NCI-H460 [H460] from ATCC

Product Specs
ItemNCI-H460 [H460]
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberHTB-177
TypeCell Biology
SpeciesHomo sapiens
TissueLung, Pleural effusion
DiseaseCarcinoma
Cell LineNCI-H460
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Lung

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Imidazole-2-thione derivatives as new selective anticancer agents with anti-metastatic properties: synthesis and pharmacological evaluationJournal of Enzyme Inhibition and Medicinal ChemistryDecember 31, 2026Božena Golcienė, Natalia Maciejewska, Anoop Kallingal, Birutė Sapijanskaitė-Banevič, Maryna Stasevych, Vytautas MickevičiusNCI-H-226 (lung squamous cell carcinoma, ATCC® CRL-5826™), NCI-H-460 (large cell lung carcinoma, ATCC® HTB-177™), HCT116 (colorectal carcinoma, ATCC® CCL-247™), Hep G2 (hepatocellular carcinoma, ATCC® HB-8065™),

(2) Damage to newly synthesized proteins is a major cause of Cd(II) toxicity counteracted by proteasomes and integrated stress response in human cellsChemico-Biological InteractionsJune 1, 2026Giorgiana Madalina Ursu, Anatoly Zhitkovichhuman cells. 2. Materials and methods 2.1. Cell culture Human lung epithelial cells (H460, cat. # HTB-177), immortalized human kidney cells (293T, cat. # CRL-3216) and primary renal proximal tubule epithelial cells

(3) Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulationLife Science AllianceMay 1, 2026Noemi Garcia Garcia, Thanh Ha Vy Nguyen, Dane Richey, Emily F Cox, Jon Coca Juaristi, Cody Ashby, Analiz Rodriguez, Katie R Ryanpatients with high Rnd3 versus low Rnd3 groupings. Cell culture Authenticated A549 (CCL185) and H460 (HTB-177) lung adenocarcinoma cells and A375 (CRL1619) melanoma cells were obtained from the ATCC. For primary

(4) A covalent allosteric molecular glue suppresses NRF2-dependent cancer growthCancer DiscoveryMay 1, 2026Nilotpal Roy, Tine Wyseure, I-Chung Lo, Justine Lu, Christie L. Eissler, Steffen M. Bernard, Ilah Bok, Aaron N. Snead, Albert Parker, U-Ging Lo, et al.(ATCC; cat. #CRL-2610);NCI-H2122 (ATCC; cat. #CRL-5985);A549 (ATCC; cat. #CCL-185);NCI-H460 (ATCC; cat. #HTB-177);NCI-H2023 (ATCC; cat. #CRL-5912);BICR16 (Sigma-Aldrich; cat. #06031001);PC9 (Sigma-Aldrich; cat. #90071810);

(5) IL-7Rα signaling potentiates the anti-tumor activity of NK92 cellsFrontiers in ImmunologyMarch 30, 2026Chunli Wang, Seokmin Kim, Ling-Zu Kong, Inhwan Jang, Seona Jo, Sunyoung Lee, Soo Yun Lee, Kee K. Kim, Tae-Don Kim(Human breast cancer cell line, ATCC®CRM-HTB-26™), NCI-H460 (human non-small cell lung cancer, ATCC®HTB-177™), MOLT 4 (human T lymphoblast cell line, ATCC®CRL-1582™), K562 (human leukemia cell line, ATCC®CCL-243™),

(6) Riboflavin metabolism shapes FSP1-driven ferroptosis resistanceNature Cell BiologyMarch 13, 2026Vera Skafar, Izadora de Souza, Biplab Ghosh, Ancely Ferreira dos Santos, Florencio Porto Freitas, Zhiyi Chen, Shibo Sun, Merce Donate Castillo, Palina Nepachalovich, Lars Seufert, et al.and H460 were purchased from ATCC (cat. nos. CCL-121, CRL-1619, CRM-HTB-26, HTB-130, CRM-CCL-185 and HTB-177, respectively) and PC-9 cells were purchased from Sigma (cat. no. 90071810). Cells were cultured in

(7) Macropinocytosis and Vascularization Determine Response to mTOR Inhibitors in Lung Squamous Cell CarcinomaCancer ResMarch 2, 2026Morgan R Brady, Nedas Matulionis, Heather R Christofk, Edward B Garon, Aaron Lisberg, David B Shackelford, Milica MomcilovicDepMap ID: ACH-000395; LUSC; ATM P383A, TP53 W146Stop, CDKN2A G45VfsStop; RRID:CVCL_1566), H460 (ATCC: HTB-177, DepMap ID: ACH-000463; Large Cell Lung Carcinoma (LCLC); KRAS Q61H, PI3KCA E454K, STK11 Q37Stop, KEAP1

(8) Comprehensive Profiling of N 6 ‐methyladnosine (m 6 A) Readouts Reveals Novel m 6 A Readers That Regulate Human Embryonic Stem Cell DifferentiationAdvanced ScienceMarch 1, 2026Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, et al.CVCL_0023), JURKAT cell line (ATCC, catalog#TIB‐152, RRID: CVCL_0367) and H460 cell line (ATCC, catalog#HTB‐177, RRID: RRID: CVCL_0459) were obtained from the American Type Culture Collection (Manassas, VA, USA)

(9) Lung cancer-enriched p53 mutants occupy canonical p53 target genes without activating transcription, revealing a distinct loss-of-function behaviorbioRxivFebruary 20, 2026Mason A. Tracewell, Hailey N. Shankle, Samantha M. Barnada, Khushali S. Vyas, Kevin M. Kim, Theodhora Qyshkollari, Jonathan E. Karlin, Julie A. Barta, Steven B. McMahontherapeutic approach in human cancer. Materials and Methods: Cell Culture Human NCI-H460 (ATCC HTB-177), NCI-H1299 (ATCC CRL-5083), and NCI-H2087 (ATCC CRL-5922) cells were purchased from the American Type

(10) Tumor-intrinsic PD-L1 drives lung cancer progression in response to TLR stimulation by promoting autophagy through the TRAF6–BECN1 signaling axisExperimental Hematology & OncologyFebruary 16, 2026Yoolim Sung, Ha-Jeong Lee, Mi-Jeong Kim, Ji Hye Shin, Ji Young Kim, Yeeun Kang, Chaeeun Lee, Duk-Hwan Kim, Jae-Hyuck Shim, Tae Jin Kim, et al.Sungkyunkwan University. Cells Human lung adenocarcinoma A549 (CCL-185) and large-cell carcinoma H460 (HTB-177) cell lines, as well as human embryonic kidney HEK293T (CRL-11268) cells, were obtained from ATCC. A549

(11) Basroparib inhibits YAP ‐driven cancers by stabilizing angiomotinMolecular OncologyJanuary 22, 2026Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung KimCVCL_0428), A549 (ATCC CCL‐185, RRID: CVCL_0023), MCF‐7 (ATCC HTB‐22, RRID: CVCL_0031), and H460 (ATCC HTB‐177, RRID: CVCL_0459). COLO320DM, DLD‐1, SW480, SW620, HCT116, H1299, BT‐549, H358, A549, and H460 cells

(12) Anticancer Activity of 2,3′-Dihydroxy-5′-Methoxystilbene Against NSCLC Cell Lines Through AKT-Dependent Mechanisms: A Comprehensive In Vitro and Computational AnalysisInternational Journal of Molecular SciencesJanuary 10, 2026Phisit Pouyfung, Nonthalert Lertnitikul, Noriyoshi Ogino, Achitphol Chookaew, Varisa Pongrakhananon, Piriya Chonsut, Natthaporn Sueangoen, Suwichak Chaisit2,3′-dihydroxy-5′-methoxystilbene-treated group. 4.2. Cell Culture Human non-small-cell lung cancer cell lines H460 (HTB-177), H23 (CRL-5800), and A549 (CCL-185), and the normal mouse embryonic fibroblast cell line NIH/3T3 (CRL-1658)

(13) Adamantyl-Substituted Chalcone CA13 Induces Cytoprotective Autophagy and JNK-Dependent Apoptosis in Lung Cancer CellsBiomoleculesDecember 30, 2025Yuting Chen, Yaxin Liu, Jing Zhou, Tingting Bao, Jing Wang, Mingtao Ao461.20, found 461.20. 2.2. Cell Culture Human lung cancer cell lines A549 (ATCC® CCL-185), H460 (ATCC® HTB-177), H292 (ATCC® CRL-1481), and the normal lung fibroblast line MRC-5 (ATCC® CCL-171) were obtained from

(14) A Covalent Allosteric Molecular Glue Suppresses NRF2-Dependent Cancer GrowthCancer DiscovDecember 19, 2025Nilotpal Roy, Tine Wyseure, I-Chung Lo, Justine Lu, Christie L. Eissler, Steffen M. Bernard, Ilah Bok, Aaron N. Snead, Albert Parker, U-Ging Lo, et al.(ATCC; cat. #CRL-2610);NCI-H2122 (ATCC; cat. #CRL-5985);A549 (ATCC; cat. #CCL-185);NCI-H460 (ATCC; cat. #HTB-177);NCI-H2023 (ATCC; cat. #CRL-5912);BICR16 (Sigma-Aldrich; cat. #06031001);PC9 (Sigma-Aldrich; cat. #90071810);

(15) Iron-oxide nanoparticles selectively enhance the toxicity of pharmacological ascorbate through hydrogen peroxide-dependent DNA damage in non-small cell lung cancer (NSCLC)Free Radical Biology and MedicineDecember 16, 2025Mekhla Singhania, Sei Sho, Melissa A. Fath, Adriana Sanchez, Casey F. Pulliam, Bryan G. Allen, Garry R. Buettner, Prabhat C. Goswami, Maria Spies, Michael S. Petronek, et al.lymph node) and A549 (source: male, lung adenocarcinoma) were obtained from ATCC (CRL-5803, CCL-185 and HTB-177 respectively). To produce a more aggressively growing variant of H1299 for xenograft model systems,

(16) Macropinocytosis and Vascularization Determine Response to mTOR Inhibitors in Lung Squamous Cell CarcinomaCancer ResearchDecember 9, 2025Morgan R. Brady, Nedas Matulionis, Heather R. Christofk, Edward B. Garon, Aaron Lisberg, David B. Shackelford, Milica MomcilovicDepMap ID: ACH-000395; LUSC; ATM P383A, TP53 W146Stop, CDKN2A G45VfsStop; RRID:CVCL_1566), H460 (ATCC: HTB-177, DepMap ID: ACH-000463; Large Cell Lung Carcinoma (LCLC); KRAS Q61H, PI3KCA E454K, STK11 Q37Stop, KEAP1

(17) QSAR machine learning-guided discovery of renieramycin right-half derivatives with cytotoxic activity against NSCLC cellsSci RepDecember 5, 2025Ismail Dwi Putra, Phornphimon Maitarad, Masashi Yokoya, Zin Zin Ei, Daiki Hotta, Liyi Shi, Thanyada Rungrotmongkol, Pithi Chanvorachotefor the compound set were obtained from multiple studies that employed the same cell line (H460, ATCC HTB-177) and method (MTT cytotoxic assay). Cytotoxicity values were scaled to molar concentrations (M) and transformed

(18) Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1 -Mutant Lung CancerCancer ResearchDecember 1, 2025Melat T. Gebru, Timothy E. Hoffman, Aaron Boudreau, Ngoc Vu, Fei Han, Putianqi Wang, Eddie Folk, Xiumin Wu, James Newton, Kelly D. Foster-Duke, et al.Cell culture and cell line generation The KEAP1-mutant cell lines A549 (CCL-185, RRID: CVCL_0023), H460 (HTB-177, RRID: CVCL_0459), H2122 (CRL-5985, RRID: CVCL_1531), H2023 (CRL-5912, RRID: CVCL_1515), H1944 (CRL-5907,

(19) Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycleMolecular CellNovember 20, 2025Mushtaq A. Nengroo, Austin T. Klein, Heather S. Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel J. McGrail, Nidhi Sahni, Niklas B. Thompson, Peter A. Faull, Peng Gao, et al.Lines HEK293E,John Blenis lab (Weill Cornell Medicine),N/A HeLa,ATCC,CCL-2 CAL-51,DSMZ,ACC 302 H460,ATCC,HTB-177 CT-26,ATCC,CRL-2638 786-O,ATCC,CRL-1932 PC-3M,Cytion,305061 hTERT-RPE1,ATCC,CRL-4000 HEK293T,ATCC,CRL-3216 Mouse embryonic stem cells

(20) PYCR1 drives lung cancer progression through functional interactions with EGFR and TLR signaling pathwaysExperimental & Molecular MedicineNovember 18, 2025Ji Hye Shin, Ji Young Kim, Mi-Jeong Kim, Yeeun Kang, Ha-Jeong Lee, Bongkum Choi, Ji Su Lee, Dohee Kwon, Seo Hyun Kim, Yoolim Sung, et al.cells (human NSCLC cell line; CRL-5803, ATCC), H460 cells (human large-cell lung cancer cell line; HTB-177), H358 cells (human bronchioalveolar carcinoma cell line; CRL-5807), H1975 cells (human lung cancer

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NCI-H460 [H460] from ATCC

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