoring of gene expression in primate brainsNeuronFebruary 27, 2026Sangsin Lee, McKenna D. Romac, Sho Watanabe, Mykyta Chernov, Honghao Li, Emma Raisley, Kathryn M. Rothenhoefer, Zachary Dahlquist, Jerzy O. Szablowski, Vincent D. Costaquantities and kept on wet ice during surgery until they were injected. PC-12 transduction PC-12 (ATCC #CRL-1721) was cultured in RPMI 1640 medium (Corning #10–040-CV) supplemented with 10% horse serum (Life Technologies

(14) A Time-Resolved RNA-Sequencing Dataset of Transcriptional Responses in PC12 cells to NGF Withdrawal and ReplenishmentData in BriefFebruary 26, 2026Peter Neufeld, Eliza Grlickova-Duzevik, Benjamin J. Harrisonreplenishment. 4 Experimental Design, Materials and Methods PC12 cells were purchased from ATCC (CRL-1721) and maintained per manufacturer protocol in growth media containing RPMI01640 media (ATCC, 30-2001)

(15) Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic DamageAdvanced ScienceFebruary 16, 2026Wenhui Wang, Yongrui Hai, Xintong Lu, Ye Chen, Bingjie Zhang, Renming Fan, Jiarui Dou, Jiaxin Yan, Shuo Fu, Wen Zhang, et al.CVCL_0493) were purchased on March 1, 2023. PC12 (rat adrenal medullary pheochromocytoma cells, ATCC, CRL‐1721, RRID: CVCL_0481) were purchased on August 7, 2023. They were cultured in Dulbecco's Modified Eagle's Medium (DMEM

(16) Multidimensional transcriptome dataset for systematic evaluation of Jakyakgamcho-tang-induced cell signaturesScientific DataFebruary 6, 2026Su-Jin Baek, Haeseung Lee, Sang-Min Park, Aeyung Kim, No Soo Kim, Eun-Hye Seo, A Yeong Lee, Yu Ri Kim, Wook Jin Kim, Kyu-Won Seo, et al.(P/S). Cultures were incubated at 37 °C in a humidified atmosphere with 5% CO2. The PC12 cells (ATCC CRL-1721) were cultured on 100 mm collagen I-coated culture dishes (Coning BioCoat, Corning Inc., NY, USA) in

(17) Thymol carbamates bearing cyclic amines as potent and selective BuChE inhibitors alleviate memory impairments for Alzheimer's disease therapyJ Enzyme Inhib Med ChemFebruary 6, 2026Chengyao Wu, Yulu Ding, Xiaodan Liu, Shan Gao, Xiaoqing Wang, Wenjian Tangindependent experiments. Neuroprotective study PC12 (rat adrenal pheochromocytoma cells, CVCL-0481, ATCC CRL-1721), obtained from Procell Life Science and Technology Co., Ltd. (China), were seeded into 96-well plates

(18) Sodium Nitroprusside as a Xenobiotic Model of Oxidative and Nitrosative Stress in Cellular and Zebrafish SystemsJournal of XenobioticsFebruary 6, 2026Carlos Alberto-Silva, Felipe Assumpção da Cunha e Silva, Brenda Rufino da da Silva, Leticia Ribeiro de de Barros, Adolfo Luis Almeida Maleski, Maricilia Silva CostamHippoE-18 cells (CLU199, CELLutions Biosystems, Toronto, ON, Canada) and rat pheochromocytoma PC12 cells (CRL-1721™, ATCC, Manassas, VA, USA). The mHippoE-18 cells were cultured in high-glucose Dulbecco’s Modified Eagle

(19) A Ru(ii)-arene complex with promising anti-Aβ activityRSC AdvFebruary 2, 2026Ryan M. Hacker, Jacob J. Smith, David C. Platt, Maria I. Loughlin, Emma N. Grabowski, William W. Brennessel, Marjorie A. Jones, Michael I. Webb(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay using adherent Rattus norvegicus pheochromocytoma cells (PC-12; ATCC CRL-1721) and axenic Rattus norvegicus C6 glioma cells (ATTC CCL-107) following previous procedures.15 Results

(20) The role of parasite-produced dopamine in Toxoplasma gondii-altered host behaviourNat CommunDecember 5, 2025Beatriz Calvo-Urbano, Maya Kaushik, An-Chi Cheng, Greg C. Bristow, Emese Prandovszky, Martin Walker, Poppy H. L. Lamberton, Glenn A. McConkey, Joanne P. Websterstrain). Dopamine levels were then quantified in vitro via infected and uninfected rat PC12 cells (ATCC CRL-1721). Two replicate overexpression (OE) lines were uniquely selected here to represent contrasting levels

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PC-12 from ATCC

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