CHON-001 from ATCC

Product Specs
ItemCHON-001
CompanyATCC
Price $295.00Supplier Page View Company Product Page
Catalog NumberCRL-2846
TypeCell Biology
SpeciesHomo sapiens
TissueLong bone, Cartilage
DiseaseNormal
Cell LineCHON-001
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Cartilage
Cell Typefibroblast
Age18 weeks gestation

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Mitochondrial dysfunction activates ADAMTS-5 expression via mt-dsRNA-PKR-Spi-1 axis in osteoarthritic chondrocytesiScienceJune 19, 2026Yulong Mu, Shuaichen Yan, Yizhe Wang, Boning Liang, Rui Tang, Huapu Yang, Liang Ma, Yuankai Zhang, Deqiang Lilines,Experimental models: Cell lines,Experimental models: Cell lines ,, SW1353,ATCC,HTB-94 CHON-001,ATCC,CRL-2846 HEK293T,ATCC,CRL-11268 ,, Experimental models: Organisms/strains,Experimental models: Organisms/strains,Experimental models

(2) Novel KIF22 Variants Disrupt Mitosis in Human Chondrocytes and Expand SEMDJL2 MechanismsbioRxivMarch 16, 2026Amila Šemić, Kazette Yuen Yu Yuen Yu Chan, Pricila Bernardi, Karina C. Silveira, Cynthia Silveira, Denise P. Cavalcanti, Peter Kannu, Jason Stumpffprograms. MATERIALS AND METHODS: Cell culture and transfections CHON-001 cells were purchased from ATCC (CRL-2846). CHON-001 cells were cultured at 37°C with 5% CO2 in MEM-α medium (Life Technologies, 12561072) supplemented

(3) 3D-Printed Biohybrid PE/PCL Biphasic Osteochondral Plug for Knee Cartilage RepairACS Materials AuMarch 11, 2026Jiayi Guo, Asyraf Abbas, Clara Barbut, Eun Ju Park, Qifeng Lim, Tingyi See, Lincoln Liow, Biyan Zhang, Peili TeoChondrocytes (CHON-001) Proliferation Assay Human chondrocytes (CHON-001) were purchased from ATCC (Cat No: CRL-2846) and maintained in complete media (Dulbecco’s Modified Eagle’s Medium supplemented with 10% Fetal Bovine

(4) Identification and functional analysis of hub genes in knee osteoarthritis via bioinformatics and experimental validationFront BioinformDecember 17, 2025Shanyong Jiang, Jingjing Cao, Jianshu Lu, Jianxiao Liang, Lianxin Li, Yanqiang Song, Jincheng Gao, Baoen Jiangand treatment In vitro experiments were conducted using the human chondrocyte cell line CHON-001 (CRL-2846, ATCC, Manassas, VA, United States). Cells were cultured in RPMI-1640 medium supplemented with 10% fetal

(5) Release and Cytocompatibility Study of New Hybrid Materials Based on Ferulic Acid for Biomedical UseInternational Journal of Molecular SciencesAugust 30, 2025Federico Barrino, Federica Giuliano, Clelia Dispenzaof each sample to untreated cells (CTR) as a percentage. The cell line used was as follows: CHON-001–CRL-2846. “CHON-001” is a chondrocyte cell line with a fibroblast-like morphology that was isolated in 2001 from

(6) lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytesOpen Med (Wars)June 12, 2023Xuefeng Zhang, Zhikun Wang, Binbin Wang, Jingyi Li, Hui Yuanmicroscope. The cells at P2/P3 passage were used in all experiments. Human chondrocyte cell line CHON-001 (CRL-2846) was procured from ATCC. CHON-001 cells were grown in DMEM containing 0.1 mg/mL G-418 (10131027, Gibco,

(7) Metals-triggered compound CDPDP exhibits anti-arthritic behavior by downregulating the inflammatory cytokines, and modulating the oxidative storm in mice models with extensive ADMET, docking and simulation studiesFrontiers in PharmacologyNovember 23, 2022Syed Shams ul Hassan, Syed Qamar Abbas, Ishaq Muhammad, Jia-Jia Wu, Shi-Kai Yan, Fawad Ali, Muhammad Majid, Hui-Zi Jin, Simona Bungau100 2.8 Chondrocytes cell line and cell culture CHON-001 cells were purchased from ATCC (Cat No. CRL-2846) and cultured according to instructions. Cells were grown in a complete DMEM medium enhanced with 1%

(8) Isoprenaline and salbutamol inhibit pyroptosis and promote mitochondrial biogenesis in arthritic chondrocytes by downregulating β-arrestin and GRK2Frontiers in PharmacologySeptember 14, 2022Iqra Ajmal, Muhammad Asad Farooq, Syed Qamar Abbas, Jaffer Shah, Muhammad Majid, Wenzheng Jiangchondrocyte cell line CHON-001 was purchased directly from American type culture collection (ATCC, CRL-2846). Briefly, CHON-001 cells were thawed and cultured immediately in a humid incubator (5% CO2, 37°C) after

(9) Knockdown of Circ_0037658 Alleviates IL-1β-Induced Osteoarthritis Progression by Serving as a Sponge of miR-665 to Regulate ADAMTS5Frontiers in GeneticsAugust 24, 2022Ningbo Li, Yongsheng Wang, Xuejian Wuconsent from these subjects was obtained before enrolling. Human chondrocyte cell line CHON-001 cells (CRL-2846, ATCC, Manassas, VA, United States) were cultured in DMEM (30–2002, ATCC) at 37°C, 5% CO2 with 0.1 mg/mL

(10) Influence of Heat Treatment of Electrospun Carbon Nanofibers on Biological ResponseInternational Journal of Molecular SciencesJune 3, 2022Jaroslaw Markowski, Marcel Zambrzycki, Wojciech Smolka, Agnieszka Panek, Maciej Gubernat, Paweł Czaja, Mateusz Marzec, Aneta Fraczek-SzczyptaeCNFs obtained under various temperature treatment conditions, the chondrocyte cell line CHON-001 (ATCC CRL-2846) was used. The cells were cultured in an MEM medium supplemented with 20% FBS, 1% penicillin-streptomycin,

(11) Long non-coding RNA MCM3AP-AS1 protects chondrocytes ATDC5 and CHON-001 from IL-1β-induced inflammation via regulating miR-138-5p/SIRT1BioengineeredDecember 1, 2021Shi J, Cao F, Chang Y, Xin C, Jiang X, Xu J, Lu S.liquid nitrogen until RNA extraction. 2.3 Cell culture Human chondrocyte cell line CHON-001 (ATCC® CRL-2846) was purchased from the American Tissue Culture Collection (ATCC, Manassas, VA, USA), and the mouse

(12) Up-regulation of long non-coding RNA CYTOR induced by icariin promotes the viability and inhibits the apoptosis of chondrocytesBMC Complementary Medicine and TherapiesDecember 1, 2021Guoyou Wang, Lei Zhang, Huarui Shen, Qi Hao, Shijie Fu, Xia Liu

(13) Surface Modification of Carbon Nanofibers to Improve Their Biocompatibility in Contact with Osteoblast and Chondrocytes Cell LinesMaterials (Basel)October 25, 2021Wojciech Smolka, Monika Ptas, Agnieszka Panek, Malgorzata Krok-Borkowicz, Marcel Zambrzycki, Maciej Gubernat, Jaroslaw Markowski, Aneta Fraczek-Szczypta(European Collection of Cell Cultures, Salisbury, UK), and human chondrocyte cell line CHON-001 (ATCC CRL-2846). After sterilization with ultraviolet radiation (UV-C) for 30 min, the tested nanofibers were placed

(14) Circ_0045714/miR-331-3p interaction affects IL-1β-evoked human articular chondrocyte injury through regulating PIK3R3 in a ceRNA regulatory cascadeJournal of orthopaedic surgery and researchOctober 14, 2021Ding R, Zhou J, Xu J, Lu H, Zhang T, Xiang X, Shi Z.passage were harvested for use. Cell culture and transfection The immortalized HAC cell line (CHON-001; CRL-2846; ATCC, Manassas, VA, USA) was cultured in DMEM (M22650; R&D systems) containing 0.1 mg/ml G418 disulfate salt

(15) Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in ChondrocyteJournal of Microbiology and BiotechnologyJune 28, 2021Jianqing Jiang, Mingsong CaiCell Culture The human chondrocyte line CHON-001 was bought from American Type Culture Collection (ATCC; ATCC CRL-2846, USA). Cells were cultured in Dulbeccós Modified Eaglés Medium (DMEM; ATCC 30-2002, USA) supplemented

(16) Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells in vitroCancer biology & therapyApril 3, 2021Al-Ghabkari A, Narendran A.units/ml penicillin and 100 units/ml streptomycin (Gibco). Immortalized primary fibroblast cells (hTERT) (ATCC, CRL-2846) were used as a control in this study. All cell cultures were maintained at 37 °C in a humidified incubator

(17) RGS12 is required for the maintenance of mitochondrial function during skeletal developmentCell discoveryJanuary 1, 2020Yuan G, Yang S, Liu M, Yang S.anti-cleaved-CASPASE-9 (1:2000, 9509, Cell Signaling Technology). Coimmunoprecipitation ADTC5 cells (CRL-2846, ATCC) were lysed in NP-40 buffer supplemented with PIC and phenylmethylsulfonyl fluoride (Sigma–Aldrich,

(18) LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosisBioscience reportsMay 31, 2019Huang T, Wang J, Zhou Y, Zhao Y, Hang D, Cao Y.CASC2 led to up-regulated ® expression of IL-17 in cells of human chondrocyte cell line CHON-001 (ATCC CRL-2846™). In addition, overexpression of lncRNA CASC2 inhibited the proliferation, and promoted the apoptosis

(19) The diagnostic value and pathogenetic role of lncRNA-ATB in patients with osteoarthritisCellular & Molecular Biology LettersDecember 1, 2018Xiliang Dang, Liping Lian, Dongsheng Wuusing the chi-square test. LncRNA-ATB overexpression in human chondrocyte cell line CHON-001 (ATCC CRL2846) was established to study the effects on chondrocyte proliferation (using the CCK-8 assay) and viability. Results:

(20) THE IN VITRO INFLUENCE OF A PHARMACEUTICALLY ACTIVE SMALL SEA FISH EXTRACT ON APOPTOSIS AND PROLIFERATION MECHANISMS AMPLIFIED BY INFLAMMATORY CONDITIONSFARMACIAJune 30, 2018LAURA OLARIUstimuli: IL1β and TNFα. Materials and Methods Cell cultures Chondrocyte cell line CHON-001 (ATCC® CRL2846™), human normal chondrocytes from long bone cartilage. Cultivation was performed in high glucose DMEM

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CHON-001 from ATCC

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