Description
E-64-D is a cell-permeable ethyl ester of E-64-C (Prod. No. BML-PI106). The ester is hydrolyzed by intracellular esterases to produce E-64-C that inhibits calpain and cathepsins B, F, H, K, and L. E-64-D inhibits degradation of autophagic cargo inside autophagolysosomes, especially when used in combination with pepstatin (Prod. No. ALX-260-085). E-64-D combined with camostat mesylate also inhibits entry of SARS-CoV-2 in cells in vitro