Octet® R4 System from Sartorius

Product Specs
ItemOctet® R4 System
CompanySartorius
Price Get Pricing Get Quote for this Product
Catalog Number30-0514
TypeProtein Analysis System
ApplicationsBioprocessing, Cell Line Development, ELISA, Process Development, Screening, Small Molecules, QC & Manufacturing, Vaccine
ThroughputUp to 4 assays in parallel
Weight72 lb (or 32.7 kg)
Dimensions(WxDxH) 22 x 18.2 x 19.5 in. (or 56 x 46 x 49 cm)
QuantityEA
Sample Volume180–220 µL/well Nondestructive testing
Sample TypeProteins, antibodies, peptides, DNA, RNA, liposomes, viruses and VLPs in various media including serum, buffers containing DMSO, periplasmic fractions, untreated cell culture supernatants, and crude cell lysates
Plate FormatsStandard 96-well, black, flat-bottom microplate

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Local Office

Sartorius

5 Orville Drive

Bohemia, NY 11716

United States

Company Profile

International Office

Sartorius

Otto-Brenner-Straße 20

37079 Göttingen

Germany

Phone: +49 551 308 0

Company Profile

Website: www.sartorius.com

(1) De-repression of protein phosphatase 5 by the chaperone organizer HOP1 activates plant NLR immunityNat PlantsApril 8, 2026Yan Yan, Zhixue Zhao, In-Cheol Yeo, Jun Liu, Luciano de Souza Vespoli, Guangchao Liu, Suji Ye, Jayakrishnan Nandakumar, Libo Shan, Ping Hewhich corresponds to the enzymatic activity. BLI assays BLI measurements were performed using the Octet R4 platform (Sartorius Bioanalytical Instruments) with Octet BLI Discovery version 13.0. The BLI assay

(2) Engineered interfaces in Rac1 and Cdc42 biosensors enhance sensitivity and reduce cell perturbationMolecular Biology of the CellApril 1, 2026Daniel J. Marston, Ellen C. O'Shaughnessy, Timothy M. Jacobs, Jaewon Huh, Denis Tsygankov, Mingyu Choi, Xiao Ma, Mihai L. Azoitei, Gaudenz Danuser, Brian Kuhlman, et al.between GTPases and affinity reagents, binding was measured by Biolayer Interferometry (BLI) on an Octet R4 instrument (Sartorius) using AR2G biosensors. The target affinity reagents were coupled to the biosensors

(3) A high-affinity split-HaloTag for live-cell protein labelingNat CommunMarch 25, 2026Yin-Hsi Lin, Julian Kompa, De-En Sun, Runyu Mao, Birgit Koch, Konstantin Hinnah, Jonas Wilhelm, Natascha Franz, Stefanie Kühn, Tanja Menche, et al.bio-layer interferometry Bio-layer interferometry (BLI) analysis was performed in a 96-well plate using an Octet® R4 system (Sartorius) with an acquisition rate for standard kinetics of 5.0 Hz at 25 °C. Chemically synthesized

(4) Crystal Structure of Měnglà Virus Nucleoprotein Bound by a Poorly Cross-Reactive Anti-Marburg Virus Nanobody Highlights a Single Amino Acid Affinity Switch, a Feature Also Evident in Dehong VirusACS Infectious DiseasesMarch 13, 2026Laura Jo Sherwood, Alexander Bryan Taylor, Shaun K. Olsen, Andrew HayhurstCurves are plots of the mean RLU, minus nLuc-only controls, and ±SD. Biolayer Interferometry (BLI) An Octet R4 (Sartorius, Göttingen, Germany) was used to examine the interaction between sdAb A (ligand) and the

(5) Identification of novel pyrazolo[4,3-c]pyridine and diazepane derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase BInfection and ImmunityMarch 10, 2026Raunak Raunak, Aayush Bahl, Shubham Srivastava, Roopshali Rakshit, Shivani Bansal, Sashi Kant, Chandi C. Mandal, Saurabh Pandey, Deeksha Tripathianalysis Binding kinetics between PtpB-Mtb and the identified lead compounds were analyzed using a Sartorius BLI Octet R4 system with dip and read Ni-NTA biosensors pre-immobilized with novel nickel charged Tris-NTA (46). The biosensors

(6) Celafolin A-1 Ameliorates Subretinal Fibrosis via Inhibition of Crystallin Alpha B in a Laser-Induced Choroidal Neovascularization Mouse ModelBiomolecules & TherapeuticsMarch 1, 2026Eunhye Yu, Sun Mi Gu, Haechan Kim, Jun Gu Kim, Bang Yeon Hwang, Jung Kee Min, Jaesuk Yunsurface (Abdiche et al., 2008; Concepcion et al., 2009). In this study, BLI was employed using the Octet R4 system (Sartorius, Göttingen, Germany) along with Ni-NTA biosensors to assess the binding kinetics between

(7) Evaluation of molecular interactions of vaping juice components with ACE2 receptorScientific ReportsFebruary 21, 2026Samavath Mallawarachchi, Aayushi Nangia, Mohammad Jasim Ibrahim, Aadhil Haq, Sandun Fernando, Maria D. Kingfree energy. Biolayer interferometry Biolayer interferometry (BLI) was conducted using the Sartorius Octet R4 BLI Label-Free Detection system (Sartorius, Ann Arbor, MI). Aminopropylsilane (APS, Sartorius) biosensors

(8) Mechanisms of DNA methyltransferase 3A1 mediated DNA methylation of nucleosomesJournal of Biological ChemistryFebruary 20, 2026Ethan Ward, Drew McDonald, Tyler Holl, Norbert Reichconfidence interval. Biolayer interferometry assay Real-time monitoring of DNMT3A1 binding DNA and nucleosomes was done on an Octet R4 BLI system (Sartorius) using streptavidin (SA) biosensors (Sartorius). All assays were performed in

(9) A Mammalian Surface Display Platform to Optimize the Antigenicity of Viral Proteins for Vaccine DesignbioRxivJanuary 15, 2026Jayani Christopher, Caitlin Harris, Daniel J. Marston, Brianna Rhodes, McKenzie Frazier, Mihai L. AzoiteiFusion sCMOS camera (Hamamatsu). Binding studies using biolayer interferometry (BLI) A Sartorius Octet R4 instrument was used to measure binding of H3/Hong Kong 1968 to a panel of antibodies (VNO1H1, FluA-20,

(10) Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodiesNature CommunicationsDecember 6, 2025Arden Darko-Boateng, Emmanuel Afriyie, Travis J. Morgenstern, Sri Karthika Shanmugam, Xinle Zou, Yianni D. Laloudakis, Papiya Choudhury, Meera Desai, Robert S. Kass, Francesca Vallese, et al.WW4-HECT(NEDD4-2) (analyte). The binding kinetics of nb.C11 were assessed using the 4-Channel System: Octet® R4 (Sartorius). After an initial equilibration step of 60 sec, HIS-tagged nb.C11 at 50 nmol/L in buffer

(11) Iterative immunogen optimization to focus immune responses on a conserved, subdominant viral epitopebioRxivNovember 10, 2025Daniel J. Marston, Akiko Watanabe, A. Brenda Kapingidza, Caitlin Harris, Elizabeth Van Itallie, Kapil Devkota, Jayani Christopher, Peiying Liu, Beena Pun, Brianna Rhodes, et al.www.graphpad.com). Binding by Surface Plasmon Resonance (SPR) / Biolayer Interferometry (BLI). A Sartorius Octet R4 instrument was used to measure binding of HA220 variants to a panel of antibodies (FluA-20, S1V2-58,

(12) Immunofocusing design of a fusion glycoprotein monomer vaccine for respiratory syncytial virusMolecular TherapyNovember 5, 2025Qianqian Li, Zhiming Li, Jiamin Chen, Qiuju He, Hongjian Xiao, Haiwei Li, Huan Li, Heng Zhang, Yaoyun Yang, Rong Bi, et al.antibodies competition analysis of immunized sera by BLI All BLI experiments were performed on an Octet R4 instrument (Sartorius). DS-Cav1 was diluted to 20 μg/mL in a phosphate buffer containing 2% BSA and

(13) Generation of novel human anti-OX-40 mAbs endowed with different biological properties as tools for cancer therapyFrontiers in ImmunologySeptember 17, 2025Rosa Rapuano Lembo, Margherita Passariello, Lorenzo Manna, Guendalina Froechlich, Martina Belardo, Alfredo Nicosia, Emanuele Sasso, Claudia De Lorenzoanalyze the kinetics of the four purified anti-OX-40 mAbs, BLI analyses were performed by using the Octet R4 Protein Analysis System (Sartorius, Fremont, CA, USA) by following the manufacturer’s recommendation,

(14) Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOPNat CommunAugust 5, 2025Sagar Batra, Francisco Olmo, Timothy J. Ragan, Merve Kaplan, Valeria Calvaresi, Asger Meldgaard Frank, Claudia Lancey, Mahya Assadipapari, Cuifeng Ying, Weston B. Struwe, et al.interferometry Binding of anti-TcPOP mAbs to TcPOP was measured by kinetic experiments carried out on an Octet R4 (Sartorius). All samples were buffer exchanged into Sartorius Kinetics Buffer, according to the manufacturer’s

(15) Isolation of a Monoclonal Human scFv Against Cytomegalovirus pp71 Antigen Using Yeast DisplayAntibodies (Basel)July 10, 2025Kazuhisa Aoki, Rikio Yabe, Sayaka Ono, Mayumi Saeki, Yuri Tanno, Hidetaka Tannomicroplates (Sigma Aldrich, St. Louis, MO, USA, #781608) at 30 °C with shaking at 1000 rpm using an Octet R4 instrument (Sartorius, Göttingen, Germany) and anti-penta-His (HIS1K) biosensors (Sartorius, #18-5120).

(16) Development of antibodies against severe fever with thrombocytopenia syndrome virus nucleoprotein for diagnosisAppl Microbiol BiotechnolJune 7, 2025Eun-Mee Park, Seheon Kim, Seoyoen Lim, Parastou Rahimizadeh, Hyeyoon Jeon, Hyung Jin Lim, Sungjin Lee, Yong Bhum Songat least three times. Data are expressed as mean ± SD. Bio-layer interferometry kinetic assay The Octet R4 Protein Analysis System (Sartorius, Göttingen, Niedersachsen, Germany) was used for the bio-layer interferometry

(17) Aptamer Development for SARS-CoV-2 and Omicron Variants Using the Spike Protein Receptor Binding Domain as a Potential Diagnostic Tool and Therapeutic AgentBiomoleculesJune 1, 2025Prasanna V. Shekar, Anuj Kumar, Nirmitee Mulgaonkar, Samneet Kashyap, Gourav Choudhir, Sandun Fernando, Sachin Rustgiresuspended and stored as per the manufacturer’s instructions. The BLI experiments were performed in the Octet R4 instrument (Sartorius, Göttingen, Germany) using the Octet BLI Discovery 12.2 Software. Binding experiments

(18) A Novel Human Anti-FV mAb as a Potential Tool for Diagnostic and Coagulation Inhibitory ApproachesInt J Mol SciMarch 18, 2025Margherita Passariello, Rosa Rapuano Lembo, Lorenzo Manna, Ciro Miele, Antonello Merlino, Cristina Mazzaccara, Antonio Leonardi, Claudia De Lorenzonovel D9 mAb for Human Factor Va, Factor Xa, and Factor VIIIc, BLI analyses were performed by using the Octet R4 Protein Analysis System (Sartorius, Fremont, CA, USA). Biosensors carrying the protein A (18-5010, Octet

(19) In Silico Evaluation of Potential Hit Molecules Against Multiple Serotypes of Dengue Virus Envelope GlycoproteinMoleculesMarch 12, 2025Aadhil Haq, Samavath Mallawarachchi, Aiden Anderson, Leily Khaleghi, Lasan Manujitha, Sandun Fernandoand binding kinetics of the compounds were assessed using BLI. The experiments were conducted on an Octet R4 (Sartorius, Bohemia, NY, USA) instrument with a 96-well plate. The Octet Anti-Penta-HIS (HIS1K) biosensor

(20) Emodin mitigates rheumatoid arthritis through direct binding to TNF-αFrontiers in PharmacologyFebruary 26, 2025Dingyan Lu, Xudong Tian, Taotao Cao, Shuaishuai Chen, Chunhua Liu, Lin Zheng, Meng Zhou, Xiaoyan Peng, Yongjun Li, Ting Liuand the data acquisition and analysis were performed using the Octet BLI Discovery analysis software (Octet ® R4, Sartorius, Germany). 2.12 Molecular dynamics simulation The protein structures of TNF-α (PDB IDs:

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Octet® R4 System

Octet® R4 System from Sartorius

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Sartorius

Sartorius

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Octet® R4 System from Sartorius

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