HK-2 from ATCC

Product Specs
ItemHK-2
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberCRL-2190
TypeCell Biology
SpeciesHomo sapiens
Tissuekidney, Cortex:Proximal tubule
Cell LineHK-2
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Kidney
Ageadult
DiseasePapilloma

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) RhoB supports rubella infection and impairs endothelial barrier integrity through downstream ROCK signalingCell Commun SignalApril 27, 2026Igor Kovacevic, Marie Müller, Leonie Mair, Vivien Henschke, Annkatrin Kowalski, Jes-Niels Boeckel, Karolin Kropf, Guido Posern, Uta Reibetanz, Claudia Clauspassaging was initiated at confluency with 0.1% trypsin–EDTA. Human kidney epithelial cells (HK-2), (CRL-2190, ATCC) were grown in Dulbecco’s modified eagle medium (DMEM) supplemented with 10% FCS and 1 mg/ml D-Glucose.

(2) Reappraisal of profibrotic phenotype and cell-cycle state of renal tubular epithelium after ischemia-reperfusion injuryPLoS OneApril 24, 2026Daichi Fukaya, Wakako Kosakai, Tetsuya Sato, Tsutomu Inoue, Hiroaki Amano, Takeru Kusano, Hirokazu Okada[14]. HK-2 cell line The cultured human renal tubular epithelial cell line HK-2 (ATCC Catalog Number: CRL-2190) was cultured in the Ham’s F-12 and Dulbecco’s Modified Eagle Medium (4.5 g/L glucose) (Nacalai Tesque,

(3) Chitosan nanoparticle encapsulated pentoxifylline improves renal protection and reduces oxidative stress in amikacin induced nephrotoxicityDiscov NanoApril 18, 2026Nada Moustafa, Mona B. Abd El-Latif, Alyaa Farid(human embryonic kidney cells, ATCC® CRL-3216™) and HK-2 (human proximal tubular epithelial cells, ATCC® CRL-2190™) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT; Sigma-Aldrich, USA) assay.

(4) Enhancement of tobramycin and amikacin activities by co-encapsulation in liposomal-thymoquinone formulation: antibacterial, antibiofilm, and cytocompatibility studyTher DelivApril 10, 2026Raghad R. Alzahrani, Manal M. Alkhulaifi, Abdulkareem M. Albekairy, Bahauddeen M. Alrfaei, Rizwan Ali, Salleh N. Ehaideb, Mohammed A. Assiri, Alaa Eldeen B. Yassin, Majed A. HalwaniKidney cell cytocompatibility with liposomal formulations Cell Culture Human kidney-derived HK-2 (ATCC CRL-2190) and HEK293T (ATCC CRL-3216) cell lines were obtained from the American Type Culture Collection (ATCC;

(5) Thioxanthone-Mediated Cytoprotection Against Cisplatin Toxicity: Exploring the Potential Involvement of P-Glycoprotein Through Computational and Experimental ApproachesJ XenobiotMarch 21, 2026Jéssica Veiga-Matos, Daniel J V A Dos dos Santos, Andreia Palmeira, Emília Sousa, Ana I. Morales, Marta Prieto, Fernando Remião, Renata Silvathe risk of solvent-related cytotoxic effects. 2.2.2. Cell Culture Human kidney (HK)-2 cells (ATCC® CRL-2190), obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA), were routinely cultured

(6) Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High‐Sodium Diet With Renal Proinflammatory PathwaysJournal of the American Heart AssociationMarch 17, 2026Fabrizio Buffolo, Jacopo Burrello, Barbara Pardini, Sonia Tarallo, Elisabetta Casalone, Giovanni Birolo, Margherita Alba Carlotta Pomatto, Brooke Honzel, Laura Tsai, Paolo Mulatero, et al.for each condition and respective mRNA targets. In Vitro Experiments Human kidney 2 cells (ATCC, CRL‐2190–passage 7–10) were transfected with mirVana miRNA inhibitors for hsa‐miR‐320b and hsa‐miR‐10b‐5p (Applied Biosystems

(7) The hippo-YAP1/TEAD1-SLC7A5 axis: uncovering a novel therapeutic target for oxalate-induced renal tubular ferroptosisRedox RepMarch 16, 2026Junyi Yang, Zhilong Ma, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Guoruiyu Lyu, Yang Xun, Xiao Yuand human embryonic kidney cells (HEK-293 T) were obtained from the American Type Culture Collection (CRL-2190, CRL-11268, ATCC, USA) and cultured under standard conditions (37°C, 5% CO₂, humidified air). Cells

(8) Heterogeneity in lysosomal dynamics and metabolic functions along the kidney proximal tubuleNature CommunicationsMarch 9, 2026Monika Kaminska, Imene B. Sakhi, Nevena Jankovic, Marcello Polesel, Andrew M. Hallexperiments were conducted at 37 °C, 5% CO2. Imaging of late endosomes and lysosomes in cells HK-2 cells (CRL-2190, ATCC) were transfected with 1.5 µg of mScarlet-Rab7 plasmid (Addgene, #169068) using Lipofectamine 3000

(9) Involvement of c-Myc/WWP1/TRIM65 Axis in Renal FibrosisBiomoleculesMarch 2, 2026Sonia Mazumder, Cody Gifford, Jiaqi Tang, Fortis Gaba, Varsha Mondal, Roel Goldschmeding, Rohan Samarakoon, Paul J. HigginsGeneration of Stable Single and Double Transductants Human renal proximal tubular epithelial cells (HK-2) (CRL-2190- ATCC, Manassas, VA, USA) were grown in DMEM media M (1X) + GlutaMAX-I (10567-014, Gibco, Thermo Fisher

(10) Pyrimidinergic calcium signaling links tubular metabolism to fibrosis in kidney diseaseNature CommunicationsFebruary 19, 2026Andreja Figurek, Nevena Jankovic, Sarah Kollar, Monika Kaminska, Imene Sakhi, Anna Rinaldi, Pietro E. Cippà, Bernard Robaye, Andrew M. Hall5% fetal bovine serum and 1% penicillin/streptomycin. Human cortical proximal tubular cells (HK-2, CRL-2190, ATCC) were cultured in DMEM/F12 media supplemented with REGM Renal Epithelial Cell Growth Medium BulletKit

(11) Nanoparticle-delivered miR-486-5p inhibits H 2 O 2 -induced injury in cultured endothelial and kidney tubular epithelial cellsNanoscale AdvancesFebruary 17, 2026Ali O. Maadelat, Savindi Wehella, Adrianna Douvris, Shireesha Manturthi, Kevin D. Burns, Suresh GaddeType Culture Collection (ATCC; Boston, MA USA): HUVECs (PCS-100-013), hPTECs (PCS-400-010), HK2 cells (CRL-2190), renal epithelial cell basal medium (PCS-400-030), renal epithelial cell growth kit (PCS-400-040),

(12) Biochanin A, a Plant Isoflavone, Disrupts Peptidoglycan Biosynthesis by Downregulating femA and femB, and Impairs Cell Wall Integrity in Multidrug-Resistant Staphylococcus aureusAntibiotics (Basel)February 10, 2026Jade Joshua R. Teodosio, Kathryn Ann H. Dizon, Julyanna R. Bruna, Jan Vincent N. Sollesta, Zenith M. Villorente, Jonel P. Saludes, Doralyn S. DalisayToxicity Assay To establish the safety of Biochanin A in normal and model cell lines, we utilized kidney HK-2 (ATCC CRL-2190), liver HepG2 (ECACC 85011430), and cardiac H9c2 (ECACC 88092904). Results revealed that MIC80 concentration

(13) Opposite Effects of Diacylglycerol and Phosphatidic Acid in the Modulation of the Plasma Membrane Ca2+-ATPase from Kidney Proximal Tubules: A Regulatory Role for Diacylglycerol Kinase in Calcium Homeostasis?BiomedicinesFebruary 8, 2026Gloria M. R. S. Grelle, Pilar A. M. Moreno, Thais A. Bonilha, Osman F. Silva, Rafael Garrett, Fábio Ricardo M. Botelho, Luciana Nogaroli, Rafael H. F. Valverde, Marcelo Einicker-Lamasand averaged. 2.3. Cell Cultures Human renal proximal tubule cells (HK-2, ATCC, Manassas, VA, USA: CRL:2190) were cultured in Keratinocyte Serum Free Medium (KSF-M, Thermo Fisher Scientific, Waltham, MA, USA)

(14) Progranulin impairs efferocytosis of macrophages in renal fibrosis by negatively regulating PPAR-δ-mediated inhibition of the JAK-STAT signaling pathwayCell Mol Life SciFebruary 7, 2026Yang Zhao, Weichao Tu, Yang Liu, Xiaoqian Yang, Yueyan Li, Hao Yananalyses as described. Cell culture and grouping Human proximal tubular epithelial cells (HK-2, ATCC® CRL-2190™) were cultured in Dulbecco’s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12; Gibco, USA) supplemented

(15) NMN protects cisplatin-associated AKI via NAD+/SIRT1 pathwayFrontiers in ImmunologyFebruary 4, 2026Zhaozhi Wen, Jiazeng Wang, Yihang Yang, Longlong Chen, Xiangge Ji, Dong Liu, Chongxu ShiGuide for the Care and Use of Laboratory Animals. In vitro study HK-2 cells (human kidney-2; ATCC CRL-2190) were obtained from Bluefbio Co. (China) and cultured in Dulbecco’s Modified Eagle Medium (DMEM; Pricella,

(16) Stimulator of Interferon Genes Is a Fine-Tuner, but Not a Prime Mover, of Kidney InflammationThe American Journal of PathologyFebruary 1, 2026Madiha Zahra Syeda, Emily S.H. Yeung, Lisa Y.Q. Hong, Suzanne L. Advani, Youan Liu, Laurette Geldenhuys, Ferhan S. Siddiqi, Veera Ganesh Yerra, Sri Nagarjun Batchu, Andrew AdvaniDye Reagent (5000205; Bio-Rad, Hercules, CA). Cell Culture HK-2 cells were from ATCC (Manassas, VA; CRL-2190), human glomerular endothelial cells were from Sciencell Research Laboratories (Carlsbad, CA), and conditionally

(17) Transcriptional response to combination antiretroviral therapy predicts side effects and novel targetsFrontiers in PharmacologyJanuary 21, 2026Alexander Lachmann, Letizia Amadori, Paola Nicoletti, Heidi M. Crane, Chiara Giannarelli, Avi Ma’ayan, Inga Peteral., 1982; Ibanez et al., 2012; Talukdar et al., 2016). HK-2 cells (5,000 cells/well; ATCC, cat. no. CRL-2190) were cultured in Keratinocyte Serum Free Medium (K-SFM), Kit (Gibco, cat. no. 17005-042) at 37 °C,

(18) Anticancer Potential of Cannabidiol in Renal Cell Carcinoma: Serum Modulation and Preliminary Mechanistic InsightsJournal of Clinical MedicineJanuary 19, 2026Débora Sousa, Filipa Amaro, Ana Margarida Araújo, Márcia Carvalho769-P (ATCC® CRL-1933), along with the non-tumoral proximal tubular epithelial cell line HK-2 (ATCC® CRL-2190), were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). Cells were routinely

(19) Nanoplastic toxicity and uptake in kidney cells: differential effects of concentration, particle size, and polymer typeCell Biology and ToxicologyJanuary 16, 2026Hayden Louis Gillings, Darling M. Rojas-Canales, Soon Wei Wong, Kaustubh R. Bhuskute, Amandeep Kaur, Iliana Delcheva, Jonathan M. Gleadle, Melanie MacGregormeasurements. Each sample was measured in triplicate. Cell culture and nanoplastics exposure HK-2 cells (ATCC CRL-2190) were cultured in 1:1 Dulbecco’s Modified Eagle Medium (DMEM) and Ham’s F-12 (Gibco), and supplemented

(20) Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancerCommunications MedicineJanuary 12, 2026Jennifer A. Heritz, Sarah J. Backe, Angela Pacherille, Sara J. Cayaban, Michael F. Basin, Britannia Smith, Rebecca A. Sager, Michael Daneshvar, Dawn E. Post, Mark R. Woodford, et al.embryonic kidney (HEK293) (ATCC, Cat# CRL-1573; RRID:CVCL_0045), (Human, unknown) and HK-2 (ATCC, Cat# CRL-2190; RRID:CVCL_0302), (Human, Male) cells were grown in Dulbecco’s Modified Eagle Medium (DMEM, Sigma-Aldrich),

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HK-2 from ATCC

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