Leica DMi1 Inverted Microscope from Leica Microsystems

Product Specs
ItemLeica DMi1 Inverted Microscope
CompanyLeica Microsystems
Price Get Pricing Get Quote for this Product
Catalog NumberDMi1
QuantityEA
TypeAutomated, Phase Contrast, Brightfield
ApplicationsCell biology / Developmental biology
Objectives4x, 5x, 10x, 20x, 40x Phase Contrast
Eyepiece10x/20 Non-focusing, 10x/20 Focusing
Optical SystemInfinity corrected (HCS)
Light Source5W LED
Dimensions(WxDxH) 248 x 535 x 543 mm
FilterGreen and Yellow
Features (standardized)Camera Compatible, LED Illumination
Validated ApplicationsMicroscopy, Phase Contrast, Live Cell Imaging

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Leica Microsystems

10 Parkway North Blvd., Suite 300

Deerfield, Illinois 60015

United States

Phone: 800 248 0123

Company Profile

Website: www.leica-microsystems.com

(1) Targeted delivery of lupeol via hyaluronic acid-modified ZIF-8 for anti-hepatic fibrosis therapyMaterials Today BioJune 1, 2026Bianbian Liao, Dongmei Qin, Rubing Houfor 24 h. Finally, images of the scratched areas were captured using an inverted microscope (Leica, DMI1, China). 2.12 Glycolysis inhibition in aHSCs In this therapeutic study, LX-2 cells were co-incubated

(2) Ultrasound-guided nanocomposite hydrogel injection to enhance nerve repair via temporal delivery of a colony-stimulating factor 1 receptor inhibitorJournal of Controlled ReleaseMay 10, 2026Zhi He, Olawale A. Alimi, Tianshu Pan, Mitchell Kuss, Bryan T. Hackfort, Mena A. Krishnan, Yiran Li, Bo Liu, Bin Duannerve tissues were then sectioned transversely into 1 μm and 100 nm thick slices for TB staining imaging (DMi1, Leica) and TEM imaging (Hitachi HT-7800), respectively. For quantitative analysis of TEM images, three

(3) Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulationLife Science AllianceMay 1, 2026Noemi Garcia Garcia, Thanh Ha Vy Nguyen, Dane Richey, Emily F Cox, Jon Coca Juaristi, Cody Ashby, Analiz Rodriguez, Katie R Ryantranswell were removed with a cotton swab. Invaded cells were imaged directly from transwells using a Leica DMi1 inverted microscope equipped with a Leica Hi Plan 10x air objective, and captured using Leica Application Suite software

(4) Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosisReprod Biol EndocrinolApril 23, 2026Juste Cioraityte, Lennard Schröder, Zeinesh Beimenbetova, Anna T. Rückl, Susanne Beyer, Johanna Becker, Thomas Kolben, Sven Mahner, Mirjana Kessler, Simon Kecksteintriplicate, and averaged CT values were used for analysis. Brightfield images were captured using a Leica DMi1 microscope. RNA isolation After the organoids were retrieved from Cultrex as previously described,

(5) KRT16 and APOA1: key regulators of proliferation and lipid metabolism in non-small cell lung cancerOpen Life SciApril 17, 2026MeiE Yu, Ling Zhu, YingXiao Wu, MengLing Li, QiongYing Wei(Thermo Fisher Scientific, USA) for 72 h. GFP expression was confirmed using a fluorescence microscope (DMi1; Leica, USA). Screened cells were subjected to stable passaging to produce A549 cells that consistently

(6) Theranostic vNAR-Based Immunoconjugates Achieve Selective Intracellular Cisplatin Delivery in Embedded 3D HER2-Positive Breast Cancer In Vitro ModelPharmaceuticals (Basel)April 17, 2026Andrea C. Alfonseca-Ladrón de Guevara, Alejandro Manzanares-Guzmán, Jessica A. Badillo-Mata, Mirna Burciaga-Flores, Pavel H. Lugo-Fabres, Tanya A. Camacho-Villegaswith 1× PBS and allowed to air-dry in the dark. Immunofluorescence imaging was performed using a Leica DMi1 microscope in sequential acquisition mode to minimize background interference. Image analysis was carried

(7) Cultivation of Limnospira platensis (Spirulina) in Full Seawater with Medium Recycling: A Promising Source of Protein and Phycocyanin for Arid Coastal RegionsMar DrugsApril 16, 2026Monserrat Alemán, Marianna Venuleo, Juan Luis Gómez-Pinchetti, Eduardo Portillo, Flavio Guidisignificant morphological changes were observed by microscopic observation during the experiment (Leica DMi1 microscope, 40× magnification; Leica Microsystems, Wetzlar, Germany). 4.2.3. Experimental Steps Toward

(8) From Luminal to Triple Negative: 3D Spheroids Reveal Molecular and Phenotypic Differences Across Breast Cancer SubtypesInt J Mol SciApril 15, 2026Maria Miguel Castro, Letícia Maretti, Catarina Esquível, Bárbara Sousa, Carmen Jerónimo, Andrew J. Ewald, Joana Paredeseach well. 4.3. Breast Cancer Spheroids’ Size Measurement Brightfield images were acquired using a DMi1 inverted microscope (Leica, Wetzlar, Germany) at 48 h post-seeding. At the same time point, additional

(9) Mono- and co-infections of primary porcine respiratory cells with Bordetella bronchiseptica and Streptococcus suis are not affected by the dermonecrotic toxinInfection and ImmunityApril 15, 2026Désirée Schaaf, Muriel Dresen, Yenehiwot Berhanu Weldearegay, Jeannine Biermann, Susan L. Brockmeier, Wolfgang Baumgärtner, Michael Jarek, Peter Valentin-Weigand(Leine-Fleisch GmbH) as previously described (8). Ciliary activity was monitored by light microscopy (Leica DMi1; Leica), and slices with at least 80% ciliary activity were chosen for infection experiments. Prior

(10) Small and medium/large glioblastoma extracellular vesicles differentially regulate endothelial and mitochondrial function in blood-brain barrier and peripheral vasculature modelsJ NeurooncolApril 14, 2026Deimantė Kulakauskienė, Karolina Kriaučiūnaitė, Zbigniev Balion, Edgaras Stankevičius, Aistė Jekabsonewere incubated under standard conditions. Images of the wound were taken at 0 and 9 h using a Leica DMi1 light microscope (Germany) at 4x magnification. The wound area was manually traced in the captured images

(11) Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathwayOncol RepApril 14, 2026Yongyang Yun, Xing Ji, Shuai Hu, Tianyu Wu, Yixiao Liu, Zheng Li, Zhoujie Sun, Peimin Zhou, Lei Yang, Wei Yuroom temperature. Colonies containing >50 cells were counted manually under a light microscope (Leica DMi1; Leica Microsystems GmbH). Clonogenic efficiency was quantified as the number of colonies per well.

(12) A Triple-Modality Peptide-Antibiotic-Phage Therapy Eradicates Multidrug-Resistant Serratia marcescens BiofilmsbioRxivApril 9, 2026Aryaan P. Duggal, Adit B. Alreja, Isha Vashee, Hayley Nordstrom, Erin Harrelson, Nakia Fallen, Kari-Ann Takano, Ryan A. Blaustein, Derrick E. Fouts, Norberto Gonzalez-Juarbewashed three times with PBS. Biofilms were then air-dried for 5–10 minutes before imaging on a Leica DMi1 microscope. To quantify biofilm biomass, 200 μL of 70% ethanol was added to each well to extract the

(13) PLLP inhibits the progression of wild-type p53 gastric cancer by reducing p53 protein ubiquitination by binding to TRIM59Journal of Biological ChemistryApril 1, 2026Zhenhao Quan, Lin Lin, Feipeng Xu, Caijin Zhou, Renwei Huang, Kaiyu Sun, Haiping Jiang15 min, and sealed with glycerol. The images of the sections were collected by a microcamera system (DMI1, Leica), and the percentage of positive apoptotic cells in the pictures was calculated. Immunohistochemical staining

(14) Cinobufotalin reduces glioblastoma resistance to temozolomide by inhibiting the CCL5-mediated PI3K/Akt/mTOR signaling pathwayTranslational Cancer ResearchMarch 31, 2026Jiwei Sun, Xianyuan Ma, Jian Song, Yesen Zhang, Ning Li, Yulong Li, Xiang Zhang, Yi Hancells were counted in six randomly selected areas under an inverted microscope (Leica, Shanghai, China; DMi1, SCR_017132). 5-ethynyl-2'-deoxyuridine (EDU) staining EDU staining was performed to assess cell proliferation.

(15) Differential Effects of Commercial Food-Grade Carrageenan Preparations on DSS-Induced Colitis and Gut Microbiota in MiceFoodsMarch 25, 2026Jiyu Nie, Danying Chen, Chengfeng Yu, Zengliang Jiang, Haibo Pan, Xingqian Ye, Shiguo Chenwas used to dye. The stained sections were examined and imaged using an inverted microscope (Leica DMi1, Leica Microsystems GmbH, Wetzlar, Germany) 4× and 10× magnifications. Histopathological scoring was

(16) Nested pediatric low-grade glioma cerebral organoid avatars reveal glutamatergic neuron stromal growth dependencyGenes DevMarch 23, 2026Enquan Xu, Christina Zhang, Fausto J. Rodriguez, Sonika Dahiya, Corina Anastasaki, David H. GutmannHoechst 33258 (Thermo Scientific). Samples were mounted with Immu-Mount (Fisher) and imaged using a Leica DMi1 fluorescence microscope with LAS X software. For synapsin-I and bassoon immunostaining, high-resolution

(17) Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunctionCardiovascular DiabetologyMarch 21, 2026Elena Mele, Maria Antonietta Riemma, Maria Donniacuo, Marialucia Telesca, Grazia Sorrentino, Domenico D’Amario, Filippo Scialò, Eleonora Cianflone, Donato Cappetta, Daniele Torella, et al.lipid detection. Samples were analyzed by confocal microscopy (LSM700, Zeiss) and light microscopy (DMi1, Leica). DHE, 8-OHdG, 4-HNE, and 3-NT images were processed and analysed by ImageJ for the quantification

(18) Pharmaco-genomic characterization of pancreatic and biliary tract cancer tumoroids for drug responseiScienceMarch 20, 2026Kun Fang, Wenxin Zhang, Qing Zhao, Yan Hong, Ruiqi Wang, Biyu Yang, Yangrong Zhao, Yunkai Shi, Bing Zhou, Jian Ding, et al.culture medium was changed twice a week. Tumoroid pictures were taken using an inverted microscope Leica DMi1 and Leica DFC 450C camera. Once mature, tumoroid cultures were passaged by dissociating in TrypLE Express

(19) Hydrogen sulfide attenuates oxidative stress-induced cellular senescence via the Sirt3/SOD2 signaling pathway in chronic obstructive pulmonary diseaseChinese Medical JournalMarch 20, 2026Sha Liao, Dian Chen, Huanyu Long, Simin Jiang, Jing Fan, Shurun Li, Yongfen Qi, Lixiang Xue, Yanling Ding, Yahong Chendeveloped overnight at 37°C without CO2. The cells were examined under a microscope of 200x (Leica DMi1, Wetzlar, Germany). Enzyme-linked immunosorbent assay (ELISA) The collected and processed cells, along

(20) Mumio and bladder cancer: unlocking its potential in 3D cell cultureBMC CancerMarch 14, 2026Zuzanna Fekner, Julia Sieracka, Paweł Dąbrowski, Łukasz Kaźmierski, Marta Rasmus, Arkadiusz Jundziłł, Tomasz Drewa, Dariusz Grzanka, Marta Pokrywczyńska, Tomasz Kloskowskiexcept for the shaking parameters (30 s at 500 rpm). Morphological and morphometric evaluation A Leica DMi1 inverted light microscope (Leica, Germany) was used to create photographic documentation of spheroids

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