HCC827 from ATCC

Product Specs
ItemHCC827
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberCRL-2868
TypeCell Biology
SpeciesHomo sapiens
TissueLung
Cell LineHCC827
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Lung
Cell Typeepithelial cell
Age39 years
DiseaseAdenocarcinoma

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancerNat CommunApril 15, 2026Yapeng Su, Chunmei Liu, Xiang Lu, Hui-Yu Chuang, Guideng Li, Shiqun Shao, Yan Kong, Jihoon W. Lee, Rachel H. Ng, Stephanie Wong, et al.short-term experiments, M397 and M229 cells were exposed to 3 µM and 10 µM VEM, respectively. HCC827 (CRL-2868) and HT-29 (HTB-38) were purchased from ATCC and cultured in ATCC-formulated RPMI-1640 Medium (ATCC

(2) Fusariumic Acids I and J, Two New Phytotoxic Isocassadiene-Type Diterpenoids from Tomato Fusarium Crown and Root Rot Pathogen Fusarium oxysporum f. sp. radicis-lycopersiciToxins (Basel)April 3, 2026Prosper Amuzu, Gan Gu, Xuwen Hou, Jiahang Sun, Muhammad Abubakar Jakada, Eromosele Odigie, Daowan Lai, Ligang Zhouhepatocellular carcinoma cell line (ATCC number: CL1353), PC-9 lung adenocarcinoma cell line (ATCC number: CRL-2868), and PANC1 pancreatic carcinoma cell line (ATCC number: CRL-1469) as a panel of human cancer cell lines.

(3) A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistanceNature CommunicationsMarch 3, 2026Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Ipek S. Gokulu, Sophia R. Abrahamson, Lila Taylor, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, et al.RRID:CVCL_0063), U-2 OS (ATCC - HTB-96™, RRID:CVCL_0042), BT20 (ATCC - HTB-19™, RRID:CVCL_0178), HCC827 (ATCC - CRL 2868, RRID:CVCL_2063), SYF KO (ATCC - CRL-2459, RRID:CVCL_6461), and SV40 immortalized Mouse embryonic fibroblast—MEFs

(4) The Crosstalk Mechanism of EGFR and ER in EGFR-Mutant Lung AdenocarcinomaCellsJanuary 6, 2026Ying-Yi Chen, Wei-Ting Huang, Yu-Fu Su, Yi-Jen Hung, Hao-Ai Shui, Yi-Shing Shieh, Tsai-Wang HuangCulture Conditions The non-small cell lung cancer (NSCLC) lines PC9 (ECACC 90071810) and HCC827 (ATCC CRL-2868) were used as models harboring EGFR exon 19 deletion mutations. The Taiwanese lung adenocarcinoma cell

(5) Allele-specific knockdown by an engineered DNAzyme capable of RNase H1 evasionNucleic Acids ResearchJanuary 6, 2026Erica M Lee, Kim Nguyen, Noah A Setterholm, Turnee N Malik, John C Chaputpurchased from ATCC: NCI-H441 lung adenocarcinoma (Cat# ATCC-CRM-HTB-174), HCC827 lung adenocarcinoma (Cat# CRL-2868), SW620 colorectal adenocarcinoma (Cat# CCL-227), HeLa cervical adenocarcinoma (Cat# CCL-2),and MCF7

(6) NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancersNatureJanuary 1, 2026Jinho Jeong, Simone Hausmann, Hanyang Dong, Kacper Szczepski, Natasha M. Flores, Andy Garcia Garcia Gonzalez, Liyang Shi, Xiaoyin Lu, Joanna Lempiäinen, Moritz Jakab, et al.male, 27 years old, NSCLC), NCI-H1975 (ATCC, CRL-5908, female, age not reported, NSCLC), HCC827 (ATCC, CRL-2868, female, 39 years old, NSCLC), PC9 (RIKEN, RCB4445, sex and age not reported, NSCLC), NCI-H2228 (ATCC,

(7) Integration of a novel anti-PD-1 antibody with chimeric antigen receptor-T engineered to express interleukin-7 enhances targeting efficacy against lung cancerLife MedicineDecember 23, 2025Chenxi Cheng, Lin Zhang, Jiani Cao, Xiaoyan Li, Ya Wen, Kun Liu, Tongbiao Zhaostudy included HEK293T, human lung adenocarcinoma cell lines A549 (ATCC, CCL-185), and HCC827 (ATCC, CRL-2868), all obtained from ATCC. These were cultured in Dulbecco’s Modified Eagle Medium (DMEM) supplemented

(8) EMB ‐01, a Tetravalent Bispecific Antibody, Inducing Co‐Degradation of EGFR and c‐Met for Enhanced Anti‐Tumor EfficacyCancer ScienceDecember 12, 2025Jing Gao, Xi Jiao, Fang Ren, Xuan Wu, Jingyun Tan, Yuezong Bai, Yan Dai, Lixia Shen, Chengbin Wu, Lin ShenCellular Cytotoxicity (ADCC) and Complement‐Dependent Cytotoxicity (CDC) Assays HCC827 cells (ATCC, Cat CRL‐2868) were incubated with serial dilutions of EMB‐01 or a control antibody for 30 min at 37°C. Cells were

(9) IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non-small cell lung cancerMol CancerOctober 28, 2025Ritsu Ibusuki, Eiji Iwama, Atsushi Shimauchi, Hiromu Kawano, Shun Mizusaki, Satoshi Nakamura, Yui Miyazaki, Yu Inutsuka, Mikiko Hashisako, Taishi Harada, et al.reagents Five human NSCLC cell lines with EGFR activating mutations (PC-9 [ECACC #90071810], HCC827 [ATCC #CRL-2868], H1975 [ATCC #CRL-5908], H1650 [ATCC #CRL-5883], and HCC4006 [ATCC #CRL-2871]) and five human NSCLC

(10) Propionate metabolism dysregulation promotes drug-tolerant persister cell survival in non-small cell lung cancerbioRxivOctober 18, 2025Bobak Parang, Liron Yoffe, Rabia Khan, Zhongchi Li, Michal J. Nagiec, Eric E. Gardner, Yiwey Shieh, Rachel S. Heise, Ashish Saxena, Nasser Altorki, et al.signed-rank test. Cell Culture The H1975 and HCC827 cells were purchased from ATCC (CRL-5908 and CRL-2868). The PC9 cells were a gift from the laboratory of Dr. Harold Varmus. Cells were maintained in RPMI

(11) Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposuresCancer CellSeptember 8, 2025Shankha Satpathy, Natalie M. Clark, Yi-Ju Chen, Noshad Hosseini, Ya-Hsuan Chang, Yi Hsiao, Jonathan T. Lei, Francesca Petralia, Jin-Shing Chen, Yifat Geffen, et al.(ATCC),Catalog: HTB-111 T47D,ATCC,Catalog: HTB-111 KPL1,DSMZ,Catalog: ACC-317 H3122,ATCC,Catalog: CRL-2868 H2228,ATCC,Catalog: CRL-5935 LS513,ATCC,Catalog: CRL-2134 H747,ATCC,Catalog: CCL-252 NCI-H1975,ATCC,Catalog:

(12) Current and Emerging Therapies for Targeting the ERK1/2 & PI3K Pathways in CancerInternational Journal of Molecular SciencesSeptember 6, 2025Ethan Abizadeh, Eli Berglas, Aaron Abizadeh, Julia Glatman, Aaron B. Lavi, Mark Spivak, Tzuriel Sapir, David ShiftehEGFR/PI3K/AKT pathway, thereby reversing Gefitinib resistance in NSCLC cells such as HCC827 (ATCC catalog #CRL-2868, harboring an exon 19 deletion in EGFR) and PC-9 (MilliporeSigma catalog #90071810-1VL, harboring an

(13) A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug ResistanceResearchSquareAugust 5, 2025Prashath Karunaraj, Prashath Karunaraj, Malcolm L. Scheele, Malcolm Rathod, Ipek Simay Rathod, Sophia Abrahamson, Sophia Abrahamson, Lamia Chowdhury, Lamia Chowdhury, Weixiao Kazmi, et al.RRID:CVCL_0063), U-2 OS (ATCC - HTB-96™, RRID:CVCL_0042), BT20 (ATCC - HTB-19™, RRID:CVCL_0178), HCC827 (ATCC - CRL 2868, RRID:CVCL_2063), SYF KO (ATCC - CRL-2459, RRID:CVCL_6461), and SV40 immortalized Mouse embryonic fibroblast

(14) EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLCCell reports. MedicineJuly 15, 2025Zhou Z, Chen S, Zhao J, Du X, Yin H, Zhou C, Hu H, Yu Y, Zhu Y, Yao H.lines,Experimental models: Cell lines,Experimental models: Cell lines ,, PC9,Pricella,CL-0668 HCC827,ATCC,CRL-2868 A549,ATCC,CRM-CCL-185 ,, Experimental models: Organisms/strains,Experimental models: Organisms/strains,Experimental models

(15) A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug ResistancebioRxivJune 19, 2025Prashath Karunaraj, Remkes Scheele, Malcolm L. Wells, Ruchita Rathod, Sophia Abrahamson, Lila C. Taylor, Ipek S. Gokulu, Lamia Chowdhury, Abiha Kazmi, Weixiao Song, et al.RRID:CVCL_0063), U-2 OS (ATCC - HTB-96™, RRID:CVCL_0042), BT20 (ATCC - HTB-19™, RRID:CVCL_0178), HCC827 (ATCC - CRL 2868, RRID:CVCL_2063), SYF KO (ATCC - CRL-2459, RRID:CVCL_6461), and SV40 immortalized Mouse embryonic fibroblast

(16) Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylationCell Chemical BiologyJune 19, 2025Marta Baro, Hojin Lee, Vanessa Kelley, Rongliang Lou, Chatchai Phoomak, Katerina Politi, Caroline J. Zeiss, Michael Van Zandt, Joseph N. Contessalines H3255,ATCC,CRL-2882 HCC-4006,ATCC,CRL-2871 HCC-2935,ATCC,CRL-2869 H1975,ATCC,CRL-5908 HCC827,ATCC,CRL-2868 PC9,Gift from Dr. K. Politi (Yale Univ),N/A HEK293-WT,"Described in Rinis et al., 201828",N/A HEK293-STT3A

(17) Neuregulin 4: A Key Regulator in Suppressing Lung Adenocarcinoma ProgressionTechnology in Cancer Research & TreatmentMay 23, 2025Shufan Zhang, Tianhan Xu, Simeng Li, Liming Tang, Dongmei WangReagents Human lung adenocarcinoma cell lines A549 (ATCC:CCL-185; RRID:CVCL_0023) and HCC827 (ATCC:CRL-2868; RRID:CVCL_2063) were cultured in 1640 and mouse lung adenocarcinoma cell LLC (ATCC:CRL-1642; RRID:CVCL_5653)

(18) Deciphering the history of ERK activity from fixed-cell immunofluorescence measurementsNat CommunMay 21, 2025Abhineet Ram, Michael Pargett, Yongin Choi, Devan Murphy, Carolyn Teragawa, Markhus Cabel, Nont Kosaisawe, Gerald Quon, John G. Albeck20 ng/ml EGF, 10 μg/ml Insulin, 500 ng/ml hydrocortisone, and 100 ng/ml cholera toxin. HCC827 (ATCC, CRL-2868) and A549 (ATCC, CCL-185) cells were maintained in RPMI supplemented with 10% Fetal Bovine Serum (FBS)

(19) A novel mesenchymal epithelial transition (MET) inhibitor, CB538, relieves acquired resistance in EGFR-mutated MET-amplified non-small cell lung cancerTranslational Cancer ResearchMarch 30, 2025Ji Yeon Song, Hyunsook An, Soojeong Kimgifted from Dr. Byoung Chul Cho lab (Yonsei Univ College of Medicine, Seoul, Korea), and HCC827 cell (#CRL-2868) was obtained from ATCC (Rockville, MD, USA). EGFR-TKI-resistant cells, erlotinib-resistant PC-9/ER,

(20) Modulation of tumor inflammatory signaling and drug sensitivity by CMTM4The EMBO journalMarch 1, 2025Xu Y, Kang K, Coakley BA, Eisenstein S, Parveen A, Mai S, Wang YS, Zheng J, Boral D, Mai J, et al.CRL-2539 HEK-293 cells,ATCC,CRL-1573 B16-F10 cells,ATCC,CRL-6475 LLC cells,ATCC,CRL-1642 HCC827 cells,ATCC,CRL-2868 H292 cells,ATCC,CRL-1848 Recombinant DNA,Recombinant DNA,Recombinant DNA pSIREN-RetroQ,Clontech Laboratories

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HCC827 from ATCC

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