CCD-18Co from ATCC

Product Specs
ItemCCD-18Co
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberCRL-1459
TypeCell Biology
SpeciesHomo sapiens
TissueColon
Cell LineCCD-18Co
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Colon
Cell TypeColonocyte
Age2.5 months
DiseaseNormal
ApplicationsThis non-malignant cell line can be used in the Gastrointestinal (GI) Barrier Model

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Synthesis and Characterization of Sulfonamide-Schiff Bases, and Investigation of Cytotoxic, Antioxidant, HDAC, and Apoptotic Activities in Human Colon Cancer Cells (DLD-1 and HT-29)Arch Pharm (Weinheim)April 10, 2026Seda Mesci, Berna Kocaman, Aliye Gediz Erturk, Emine Bagdatli, Burak Yazgan, Tuba YildirimAssay) Colon cancer cell lines DLD‐1 (ATCC:CCL‐221), HT‐29 (ATTC:HTB‐38), and normal cell line CCD‐18Co (ATCC:CRL‐1459) used in this study were obtained from Gebze Technical University and SAP Institute (Türkiye). Cell

(2) Developing a protocol to counteract spontaneous in vitro activation of intestinal fibroblasts using design of experimentsnpj Biomedical InnovationsMarch 31, 2026Zahra Mohammadalizadeh, Samanvitha Sudi, Daniel A. Basto Moreno, Katherine Bauer Estrada, Morgenne Almonte, Kaitlin C. Fogg, Ana Maria Porrasculture CCD-18Co colonic fibroblasts (a cell line isolated from a healthy female donor) were obtained from ATCC (CRL-1459). For the spontaneous activation experiment, a subset of the cells was seeded on TCPS immediately after

(3) Lipid Droplets as Cellular Sensors of Lipid Metabolic Reprogramming in Colon Cancer: Insights from Essential Amino Acid Supplementation Using Raman Spectroscopy and ImagingMoleculesFebruary 25, 2026Monika Kopeć, Karolina Beton-Mysur, Beata Brożek-Płuskain this study, were purchased from MERCK (Darmstadt, Germany). 3.2. Cell Culturing CCD-18Co (ATCC® CRL-1459™) and Caco-2 cell lines were acquired from ATCC (Manassas, VA, USA) and cultured according to their

(4) Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in CancersAdvanced ScienceFebruary 13, 2026Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei YanJanuary 2020. Normal colon fibroblast cells (CCD‐18Co, RRID: CVCL_2379) was obtained from the ATCC (CRL‐1459) in May 2016. Human colorectal carcinoma (HCT‐15, RRID: CVCL_0292; HCT‐116, RRID: CVCL_0291) were obtained

(5) RCC1 Domain‐Containing Protein 1 Promotes Colon Cancer Malignant Progression by Activating Autophagy‐Dependent WNT5A Secretion in Cancer‐Associated FibroblastsJournal of the Royal Society of New ZealandFebruary 1, 2026Chao Liu, Sheng Xu, Yuanyuan Liu, Yuntian TangCCL‐247, American Type Culture Collection, ATCC, USA) and CCD‐18Co normal human colon fibroblasts (Cat# CRL‐1459, ATCC) were cultured in DMEM medium (Cat# 11995065, Gibco, USA) supplemented with 10% fetal bovine serum

(6) Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted ApproachAdvanced ScienceJanuary 30, 2026Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, et al.the modeling protocol [37]. 4.9 Cell Lines and Culture Human colonic fibroblast CCD18Co (ATCC Cat# CRL‐1459, RRID:CVCL_2379, Lot Number: 70045368, contamination‐free confirmed by ATCC), derived from normal colon

(7) Unveiling the Anticancer Potential of Urolithin A in Colorectal Cancer: A Systematic ReviewOncology ResearchJanuary 19, 2026Mariana Francisco, Fernando Mendes, Diana Martins, Joana Liberalderived from a lymph node of the same patient from whom SW480 was originally established. CCD18-Co (ATCC® CRL-1459™) normal colon fibroblasts were also included in a subset of experiments for comparative analysis [19].

(8) The P2X7 Receptor Promotes Intestinal Fibrosis by Modulating the Gut Microbiota and the InflammasomeCellular and Molecular Gastroenterology and HepatologyJanuary 1, 2026Beatriz Elias Ribeiro, Isadora Schmukler Schmukler de Lima, Karen Cristina Cristina da Silva E Souza, Siane Lopes Bittencourt Bittencourt Rosas, Patrícia Teixeira Santana, Gilda Amaral, João Carlos Machado, Rodrigo Pereira Pereira de Oliveira, Camille Leal, Cristiane Thompson, et al.studies Human fibroblasts, derived from normal, non-malignant colon tissue, CCD-18Co cells (ATCC, CRL-1459), and human skin fibroblasts, HFF-1 cells (ATCC, SCRC-1041), were obtained from the American Type Culture

(9) Coffee Wastes: A Sustainable Source of Natural Compounds Suppressing Colorectal Cancer Cell ViabilityOxid Med Cell LongevDecember 28, 2025Mariavittoria Verrillo, Paola Cuomo, Cristina Pagano, Fabrizio Martora, Riccardo Spaccini, Rosanna Capparelli, Salvatore Velottowere obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA, #HTB‐38; #CRL‐1469; #CRL‐1459, respectively). All cells were grown in Dulbecco’s modification of Eagle’s medium, high glucose (DMEM;

(10) New generation probiotics: combining probiotic and biotechnological potential of Kluyveromyces marxianusApplied Microbiology and BiotechnologyNovember 24, 2025Marta Rogalska, Katarzyna Kmita, Aleksander Gryciuk, Agata Kaczmarek, Anna Katarzyna Wrońska, Jolanta MierzejewskaHCT 116 ATCC CCL-247, HT-29 ATCC HTB-38, and Caco-2 ATCC HTB-37, as well as normal ones: CCD-18Co ATCC CRL-1459 and CCD 841 CoN ATCC CRL-1790. HT-29 and HCT 116 were grown in McCoy’s 5 A (VWR International, Leuven,

(11) Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancerScientific ReportsNovember 10, 2025Hyeon Kyeong Kim, Ryung-Ah Lee, Kyung Sook Hong, Gyoung Tae Noh, Bo Young Ohincubator with 5% CO2 at 37 °C. The IL-1β-stimulated colonic myofibroblast (CCD-18Co) cell line (Cat: CRL1459, ATCC), which exhibits fibroblast morphology, was purchased from the Korean Cell Line Bank. Cells were

(12) Synthesis of a Water-Soluble BODIPY for Targeting and Assessing the Function of Endoplasmic ReticulumACS Bio & Med Chem AuOctober 15, 2025Jacopo Tricomi, Giacomo Biagiotti, Tommy Chastel, Serena Filiberti, Hana Kokot, Francesca Mancusi, Maja Žežlina, Layal Rajeh, Iztok Urbančič, Stéphane Bodin, et al.−0.25 ppm; m.p.: 128 – 132 °C. Cell Culture and Reagents Human fibroblast CCD18Co-htert cells (ATCC CRL-1459) were grown in DMEM/F12 supplemented with 10% FCS and penicillin/streptomycin antibiotics. Human medulloblastoma

(13) The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor microenvironmentCell Commun SignalOctober 1, 2025Idan Carmi, Adrián Orosz, Szabolcs Hajdó, Anikó Zeöld, Tamás Hegedűs, Dóra Kelemen-Győri, Julianna Pozsár, Tamás Tölgyes, Zoltán Wienermicroenvironment. Materials and methods Cell cultures Normal human colon fibroblasts (NCF) (CCD-18Co, CRL-1459, ATCC, Manassas, VA, USA) were cultured in DMEM, 4500 g/L glucose, GlutaMAX (Gibco, Thermo Fisher Scientific,

(14) Pistachio leaf waste transformed into a gut-targeted bioactive phytocomplexiScienceSeptember 19, 2025Mariarita Spampinato, Salvatore Furnari, Laura Siracusa, Giuseppe A. Malfa, Alfio Distefano, Enrico La Spina, Massimo Gulisano, Pio Maria Furneri, Virginia Fuochi, Ignazio A. Barbagallo601/C.E.). CCD18Co cell line and culture maintenance Non-transformed human colon fibroblasts CCD-18Co (CRL-1459), derived from 2.5 months old black female infant, were purchased from ATCC Company (Manassas, Virginia,

(15) Small Structural Changes in Chili-Derived Capsaicin Resulting in Nonivamide Analogs of Significantly Improved Cytotoxicity and Good Tumor/Non-Tumor Cell SelectivityMoleculesAugust 25, 2025Niels V. Heise, René Csuk, Thomas MuellerMCF7 (ATCC—HTB-22) were cultivated in RPMI1640 medium, non-malignant human fibroblasts CCD18Co (ATCC—CRL-1459) were grown in MEME (both from Sigma-Aldrich, St. Louis, MO, USA). Both media were supplemented with

(16) Spectroscopic Insights into the Localization and Photodynamic Efficacy of Aluminum Tetrasulfonated Phthalocyanine for Colorectal Cancer TherapyJ Phys Chem BAugust 21, 2025K. Beton-Mysur, A. Jarota, M. Wolszczak, B. Brozek-Pluskaof photosensitizers. Materials and Methods Cell Lines and Cell Culture CCD-18Co cell line (ATCC CRL-1459) was purchased from ATCC: The Global Bioresource Center. CCD-18Co cell line was cultured using ATCC-formulated

(17) Effects of Hydatid Cyst Fluid on Inflammation and Epithelial-Mesenchymal Transition in Colorectal Adenocarcinoma (Caco-2) Cell LineActa ParasitolJuly 7, 2025Emin Yagmur, İpek Baysal, Serra Örsten, Fatma İnanç Toluncolorectal adenocarcinoma (Caco-2, HTB-37™ ATCC, U.S.A) cell line and the human colon epithelial (CoEpi, CRL-1459™ ATCC, U.S.A) cell lines were used in the study. The cells were suspended in a DMEM medium containing

(18) Kiperin Postbiotic Supplement-Enhanced Bacterial Supernatants Promote Fibroblast Function: Implications for Regenerative MedicineBiomedicinesJune 10, 2025Lutfiye Karcioglu Batur, Cuneyd Yavas, Yağmur Ekenoğlu Merdan, Ashabil Ayganobtained from ATCC (SCRC-1041), and CCD-18Co human colon fibroblasts cells which were obtained from ATCC (CRL-1459). All cell lines were cultured in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (FBS

(19) Glucosinolates from Broccoli By-Products Obtained by Pressurized Liquid Extraction Exert Anti-Inflammatory Activity on Non-Malignant Colonic MyofibroblastsPlants (Basel)June 3, 2025María Borja-Martínez, Jesús Lozano-Sánchez, Rosa Quirantes-Piné, Lorena Almagro, María A Pedreño, Ana B. Sabater-JaramL−1. 4.6. CCD-18Co Cell Culture and Anti-Inflammatory Assays Human colon-derived CCD-18Co (ATCC® CRL1459™) myofibroblast cells were obtained from ATCC (Manassas, VA, USA). The cells were maintained in Eagle’s Minimum Essential Medium (EMEM

(20) Kiperin Double-Hydrolyzed Collagen as a Potential Anti-Tumor Agent: Effects on HCT116 Colon Carcinoma Cells and Oxidative Stress ModulationCurr Issues Mol BiolMay 15, 2025Lutfiye Karcioglu Batur, Cuneyd Yavas, Nezih HekimCCD-18Co human colon fibroblasts cells, which were used as control group, were obtained from ATCC (CRL-1459). CCD-18Co and HCT116 cells were cultured in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with

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CCD-18Co from ATCC

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