DLD-1 from ATCC

Product Specs
ItemDLD-1
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberCCL-221
TypeCell Biology
SpeciesHomo sapiens
TissueLarge intestine, Colon
Cell LineDLD-1
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Colon
Cell Typeepithelial cell
Ageadult
DiseaseAdenocarcinoma Colorectal Dukes type C
ApplicationsThis cell line is a suitable transfection host

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Targeting ADAR1 p150 triggers tumor inhibition and antitumor immunity to overcome immunotherapy resistanceiScienceJune 19, 2026Zhichao(Eric) Ai, Yuying Bian, Gang Li, Xiaobin S. Wang, Sining Zhu, Yumeng Li, Xiangyu Yao, Zhipeng Yanpurchased from Shanghai Model Organism. Human tumor cell lines, including BJ (CRL-2522) and DLD-1 (CCL-221), were purchased from ATCC. Additional human cell lines used for global editing assessment included

(2) Hypoxia-responsive interaction between P-TEFb, BHLHE40, and Tim8-Tim13 regulates hypoxic gene transcriptionSci AdvMay 22, 2026Shimaa Hassan AbdelAziz Soliman, Simone De Fabritiis, Marta Iwanaszko, Lawrence Austin Lin, Madhurima Das, Sarah Gold, Grant David Andersen, Ram P. Chakrabarty, Navdeep S. Chandel, Ali Shilatifardfollowing cell lines were obtained from the American Type Culture Collection (ATCC): DLD-1 (catalog no. CCL-221), A549 (catalog no. CCL-185), HCT116 (catalog no. CCL-247), and HEK293T (catalog no. 3216). These cells

(3) The Contribution of Native Protein Complexes to Targeted Protein DegradationACS Chemical BiologyMay 15, 2026Lorraine Glennie, Nicole M. Curnutt, Gajanan Sathe, Brune Le Chatelier, Freya Goff, Jin-Feng Zhao, Tyrell Cartwright, Karen Dunbar, Nicola T. Wood, Thomas J. Macartney, et al.cell type,species,source wild-type DLD1,human,ATCC (CCL-221) wild-type U2OS,human,ATCC (HTB-96) wild-type A549,human,ATCC (CCL-185) wild-type TOV-21G,human,ATCC

(4) Exploring the role of hydrogen peroxide in the immune microenvironment of hypoxic tumorsClinical and Translational Radiation OncologyApril 25, 2026Febe Geirnaert, Lisa Kerkhove, Tim Everaert, Thierry Gevaert, Inès Dufait, Mark De RidderDLD-1 (human) colorectal cancer (CRC) cell lines (American Type Culture Collection (ATCC, CRL-2638 and CCL-221)) were cultured in Roswell Park Memorial Institute (RPMI, 21875–035, Thermo Fisher Scientific). Immunogenic

(5) Transcript-Specific DNA Methylation Alterations of the RASSF1 Locus in Cancer CellsGenes Chromosomes CancerApril 20, 2026Litzy Gisella Bermudez, Camila Bernal Forigua, Carmen María Ayala-Roldán, Jesús Manuel Romero, Rafael R. Ariza, Teresa Morales-Ruiz, Teresa Roldán-Arjona, Alejandra Cañas, Adriana RojasU373 (glioblastoma, also known as U‐373 MG, Sigma‐Aldrich 08061901); DLD‐1 (colorectal cancer, ATCC CCL‐221) and HCT116 (colorectal cancer, ATCC CCL‐247); MCF7 (breast cancer, ATCC HTB‐22) and HeLa (cervical cancer

(6) Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivobioRxivApril 11, 2026Tianzheng Ye, Azmain Alamgir, Cara M. Robertus, Darianna Colina, Connor Monticello, Thomas Connor Donahue, Lauren Hong, Sophia Vincoff, Shrey Goel, Peter Fekkes, et al.(BRC). Cell culture and transfection. The human CRC cell line, DLD1, was purchased from ATCC (cat # CCL-221). DLD1 cells were cultured in RPMI1640 media (ThermoFisher) supplemented with 100 units/mL penicillin,

(7) Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progressionCell Death & DiseaseApril 10, 2026Lili Li, Taekyu Ha, Jing-Xin Feng, Michael DiPrima, Dunrui Wang, Parthav Jailwala, Thomas Meyer, Justin Lack, Hidetaka Ohnuki, Giovanna TosatoCulture Collection (ATCC, Manassas, VA, USA) HT29 (Cat# HTB-38), HCT116 (Cat# CCL-247), DLD1 (Cat# CCL-221), SW480 (Cat# CCL-228), SW620 (Cat# CCL-227), RKO (Cat# CRL-2577), SK-CO-1 (Cat# HTB-39), and the human

(8) Synthesis and Characterization of Sulfonamide-Schiff Bases, and Investigation of Cytotoxic, Antioxidant, HDAC, and Apoptotic Activities in Human Colon Cancer Cells (DLD-1 and HT-29)Arch Pharm (Weinheim)April 10, 2026Seda Mesci, Berna Kocaman, Aliye Gediz Erturk, Emine Bagdatli, Burak Yazgan, Tuba YildirimActivity 4.2.1 Cell Culture and Cytotoxic Activity (MTT and WST‐8 Assay) Colon cancer cell lines DLD‐1 (ATCC:CCL‐221), HT‐29 (ATTC:HTB‐38), and normal cell line CCD‐18Co (ATCC:CRL‐1459) used in this study were obtained

(9) The lipid transfer protein STARD7 controls intestinal tumor development in a context-dependent mannerEMBO Molecular MedicineMarch 30, 2026Kateryna Shostak, Yu Chen, Chloé Maurizy, Gilles Rademaker, Xinyi Xu, Arnaud Blomme, Pierre Close, Olivier Renson, Matthias Van Hul, Patrice D Cani, et al.line,ATCC,HTB-38,HTB-38 SW480 cell line,ATCC,CCL-228,CCL-228 COLO205 cell line,ATCC,CCL-222,CCL-222 DLD1 cell line,ATCC,CCL-221,CCL-221 HCT15 cell line,ATCC,CCL-225,CCL-225 Recombinant DNA,Recombinant DNA,Recombinant DNA,Recombinant

(10) Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumorsiScienceMarch 20, 2026Lamberto De Boni, Sally Claridge, Shalini Nath, Kassianne Tofani, Benjamin D. Stein, Eric Park, Sabrina Steiner, Olivier Elemento, Chantal Pauli, Benjamin D. HopkinsCell lines,Experimental models: Cell lines ,, K8484,Lab of Kenneth P. Olive,N/A DLD-1,ATCC,Cat# CCL-221 HCT116,ATCC,Cat# CCL-247 MIA PaCa-2,ATCC,Cat# CRL-1420 PANC-1,ATCC,Cat# CRL-1469 AsPC-1,ATCC,Cat#

(11) Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiotaEMBO ReportsMarch 13, 2026Liz M Garcia-Peterson, Alicia S Wellman, Xiaojiang Xu, Ming Ji, Caroline Duval, Igor Shats, Xiaoyue Wu, Thomas A Randall, Hamed Bostan, David Cunefare, et al.SIRT1 KO DLD1 human colorectal cell lines,"(Ren et al, 2017)","Original DLD1 cells were from ATCC (cat# CCL-221), routinely tested in the lab for mycoplasma contamination" "SIRT1 PKO mice, Sirt1f/f;Defa6-Cre+",This

(12) Postbiotic Metabolites from a 31-Strain Lactobacillus/Bifidobacterium Co-Culture Attenuate DSS Colitis with Barrier- and Circadian-Linked Transcriptomic SignaturesBiology (Basel)March 5, 2026Shuhei Ueda, Takumi Iwasawa, Kaho Ohki, Satoshi Takeda, Ryohma Tsuchiya, Shunsuke Sakuraba, Kazunori Kato, Tomoaki ItoIn Vitro Human colorectal cancer cell lines HCT-116 (ATCC, Manassas, VA, USA; CCL-247) and DLD-1 (ATCC; CCL-221) were cultured in RPMI 1640 (Nacalai Tesque, Kyoto, Japan; 5176-25) supplemented with 10% fetal bovine

(13) BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypesMolecular CellMarch 5, 2026Brandon Chen, Drew C. Stark, Pankaj V. Jadhav, Theophilus M. Lynn-Nguyen, Benjamin S. Halligan, Nicholas J. Rossiter, Nicole Sindoni, Myungsun Shin, Joao A. Paulo, Matthew Chang, et al.HCS CellMask Deep Red Stain,Invitrogen,cat#H32721 Experimental models: Cell lines,, SW480,ATCC,CCL-228 HT1080,ATCC,CCL-121 HCT116,ATCC,CCL-247 DLD1,ATCC,CCL-221 HeLa,ATCC,CCL-2 U2OS,ATCC,HTB-96 HEK293T,ATCC,CRL-3216 Jurkat,ATCC,TIB-152 K562,ATCC,CCL-243 B16-F0,ATCC,CRL-6322 A549,ATCC,CCL-185 PA-TU8902,This

(14) Functional characterization of CASP, a CUX1 isoform, reveals its tumor-promoting role in colorectal cancer via TRIM21-mediated signalingiScienceFebruary 20, 2026Biting Zhou, Wangxiong Hu, Wei Dai, Kailun Xu, Lihong Liu, Shu Zheng, Qichun Wei, Ting ChenExperimental models: Cell lines,Experimental models: Cell lines,Experimental models: Cell lines ,, DLD-1,ATCC,CCL-221 LoVo,ATCC,CCL-229 HCT116,ATCC,CCL-247 HT-29,ATCC,HTB-38 293T,ATCC,CRL-3216 ,, Experimental models:

(15) CaMKII nucleates an osmotic protein supercomplex to induce cellular bleb expansionThe EMBO JournalFebruary 3, 2026Yuki Fujii, Yuji Sakai, Kenji Matsuzawa, Junichi IkenouchiSource,Identifier or Catalog Number Experimental models,Experimental models,Experimental models DLD1,ATCC,CCL-221 HEK293T,ATCC,CRL-3216 Walker256,Gift from Dr. Jolana Sroka, Recombinant DNA,Recombinant DNA,Recombinant

(16) Scorpio fuscus venom as a promising anticancer agent against colorectal cancerInvestigational New DrugsFebruary 2, 2026Serdar Karakurt, Cigdem Gokcek-Sarac, Sinan Kandir, Irem Mukaddes Bilgiseven, Ersen Aydın Yagmur, Hasan Ufuk Celebioglusubepithelial injection of a suspension containing 4 × 106 DLD-1 human colorectal adenocarcinoma cells (ATCC® CCL-221™) into the distal colon, while a subcutaneous xenograft (n = 6) was placed under anesthesia in the right

(17) The Gb3-synthase A4GALT is an epigenetically regulated driver of tumor invasiveness in gastrointestinal cancerBMC CancerJanuary 27, 2026Noah-David Hirsch, Markus Perl, Simon Holzinger, Christoph Barz, Stefan Enßle, Widya Johannes, Anja Conrad, Jonas J. Unterholzner, Viktoria Obermeier, Markus Tschurtschenthaler, et al.CRL-1739), and MKN45 (DSMZ, ACC 409), and the colorectal cancer lines HCT116 (ATCC, CCL-247), DLD1 (ATCC, CCL-221). HCT116, DLD1, St3051, and MKN45 cells were cultured in DMEM supplemented with 7% fetal bovine serum (FBS

(18) Basroparib inhibits YAP ‐driven cancers by stabilizing angiomotinMolecular OncologyJanuary 22, 2026Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung KimOrganization. The cell lines used in this study include SW480 (ATCC CCL‐228, RRID: CVCL_0546), DLD‐1 (ATCC CCL‐221, RRID: CVCL_0248), SW620 (ATCC CCL‐227, RRID: CVCL_0547), COLO320DM (ATCC CCL‐220, RRID: CVCL_0219),

(19) Human CCR4-NOT suppresses pervasive transcription and retrotransposable elementsbioRxivJanuary 22, 2026Shardul Kulkarni, Alexis Morrissey, Aswathy Sebastian, Oluwasegun T. Akinniyi, Cheryl A. Keller, Istvan Albert, Shaun Mahony, Joseph C. Reesewhich CCR4-NOT contributes to genome stability and integrity. Methods Cell lines DLD-1 cells (ATCC CCL-221) were purchased from ATCC, and DLD-1TIR1+ cells were a kind gift from Dr. Mary Dasso at the National

(20) Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome DoublingCancer ResJanuary 22, 2026Mathew Bloomfield, Sydney M. Huth, Daniella S. McCausland, Ron Saad, Nazia Bano, Tran N. Chau, Megan L. Sweet, Nicolaas C. Baudoin, Andrew McCaffrey, Kai Fluet, et al.potential of cancer cells that undergo WGD. Materials and Methods Cell culture and chemicals DLD1 (CCL-221; RRID: CVCL_0248) and HCT116 (CCL-247; RRID: CVCL_0291) cells were purchased from the ATCC and cultured

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DLD-1 from ATCC

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