HCC70 from ATCC

Product Specs
ItemHCC70
CompanyATCC
Price $551.00Supplier Page View Company Product Page
Catalog NumberCRL-2315
TypeCell Biology
SpeciesHomo sapiens
TissueBreast, Duct:Mammary gland
Cell LineHCC70
Validated Species ReactivityHuman (Hu)
Tissue (standardized)Breast
Cell Typeepithelial cell
Age49 years
DiseaseCarcinoma Ductal TNM stage IIIA grade 3
ApplicationsHCC70 is positive for the epithelial cell specific marker Epithelial Glycoprotein 2 (EGP2) and for cytokeratin 19.However, recent studies performed outside of ATCC have given conflicting results about the status of the estrogen receptor for these cells.The cells are poorly differentiated.The cells overexpress p53, and are negative for the expression of Her2-neu oncogenes.The depositor of CRL-2315 initially reported the cells were positive for estrogen receptors

Specifications/Features

Post freeze viability ≥ 50%

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling PathwaysOncology ResearchMarch 23, 2026Denisse A. Gutierrez, Elisa Robles-Escajeda, Jose A. Lopez-Saenz, Robert A. Kirken, Edgar A. Borrego, Ana P. Betancourt, Soumya Nair, Sourav Roy, Armando Varela-Ramirez, Renato J. Aguilera(ATCC, CRL-3273), RPMI-8226, MM.1S, MM.1R, U266, Rec-1, JVM-13, A549 (ATCC, CRM-CCL-185), HCC70 (ATCC, CRL-2315), HCC1419 (ATCC, CRL-2326), T47D (ATCC, CRL-2865), KMS-11, and OVCAR-5 cell lines were grown in Roswell

(2) PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive TumorigenesisCancer DiscoveryMarch 2, 2026Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang, Weihua Wang, Renlei Ji, Wendi Huang, Jiachen Wu, Yutong Li, Xiaochun Wan, et al.humidified atmosphere containing 5% CO2. Human cell lines (HEK-293T, # CRL-3216; BT549, # HTB-122; HCC70, # CRL-2315; HCC1954, # CRL-2338; MDA-MB-231, # HTB-26; MDA-MB-468, # HTB-132; and PC3, # CRL-1435) were obtained

(3) Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancerCell Rep MedDecember 16, 2025Jody Vykoukal, Yihui Chen, Mingxin Zuo, Riccardo Ballarò, Monica J. Hong, Hansini Krishna, Daniela B. Rodriquez-Perera, Hiroyuki Katayama, Ehsan Irajizad, Ranran Wu, et al.Collection),CRL-2316 HCC38,ATCC (American Type Culture Collection),CRL-2314 HCC70,ATCC (American Type Culture Collection),CRL-2315 HMLER3,Kindly provided by Dr. Susan Lindquist (MIT),Katayama et al.71 Hs578T,ATCC (American Type Culture

(4) Dual Biological Potential: Anticancer and Antibacterial Activities of Bis‐ α, ω‐Bifunctional Sphingolipids from the Marine Sponge Oceanapia ramsayiChemMedChemNovember 18, 2025Dele Abdissa Keneni, Idris Njanje, Jarmo‐Charles Julian Kalinski, Michelle Isaacs, Tarryn Swart, Candace Davison, Jo‐Anne de la Mare, Rosemary Ann Dorringtontriple‐negative breast cancer (TNBC) cell line (ATCC: HTB‐26), African‐American HCC70 TNBC cell line (ATCC: CRL‐2315), the Caucasian MCF‐7 hormone receptor‐positive (ER+, PR+, HER‐2‐) breast cancer cell line (ATCC: HTB‐22)

(5) Ferrocene thiazolidine-2,4-dione derivatives cause DNA damage and interfere with DNA repair in triple-negative breast cancer cellsPLoS OneJuly 17, 2025Nyeleti Vukea, Ogunyemi Oderinlo, Matshawandile Tukulula, Setshaba David Khanye, Adrienne Lesley Edkins, Jo-Anne de la Mare(ADME). Materials and methods Cell lines and culture conditions The TNBC cell lines, HCC70 (ATCC-CRL-2315) and HCC1937 (ATCC-CRL-223) basal triple-negative breast cancer (TNBC) cell lines were maintained as

(6) Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platformCell Reports MedicineJuly 15, 2025Yuqing Zhang, Zehua Li, Jessica Ritter, Elliott J. Brea, Navin R. Mahadevan, Deborah A. Dillon, Sung-Rye Park, Eric Minwei Liu, Michael Y. Tolstorukov, William E. McGourty, et al.HTB-26 Human: MDAMB468,ATCC,Cat# HTB-132 Human: HCC1937,ATCC,Cat# CRL-2336 Human: HCC70,ATCC,Cat# CRL-2315 Human: THP-1,ATCC,Cat# TIB-202 Mouse: 4T1,ATCC,Cat# CRL-2539 Human: H29D,Laboratory of E. Smith,N/A Human:

(7) The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cellsSci RepJuly 1, 2025Deborah Kajewole, Ho Ning Wong, Alexander von Kriegsheim, Richard K. Haynes, Jo-Anne de la Mare, Adrienne Lesley Edkins°C. Cell cultures The triple negative breast cancer cell lines HCC1937 (ATCC: CRL-2336), HCC70 (ATCC: CRL-2315), MDA-MB-231 (ATCC: HTB-26), the cervical carcinoma cell line HeLa (ATCC: CCL-2), and colon cancer cell

(8) Unique characteristics of autoantibodies targeting MET in patients with breast and lung cancerJCI InsightMay 22, 2025Michal Navon, Noam Ben-Shalom, Maya Dadiani, Michael Mor, Ron Yefet, Michal Bakalenik-Gavry, Dana Chat, Nora Balint-Lahat, Iris Barshack, Ilan Tsarfaty, et al.glutamine (Biowest), and 1% sodium pyruvate (Sartorius). The MDA-MB-468 (ATCC, HTB-132) and HCC70 (ATCC, CRL-2315) cell lines were cultured in RPMI 1640 supplemented with 10% FBS (Gibco), 1% penicillin/streptomycin

(9) Labdane Diterpenoids from Leonotis ocymifolia with Selective Cytotoxic Activity Against HCC70 Breast Cancer Cell LineDiseasesMay 1, 2025Jane Busisiwe Ncongwane, Vuyelwa Jacqueline Tembu, Comfort Mduduzi Nkambule, Douglas Kemboi, Gerda Fouche, Nyeleti Vukea, Jo-Anne de la Maremeasuring the cell viability of three breast cell lines, namely triple-negative breast cancer HCC70 (ATCC: CRL-2315), hormone receptor-positive breast cancer MCF-7 (ATCC: HTB-22), and non-tumorigenic mammary epithelial cell

(10) Discovery and biological evaluation of a novel and highly potent JAK2 inhibitor for the treatment of triple negative breast cancerJ Enzyme Inhib Med ChemApril 29, 2025Yingxiang Miao, Shudan Yang, Fang Zhang, Jindong Li, Yan ZhangMDA-MB-468 (catalogue number: HTB-132), MDA-MB-231 (catalogue number: CRM-HTB-26), HCC70 (catalogue number: CRL-2315), MDA-MB-157 (catalogue number: HTB-24), HUVECs (catalogue number: PCS-100-013). The multidrug-resistant

(11) Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC DegraderJournal of Medicinal ChemistryApril 24, 2025Yue Zhong, Huensuk Kim, Chao Qian, Ling Xie, Xian Chen, Yan Xiong, Jacqueline Hu, Matthew Chen, Ernesto Guccione, Yudao Shen, et al.MDAMB231 (HTB-26), MCF7 (HTB-22), PC-3 (CRL-1435), MCF10A (CRL-10317), BT-549 (HTB-122) and HCC70 (CRL-2315) were purchased from ATCC (American Tissue Culture Collection). PNT2 cell line (cat# 95012613) is purchased

(12) Novel Amanitin-based Antibody Drug Conjugates (ATAC®) targeting TROP2 for the treatment of Pancreatic CancerMolecular Cancer TherapeuticsApril 2, 2025Eleni Papacharisi, Alexandra C. Braun, Marija Vranic, Andreas M. Pahl, Torsten HechlerCVCL_1603) and the HER2+ breast cancer cell line MCF-7 (RRID: CVCL_0031) were purchased from ATCC [Cat. # CRL-2315 (2020), Cat. # CRL-5822 (2020)] and DSMZ [Cat. # ACC-115 (2019)], respectively. All cell lines were

(13) Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivityMolecular Systems BiologyFebruary 24, 2025Carolin Ector, Jeff Didier, Sébastien De Landtsheer, Malthe S Nordentoft, Christoph Schmal, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Thomas Sauter, Adrián E Granada,Experimental models HCC1143,ATCC,CRL-2321 HCC1806,ATCC,CRL-2335 HCC1937,ATCC,CRL-2336 HCC38,ATCC,CRL-2314 HCC70,ATCC,CRL-2315 MDAMB468,ATCC,HTB-132 BT549,Gift of Prof. Peter Sorger (Harvard), CAL51,Gift of Prof. Peter Sorger

(14) A compendium of Amplification-Related Gain Of Sensitivity genes in human cancerNat CommunJanuary 27, 2025Veronica Rendo, Michael Schubert, Nicholas Khuu, Maria F. Suarez Peredo Rodriguez, Declan Whyte, Xiao Ling, Anouk van den Brink, Kaimeng Huang, Michelle Swift, Yizhou He, et al.SK-LU-1 (cat. no. HTB-57; ATCC; female), ZR-75-1 (cat. no. CRL-1500; ATCC; female), HCC70 (cat. no. CRL-2315; ATCC; female), and MDA-MB-231 (cat. no. HTB-26; ATCC) cells were initially STR-profiled and subsequently

(15) TALEN-edited allogeneic inducible dual CAR T cells enable effective targeting of solid tumors while mitigating off-tumor toxicityMolecular TherapyNovember 6, 2024Sonal Dharani, Hana Cho, Jorge Postigo Fernandez, Alexandre Juillerat, Julien Valton, Philippe Duchateau, Laurent Poirot, Shipra Dascryopreserved in 90% albumin/10% DMSO. HCC70-GFP-Nanoluciferase were engineered from HCC70 cells (ATCC, # CRL-2315) using an in-house rLV encoding NanoLuc_T2A_EGFP construct and AMSbio (# LVP323-PBS), respectively,

(16) HuR controls glutaminase RNA metabolismNature CommunicationsJuly 4, 2024Douglas Adamoski, Larissa M. dos Reis, Ana Carolina Paschoalini Mafra, Felipe Corrêa-da-Silva, Pedro Manoel Mendes de Moraes-Vieira, Ioana Berindan-Neagoe, George A. Calin, Sandra Martha Gomes DiasHTB-130), MDA-MB-453 (ATCC HTB-131), MDA-MB-468 (ATCC HTB-132), HCC38 (ATCC CRL-2314), HCC70 (ATCC CRL-2315), HCC1806 (ATCC CRL-2335), HCC1937 (ATCC CRL-2336), and PC-3 cell lines were cultivated in RPMI 1640

(17) Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancerJournal of Cancer Research and Clinical OncologyFebruary 28, 2024María Paula Marks, Carla Alejandra Giménez, Luciana Isaja, Mariana Belén Vera, Francisco Raúl Borzone, Federico Pereyra-Bonnet, Leonardo Romorini, Guillermo Agustín Videla-Richardson, Norma Alejandra Chasseing, Juan Carlos Calvo, et al.Cat# CRL-12532, RRID:CVCL_0062), MDA-MB-468 (ATCC Cat# HTB-132, RRID:CVCL_0419) and HCC70 (ATCC Cat# CRL-2315, RRID:CVCL_1270) were a gift from Dr. Elizalde’s lab. BT474 were authenticated by the Human Cell Line

(18) Crosstalk between tumour and stroma modifies CLIC4 cargo in extracellular vesiclesJournal of Extracellular BiologyJanuary 24, 2024Vanesa C. Sanchez, Alayna Craig‐Lucas, Christophe Cataisson, Brandi L. Carofino, Stuart H. Yuspabreast cancer cell lines were purchased from American Type Culture Collection (ATCC, Manassas, VA; HCC70, #CRL‐2315; BT‐549, #HTB‐122; DU4475, #HTB‐123; HCC38 #CRL‐2314; HCC1143, #CRL‐2321; HCC1599, #CRL‐2331; HCC1806,

(19) Phytochemicals from Pterocarpus angolensis DC and Their Cytotoxic Activities against Breast Cancer CellsPlants (Basel)January 19, 2024Zecarias W. Teclegeorgish, Ntebogeng S. Mokgalaka, Douglas Kemboi, Rui W. M. Krause, Xavier Siwe-Noundou, Getrude R. Nyemba, Candace Davison, Jo-Anne de la Mare, Vuyelwa J. TembuTriple-negative breast cancer cell line (HCC70) (estrogen receptor (ER)−, progesterone receptor (PR), (HER-2)−, (ATCC-CRL-2315)), hormone receptor-positive (ER+, PR +, HER-2) breast cancer cell line (MCF-7) (ATCC: HTB-22), and

(20) Chromatin Accessibility Landscape of Human Triple-negative Breast Cancer Cell Lines Reveals Variation by Patient Donor AncestryCancer Research CommunicationsOctober 5, 2023Alexandra R. Harris, Gatikrushna Panigrahi, Huaitian Liu, Vishal N. Koparde, Maeve Bailey-Whyte, Tiffany H. Dorsey, Clayton C. Yates, Stefan AmbsHTB-132; RRID: CVCL_0419), Hs578T (ATCC catalog no.: HTB-126; RRID: CVCL_0332), HCC70 (ATCC catalog no.: CRL-2315; RRID: CVCL_1270), BT549 (ATCC catalog no.: HTB-122; RRID: CVCL_1092), and HCC2157 (ATCC catalog no.:

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HCC70 from ATCC

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