Shourya Roy Burman is a biomolecular engineer who works as a research fellow in Eric Fischer’s lab at the Dana-Farber Cancer Institute where he develops methods to design new protein degradation systems. He obtained his Ph.D. from Jeffrey Gray’s group at the Johns Hopkins University where he developed computational algorithms for protein docking as a part of the Rosetta macromolecular modeling suite. At Dana-Farber, he is using these algorithms and related methods to create a pipeline for rational PROTAC design. Recently, using a machine learning-based approach, in collaboration with Shirley Liu’s lab, he identified that the positioning of ubiquitination sites on a target protein vis-a-vis the E3 ubiquitin ligase complex is the single most important intrinsic feature that determines its tractability to targeted degradation approaches. Besides, PROTAC design, Shourya is creating synthetic degradation tags to regulate expression levels in engineered cell therapies for which he was awarded the Cancer Research Institute Irvington Postdoctoral Fellowship.