SCC-25 from ATCC

Product Specs
ItemSCC-25
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberCRL-1628
TypeCell Biology
SpeciesHomo sapiens
TissueTongue
Cell LineSCC-25
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Tongue
Age70 years
DiseaseSquamous Cell Carcinoma

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Benzyl-Naphthoquinones as Selective Anticancer Agents for Oral Squamous Cell Carcinoma via Apoptosis InductionBiomedicinesMarch 26, 2026Antonio Mendonça Marconi-Nicolau, Rebeca Gripp de Sá, Caroline Reis Santiago Paschoal, Lethícia Andrade de Almeida, Gabriel Ouverney, Ana Caroline dos Santos-Diniz, Anamel Blaudt Meira, João Pedro da Costa Faria Brunhosa, Luiz Carlos da Silva Pinheiro, Paula Alvarez Abreu, et al.from the American Type Culture Collection (ATCC, Manassas, VA, USA) (ATCC numbers: CRL-1624, CRL-1629, CRL-1628, HB-8065, HTB-38, CCL-247, CCL-2, CRL-6475, CRL-2539, respectively). Primary normal human gingival fibroblasts

(2) Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populationsCell ReportsFebruary 24, 2026Xiaowen Hu, Jie Huang, Jiao Yuan, Yanrong Sun, Yuxin Wang, Zhongyi Hu, Junjie Jiang, Zhiling Wang, Bingwei Wang, Meixiao Long, et al.Program,RRID:CVCL_1629 PEO1,Sigma Aldrich,Cat# 10032308 SCC-9,ATCC,Cat# CRL-1629 SCC-15,ATCC,Cat# CRL-1623 SCC-25,ATCC,Cat# CRL-1628 SK-BR-3,ATCC,Cat# HTB-30 SK-CO-1,ATCC,Cat# HTB-39 SW 620,ATCC,Cat# CCL-227 U-87 MG,ATCC,Cat# HTB-14 UPCI-SCC-040,DSMZ,Cat#

(3) ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1Cellular and Molecular Life SciencesFebruary 21, 2026Uyanahewa Gamage Shashini Janesha, Chang-Ta Chiu, Ming-Hsien Tsai, Keng-Ming Chang, Chih-Yen Chien, Hui-Shan Huang, Hao-Yi Li, Yao-Chung Yang, Hui Lu, Cheng-Tang Pan, et al.HPV-negative, CCL-138™, ATCC), FaDu (hypopharyngeal, HPV-negative, HTB-43™, ATCC), and SCC-25 (tongue, CRL-1628™, Food Industry Research and Development Institute, Hsinchu, Taiwan). All cell lines were cultured under

(4) Pharmacological inhibition of frizzled 4 delays cell cycle progression and limits oral squamous cell carcinoma growthFrontiers in Cell and Developmental BiologyFebruary 17, 2026Riccardo Destefani, Ilaria J. Valookkaran, Sabrina Bensland, Christian T. Meisel, Cristina PorcheriSCC25 cells derived from the tongue of a 70-year-old male patient with squamous cell carcinoma (ATCC #CRL-1628) (Rheinwald and Beckett, 1981). Immunofluorescence confirmed FZD4 expression, displaying a membrane-associated,

(5) Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface targetCell Reports MedicineFebruary 17, 2026Meinusha Govindarajan, Salvador Mejia-Guerrero, Shawn C. Chafe, Shahbaz Khan, Wei Shi, Matthew Waas, Martin A. Rossotti, Amanda Khoo, Lydia Y. Liu, Vladimir Ignatchenko, et al.Tsao,RRID:CVCL_W786 SCC4,ATCC,Cat# CRL-1624; RRID:CVCL_1684 SCC8,Dr. R. Grénman,N/A SCC25,ATCC,Cat# CRL-1628; RRID:CVCL_1682 SCC42a,Dr. R. Grénman,RRID:CVCL_7847 Patient-derived lung-to-brain cancer cells (BT530),Dr.

(6) Effect of the G-Protein-Coupled Receptor T2R14 on Proliferation and Cell Population Growth in Oral Cancer CellsCellsFebruary 1, 2026Yongqiang Chen, Manikanta Kella, Kayla Austin, Rajinder P. Bhullar, Prashen ChelikaniSan Francisco-Oral Tongue-1109) (CRL-3442), CAL27 (CRL-2095) (tongue epithelial cells), and SCC-25 (CRL-1628) (tongue epithelial cells), were purchased from ATCC (American Type Culture Collection, Manassas, USA).

(7) Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinomaNature CancerJanuary 2, 2026Natalie L. Silver, Jin Dai, Travis D. Kerr, Jessica Altemus, Rekha Garg, Hannah Simmons, Tyler Alban, Laura Noel-Romas, Vladimir Makarov, David J. H. Shih, et al.supplemented with 10% FBS (Gibco). OQ01 (provided by L.-J. Chang, University of Florida) and SCC-25 (ATCC, CRL-1628) cells were cultured in DMEM/F12 (Media Core) supplemented with 10% FBS (Gibco). PCI-15B (provided by

(8) The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis PathwaysJournal of Oral Pathology & MedicineJanuary 1, 2026Leong‐Perng Chan, Ya‐Ping Tseng, Hui‐Ching Wang, Chen‐Yu Chien, Che‐Wei Wu, Ling‐Feng Wang, Tung‐Wen Yen, Po‐Chun Wang, Chih‐Chuang Liaw, Chia‐Hua Liangsquamous cell carcinoma (SCC) SCC25 cells were obtained from the American Type Culture Collection (ATCC, CRL‐1628, RRID: CVCL_1682). Additionally, human oral cavity SCC cells (OCCM‐1, RRID: CVCL_6782) and human dysplastic

(9) Evaluation of Pafolacianine (Cytalux®) for Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma: A Negative Study with Important Clinical ImplicationsMolecular Imaging and BiologyDecember 11, 2025Lucas Mani, Syeda Maria Ahmad Zaidi, Estelle Martin, Carleigh Rose Burns, Abdullah Bin Naveed, Ashtyn McAdoo, Hidenori Tanaka, Eben Rosenthal, Marisa HomSigma #SCC075), UMSCC47 (lateral tongue origin, Millipore Sigma #SCC071), SCC25 (tongue origin, ATCC #CRL-1628), and SCC9 (tongue origin, ATCC #CRL-1629). Control cell lines included A549 (lung adenocarcinoma, ATCC

(10) Coumarin-1,2,3-Triazole Conjugates as Molecular Scaffolds for the Selective Induction of ROS-Driven Apoptosis in Cancer Cells in the Development of Pyruvate Kinase M2 InhibitorsACS OmegaDecember 9, 2025Gabriel Ouverney, Amanda de Andrade Borges, Acácio Souza da Silva, Caroline Reis Santiago Paschoal, Paula Alvarez Abreu, Analice Gonçalves Rodrigues da Cruz, Mateus de Freitas Brito, Lucas Silva Abreu, Vitor Francisco Ferreira, Fernando de Carvalho da Silva, et al.B16–F10) were obtained from the American Type Culture Collection (ATCC) (ATCC numbers: CRL-1624, CRL-1629, CRL-1628, HB-8065, CCL-247, CRL-2539, and CRL-6475, respectively). Primary normal human gingival fibroblasts

(11) The potential role of genus Treponema in carcinogenesis with a focus on oral squamous cell carcinoma: a scoping review of the evidenceBMC Oral HealthNovember 26, 2025Pratibha Gopalkrishna, Krishnananda Prabhu, Lakshmi Puzhankara, Madhurya Kedlaya, Somasish Ghosh Dastidar, Monica Charlotte Solomon, Thokur Sreepathy Muralidevelopment",Role in general carcinogenesis 4,"Peng et al. 2022, China [75]","OSCC cell line Cal-27 (ATCC CRL-1628)/Cell proliferation assay, tumourigenesis assay, Transmission electron microscopy, flow cytometry, sequencing,

(12) Cannabinoids shift the basal ganglia microRNA m6A methylation profile towards an anti-inflammatory phenotype in SIV-infected rhesus macaquesCommunications BiologyNovember 24, 2025Chioma M. Okeoma, Lakmini S. Premadasa, Chen S. Tan, Ionita C. Ghiran, Mahesh Mohanon STAT1 using the human squamous cell carcinoma (SCC-25) epithelial-like cell line (ATCC.org CAT# CRL-1628), as this cell line expressed high basal levels of STAT1 protein. SCC-25 cells were cultured in a 1:1

(13) Mechanistic Insights into the Anticancer Action of Novel 2-Hydroxy-1,4-naphthoquinone Thiol DerivativesACS OmegaSeptember 16, 2025Thaís Barreto Santos, Alex de Souza Cruz Lopes Canuto, João Francisco Blaudt Virgilio de Carvalho Meira, Ana Caroline Santos-Diniz, Rafaella Machado de Assis Cabral Ribeiro, Caroline Reis Santiago Paschoal, Vitor Won-Held Rabelo, Paula Alvarez Abreu, Vitor Francisco Ferreira, David Rodrigues da Rocha, et al.a human oral tongue SCC (squamous cell carcinoma), were obtained from ATCC (CRL-1624, CRL-1629, and CRL-1628, respectively) and maintained in 1:1 DMEM/F12 (Dulbecco’s modified Eagle’s medium and Ham’s F12 medium;

(14) LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosisOncogeneAugust 30, 2025Antonella Bacchiocchi, Michael Mak, Zerin Mahzabin Khan, Xiangyu Gong, Mario Sznol, Zhenkun Na, Haomiao Su, Lok Hei Chan, Qin Yan, Dejian Zhao, et al.(ATCC catalog number PTA-4488), U-87MG (ATCC catalog number HTB-14), and SCC25 (ATCC catalog number CRL-1628) (Supplementary Table S1). The melanoma cells were grown in OptiMEM medium (Invitrogen, Carlsbad, CA)

(15) EGFRvIII-driven microenvironmental fibroblast activation and transformation accelerate oral cancer progression via lipocalin-2/STAT3 axisNeoplasia (New York, N.Y.)August 1, 2025Peng HY, Chang KY, Chang WM, Wu CY, Lee HL, Chang YC, Liu KJ, Shiah SG, Kuo CC, Chang JY.CVCL_1684), SCC-9 (Cat# CRL-1629, RRID: CVCL_1685), SCC-15 (Cat# CRL-1623, RRID: CVCL_1681), and SCC-25 (Cat# CRL-1628, RRID: CVCL_1681) cells were cultured in DMEM/F12 (1:1) supplemented with 1 mM sodium pyruvate and 400

(16) Design and Synthesis of Boronic Chalcones with Dual Anticancer and Anti-Inflammatory ActivityMoleculesJuly 19, 2025Juliana Romano Lopes, Freddy Humberto Marin-Dett, Rita Alexandra Machado Silva, Rafael Consolin Chelucci, Lucília Saraiva, Maria Emília Sousa, Leonardo Luiz Gomes Ferreira, Adriano Defini Andricopulo, Paula Aboud Barbugli, Jean Leandro Dos Santostriplicate to ensure reproducibility. 4.4. Biological Evaluation 4.4.1. Cell Lines The SCC-25 (ATCC® CRL-1628™), Detroit-562 (ATCC® CCL-138™), and THP-1 (ATCC® TIB-202™) cells were purchased from Rio de Janeiro

(17) Oral Squamous Cell Carcinoma Exosomes Upregulate PIK3/AKT, PTEN, and NOTCH Signaling Pathways in Normal FibroblastsCurr Issues Mol BiolJuly 19, 2025Dijana Mitic, Milica Jaksic Karisik, Milos Lazarevic, Jelena Carkic, Emilia Zivkovic, Olivera Mitrovic Ajtic, Jelena MilasinCells were incubated at 5% CO2 at 37 °C. The oral cancer cell lines SCC–25 (ATCC®, Manassas, VA, USA, CRL-1628™) and SCC-15 (ATCC®, CRL-1623 ™) were cultured in DMEM/F12, supplemented with 10% FBS, 100 U/mL of a

(18) Influence of bismuth selenide nanoparticles on cell mitochondrial activity: implications for cancer therapySci RepJuly 1, 2025Agnieszka Nowak-Terpiłowska, Mahreen Akhtar, Gulzar Hussain, Adam Piasecki, Paulina Błaszkiewicz, Maciej Tuliński, Eryk Wolarz, Tomasz Karpiński, Marzena Liliana Wyganowskasuspension. Cell culture In this study, human gingival fibroblasts and human squamous carcinoma cells (SCC-25, CRL-1628™, ATCC) were used. Gingival fibroblasts were extracted from gingival tissue collected from five generally

(19) Microfibrillar-associated protein-2 facilitates aggressive progression of oral squamous cell carcinoma cells through Kelch-like E3 ubiquitin ligase-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling pathwayCytojournalJune 14, 2025Wanzhen Yang, Junyi Tu, Kaixi Dai, Kemin Jiaincluding squamous cell carcinoma (SCC)-4 (CRL-1624), SCC-9 (CRL-1629), SCC-15 (CRL-1623), SCC-25 (CRL-1628), and Cal27 (CRL-2095), were obtained from ATCC (Rockefeller, MD, USA). All cells were maintained at

(20) HPV status impacts oncobacteria abundance and prognostic relevance in head and neck squamous cell carcinomaOncogeneJune 10, 2025Travis D. Kerr, Natalie L. Silver, Radhika Duggal, Jin Dai, Hannah Simmons, Subha Singh, Akeesha A. Shah, Kristianna M. Fredenburg, Apollo R. Stacy, Daniel J. McGrailDr. Lung-Ji Chang), VU-147T (provided by Dr. Timothy Chan), SCC-9 (ATCC CRL-1629), and SCC-25 (ATCC CRL-1628) cells were culture in DMEM/F12 (CC Media Core) supplemented with 10% FBS (Hyclone). PCI-15B (provide

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SCC-25 from ATCC

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