K-562 from ATCC

Product Specs
ItemK-562
CompanyATCC
Price $431.00Supplier Page View Company Product Page
Catalog NumberCCL-243
TypeCell Biology
SpeciesHomo sapiens
TissueMarrow, Bone
Cell LineK-562
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Blood
Age53 years
DiseaseChronic Myelogenous Leukemia Cml
ApplicationsThis cell line is suitable as a transfection host. The K-562 cell line has attained widespread use as a highly sensitive in vitro target for the natural killer assay. Cultures from the ATCC stock have been shown to exhibit this sensitivity for assessing human natural killer activity. See Pross, et al. for a detailed analysis of the in vitro assay of NK cells including the mathematics of quantitation of NK cell activity

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) TNF-α deficiency underlies NK cell dysfunction in colorectal cancerOncoimmunologyDecember 31, 2026Silvia Ruggeri, Beatrice Pizzitola, Mattia Laffranchi, Laura Beltrame, Giuseppe Sciumé, Alessio Grimaldi, Enrico Fiori, Roberto Caronna, Valerio De Peppo, Gian Luca Grazi, et al.were co-cultured with K562 target cells (human chronic myeloid leukemia line lacking MHC class I, ATCC CCL-243) at a 1:2 effector-to-target ratio for 5 h at 37 °C in 5% CO₂. After 1 h, monensin (50 μM, BD Biosciences)

(2) Development of PROTACs for targeted degradation of oncogenic TRK fusionsRSC Chemical BiologyApril 16, 2026Saurav Kumar, Jiewei Jiang, Mia S. Donald-Paladino, Joy Chen, Andrea Gutierrez, Alexander J. Federation, Frank Szulzewsky, Eric C. Holland, Fleur M. Ferguson, Behnam Nabetbovine serum, 100 U mL−1 penicillin, and 100 µg mL−1 streptomycin at 37 °C with 5% CO2. K-562 (ATCC, #CCL-243) cells were cultured in Iscove's modified Dulbecco's medium (IMDM) supplemented with 10% fetal bovine

(3) Engineering of genetically encoded programmable calcium channel inhibitory bindersNat CommunApril 13, 2026Xiaoxuan Liu, Sher Ali, Tien-Hung Lan, Decheng Wang, Brendan McKee, Tatsuki Nonomura, Siyao Liu, Feng Zhao, Michael X. Zhu, Yun Huang, et al.medium (RPMI 1640, Corning, USA) supplemented with 10% FBS. Raji cells (ATCC, CCL-86) and K562 (ATCC, CCL-243) cells were purchased from ATCC and cultured at 37 °C with 5% CO2 in RPMI 1640 supplemented with 10%

(4) CRISPR activation screens map the genomic landscape of cancer glycome remodelingCell GenomicsApril 8, 2026John Daly, Lidia Piatnitca, Mohammed Al-Seragi, Vignesh Krishnamoorthy, Simon Wisnovsky99 LN-229,ATCC,CRL-2611 THP-1,ATCC,TIB-202 Lenti-X 293T cell Line,Takara Bio,632180 K-562,ATCC,CCL-243 ,, Recombinant DNA,Recombinant DNA,Recombinant DNA ,, "Human CRISPRa-v2 pooled library (half-library,

(5) Lupane Triterpenes with Antileukemia Activity from Maytenus quadrangulataACS OmegaApril 7, 2026Sandy V. M. Quintão, Mariana G. de de Aguilar, Lucas C. Souza, Túlio R. Freitas, Maria E. C. dos S. Jardim, Lohanne B. E. de Souza, Adriano de P. Sabino, Lucienir P. Duarte, Grasiely F. de Sousatumor cell lines THP-1 (acute monocytic leukemia, ATCC-TIB-202TM) and K-562 (chronic myeloid leukemia, ATCC–CCL-243), by the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] colorimetric assay. Following

(6) Doxorubicin enhances adipogenesis in an FGF2-dependent manner and induces a tumour-promoting secretory phenotypeJournal of Bone OncologyApril 1, 2026Lauren M. Kreps, Edward Yakubovich, Huijun Zhao, Selam Yimer, Edward Yang, Juliet Cruz, Barbara Vanderhyden, Christina L. Addisonprostate tumour cells (ATCC CRL-1435), 4T1 breast tumour cells (CRL-2539) and K562 leukemia tumour cells (CCL-243) were obtained from the American Type Culture Collection (ATCC, Manassas, VA). PC3 cells were maintained

(7) Evidence that dengue virus envelope protein in patient platelets originates from infection of megakaryocytic precursorsPLoS OneApril 1, 2026Marcos Alvarado Silva, Tannya Karen Castro Jimenez, Edwin Antonio Lopez Kelly, Nallely Diaz Lima, José Alberto San Juan Luis, Diego Sait Cruz Hernández, Sergio Roberto Aguilar Ruiz, José Bustos Arriagamegakaryopoiesis; MEG-01 cell line (ATCC CRL-2021) was used as a model of megakaryoblast and K562 cells (ATCC CCL-243) as a model of the megakaryocyte-erythroid progenitor stage [12,13]. All infections were performed in

(8) IL-7Rα signaling potentiates the anti-tumor activity of NK92 cellsFrontiers in ImmunologyMarch 30, 2026Chunli Wang, Seokmin Kim, Ling-Zu Kong, Inhwan Jang, Seona Jo, Sunyoung Lee, Soo Yun Lee, Kee K. Kim, Tae-Don KimATCC®HTB-177™), MOLT 4 (human T lymphoblast cell line, ATCC®CRL-1582™), K562 (human leukemia cell line, ATCC®CCL-243™), and HEK-293T cells (ATCC®CRL-11268™) were acquired from the American Type Culture Collection (Manassas,

(9) Differential Modulation of JAK/STAT3 Signaling and BCL-2 Family Proteins by Tetracycline Analogues in Leukemia ModelsPharmaceuticsMarch 28, 2026Zienab M. Hassan, Doste R. Mamand, Hoda W. El-Gawly, Nagla A. El-Sherbeeny, Hala M. F. Mohammad, Mohamed K. Elkherbetawy, Oscar P. B. Wiklander, Moustapha Hassanare provided in the Supplementary Materials. 2.2. Cell Culture The leukemia cell lines K562 (ATCC, CCL-243), KG-1a (ATCC, CCL-246.1), and Jurkat (ATCC, TIB-152) were selected to represent major hematological malignancy

(10) From byproduct to biotherapeutic: Comparative study of buffy coats and leukoreduction system chambers for NK cell-based immunotherapiesiScienceMarch 20, 2026Maximiliane Tietze, Maria Schuldt, Martina Wohsmann, Kristina Hölig, Helmut Hanenberg, Torsten Tonn, Jiri Eitler, Joel G. Rurik, Stephan R. Künzelpenicillin-streptomycin (PAN Biotech, Aidenbach, Germany) under humidified conditions at 37°C and 5% CO2. K562 (ATCC CCL-243) were maintained in RPMI 1640 supplemented with 10% fetal bovine serum (Bio&Sell, Feucht/Nürnberg, Germany),

(11) Potential Mechanisms of MAP Kinase JNK's Involvement in Modulating Cancer Cell Fate in a Cisplatin Concentration-Dependent MannerPharmaceuticals (Basel)March 20, 2026Monika Tenkutytė, Audronė V. Kalvelytė, Aurimas StulpinasService GMBH, Eppelheim, Germany, #300114; male), chronic myeloleukemia K-562 (ATCC, Manassas, VA, USA, #CCL-243 TM; female), small cell lung carcinoma SHP-77 (ATCC #CRL-2195 TM; male), skin epidermoid carcinoma A431

(12) Mistranslation from an endogenous tRNA variant in human pan-genome cell linesNucleic Acids ResMarch 17, 2026Peter Rozik, Henry Moore, Jeremy T Lant, Kyle S Hoffman, Sarah K Schultz, Baasil Afzal, Patricia P Chan, Lauren E Flynn, Ilka U Heinemann, Todd M Lowe, et al.ATCC), in murine neuroblastoma Neuro-2a (N2a) cells (CCL-131, ATCC), or in human K562 lymphoblast cells (CCL-243, ATCC) as indicated. Lymphoblastoid cell lines (β-lymphocytes) from individuals in the 1000 genomes

(13) Combining lenalidomide with IL-2 family of cytokines enhances activating receptor and perforin/granzyme expression in NK cellsPLoS OneMarch 12, 2026Alexandra Calescibetta, Robert Dalton, Nicole Fortenbery, Grace Ward, Sean Christiansen, Xianghong Chen, Pingyan Cheng, Tiffany Razabdouski, Annelise J. Glode, Nhan Tu, et al.United States). To assess the cytotoxic potential of NK cells (primary or cell lines) we used K562 (cat# CCL-243, ATCC, Manassas, Virginia, United States, RRID:CVCL_K562), 721.221 (cat# CRL-1855, ATCC, Manassas, Virginia,

(14) ZAP targets aberrant mRNA transcripts encoding proteins with defective signal peptides for degradationThe EMBO JournalMarch 12, 2026Akruti Shah, Aaztli R Coria, Britnie Santiago Membréno, Emilien Orgebin, Jennifer T Miller, Wilfried Guiblet, Colin Chih-Chien Wustudy, Flp-In T-REx HeLa expressing GRN WT or GRN-A9D reporter,This study, K562 cells (H. sapiens),ATCC,CCL-243 "K562 expressing PPL-WT, PPL-Δ2L or PPL-Δ4L reporter",This study, K562 ZAP KO cells,This study, K562

(15) Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cellsmBioMarch 11, 2026Mary Ann Checkley, Benjamin G. Luttge, Cheryl M. Cameron, Konstantin S. Leskov, Curtis Dobrowolski, David N. Wald, Deborah McMahon, Ghady Haidar, Michele D. Sobolewski, P. Nathan Enick, et al.pNLAD8-GFP-Nef (AD8gNef) (108, 109). Cell lines HIV-transduced Jurkat E6.1 cells (3C9) (110), K562 ATCC CCL-243, C9.K562-mbIL21, and NKF were maintained in RPMI-1640 (Gibco Fisher Scientific) with 10% FBS (Gemini

(16) Screening of kinase inhibitors in the triple negative KRAS G13D-mutated MDA-MB-231 breast cancer cell lineScientific ReportsMarch 11, 2026Sandra Stickler, Marie-Therese Eggerstorfer, Maximilian Rieche, Sinem Arslan, Maryana Teufelsbauer, Martin Hohenegger, Lukas Weigl, Gerhard Hamiltontriple negative breast cancer cell line MDA-MB-231 (ATCC HTB-26) carrying a KRAS G13D mutation and K-562 (ATCC CCL-243), a chronic myelogenous leukemia cell line harboring a Philadelphia chromosome, were obtained from the

(17) CD70-Targeting CAR NK Cells Overcome BCMA Downregulation and Improve Survival in High-risk Multiple Myeloma ModelsBlood Cancer DiscoveryMarch 4, 2026Paul Lin, Sunil Acharya, Francia Reyes-Silva, Rafet Basar, Nadima Uprety, Luz Yurany Moreno Rueda, Pei Lin, April L. Gilbert, Pinaki P. Banerjee, Dexing Fang, et al.#CRL-3580, RRID: CVCL_1600) were provided by R.Z. Orlowski, MD Anderson Cancer Center. K562 cells (cat. #CCL-243, RRID: CVCL_0004) were obtained from the ATCC. MM.1S, U266B1, and NCI-H929 cells were cultured in RPMI 1640 medium

(18) Protocol to generate human stem cell-derived CD70-directed allogeneic CAR-NKT cells for treating renal cell carcinomaSTAR ProtocolsMarch 1, 2026Yan-Ruide Li, Lili YangaAPC was created by genetically modifying the K562 human chronic myelogenous leukemia cell line (ATCC, CCL-243) to overexpress human CD80, CD83, CD86, 4-1BBL co-stimulatory molecules, and CD70. K562 cells are commonly

(19) TIGIT Blockade Potentiates the Anti-Leukemic Activity of Exercise-Mobilized Donor Lymphocytes and Expanded γδ T-CellsCancers (Basel)February 28, 2026Grace M. McKenzie, Josie Voss, Emmanuel Katsanis, Richard J. Simpson, Forrest L. BakerExperiments K562-luc2 and γδ T-cell preparation for injection: The HLA-deficient CML cell line K562-luc2 (ATCC: CCL-243) was used to induce a widespread tumor in mice and used as the target cell in cytotoxicity assays and

(20) Pharmacological Modulation of Autophagy Can Sensitize Acute Lymphoblastic Leukemia Cell Lines to DexamethasoneCancers (Basel)February 28, 2026Liliana Torres-López, Miguel Olivas-Aguirre, Alejandro Chávez-Gutiérrez, Oxana DobrovinskayaRS4;11 (female, 3-year-old, ATCC®CRL-1873™). Chronic myeloid leukemia: K562 (female, 53-year-old, ATCC®CCL-243™). Cells were maintained in suspension using Advanced RPMI 1640 medium containing 5% heat-inactivated

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K-562 from ATCC

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