E220 evolution Focused-ultrasonicator from Covaris LLC

Product Specs
ItemE220 evolution Focused-ultrasonicator
CompanyCovaris LLC
Price Get Pricing
Catalog Number500429
Dimensions(WxDxH) 24 x 30 x 19 inches (or 61 x 76 x 48 cm)
Quantity1
ApplicationsDNA/RNA/Chromatin Shearing:DNA/RNA/Total NA/Protein Extraction from FFPE:cfDNA Extraction from Plasma:DNA Extraction from Dried Blood Spots:Cell lysis: mammalian, bacterial, yeast:Tissue lysis and extraction
TypeFocused-ultrasonicator
Electrical RequirementsE100-120, 200-240 V~ 50-60Hz, 500 VAC
Regulatory StatusCE, ETL Mark (for Product Safety), WEEE
TemperatureAmbient Temperature: 19°C to 25°C (66°F to 77°C) Relative humidity: 30% to 70%
Volume15 to 130 µl
ComponentsmicroTUBE 8-strip (rack required)

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Covaris LLC

14 Gill St, Unit H

Woburn, Massachusetts 01801-1721

United States

Phone: +1 781-932-3959
Fax: +1 781-932-8705

Email: info@covaris.com

Company Profile

Website: www.covaris.com

(1) A distributive germline restricts the spread of new mutationsbioRxivFebruary 8, 2026Justin Scherer, Maa Ahema Gaisie, Sungjin Park, Brad Nelmsendosperm and pollen. DNA was then sheared with a Covaris E220 Evolution Sonicator (Covaris cat. no. 500429) to a final average size of ~350 bp (for the maize tassel maps in Fig. S5–S11) or 1000 bp (for all other

(2) Nanorate sequencing reveals the Arabidopsis somatic mutation landscapeProceedings of the National Academy of SciencesDecember 2, 2025Cullan A. Meyer, Brad Nelms, Robert J. Schmitz(Qiagen, 69106) following the manufacturer’s instructions. DNA was fragmented to 150 bp using a Covaris E220 Evolution Focused-ultrasonicator by the Georgia Genomic and Bioinformatics Core. 200 ng of fragmented DNA was size selected using in-house

(3) Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1bioRxivSeptember 22, 2025Alison A. Chomiak, Ashley K. Wiseman, Joel Hrit, Yanqing Liu, Stephanie Stransky, Simone Sidoli, Rochelle L. Tiedemann, Scott B. RothbartmilliTUBE (Covaris). Chromatin was sheared to a range of 300-600 base-pair fragments using a Covaris E220 evolution Focused ultrasonicator with the following parameters: Peak power (140.0), Duty Factor (5.0), Cycles/Burst (200), Duration (120

(4) Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trialNature MedicineAugust 14, 2025Kari L. Kendra, Shay L. Bellasea, Zeynep Eroglu, Siwen Hu-Lieskovan, Katie M. Campbell, William E. Carson, David A. Wada, Jose A. Plaza, Jeffrey A. Sosman, Gino K. In, et al.(30–50 μm) using a Covaris truXTRAC FFPE tNA Ultra Kit (SKU no. 520252) using either a Covaris M220 or E220 evolution Focused-ultrasonicator platform for the Adaptive Focused Acoustics (AFA)-enhanced paraffin emulsification and tissue rehydration

(5) Uncovering the molecular signature of feline diffuse iris melanoma through transcriptomic analysis of disease severitySci RepJuly 19, 2025D. Kayes, B. Blacklock, R. McGeachan, E. Scurrell, K. Donnelly, L. Murphy, A. Fawkes, R. Clark, A. Meynert, H. Becher, et al.07745 Jena, Germany). The LCM tissue was stored on ice and RNA extraction performed using the Covaris E220 Evolution Focused Ultrasonicator and truXTRAC® FFPE RNA microTUBE Kit—Column (Covaris Ltd, Woddington, Brighton, UK) according to a previously

(6) Cryogenic mouse tissue homogenization as an alternative to fresh-frozen biopsy use for genomics, transcriptomics, proteomics and metabolomicsSci RepJune 23, 2025Laimdota Zizmare, Ute Hofmann, Mohamed Ali Jarboui, Franziska Klose, Sabine Fraschka, Jakob Matthes, Marcel Krüger, Elke Schaeffeler, Matthias Schwab, Marius Ueffing, et al.methyl tert-butyl ether (MTBE), and ultrapure water with the focused ultrasonication technology (Covaris E220 evolution Focused Ultrasonicator, Woburn, MA, USA). After two-phase separation, the aqueous layer was evaporated to dryness. For NMR spectroscopy

(7) Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapyThe Journal of pathologyMarch 1, 2025Blacklock KLB, Donnelly K, Lu Y, Pozo JD, Glendinning L, Polton G, Selmic L, Tanis JB, Killick D, Parys M, et al.Covaris E220 Evolution Focused Ultrasonicator (Covaris Ltd, Woddington, Brighton, UK, Catalogue No. 500429) and the truXTRAC® FFPE total NA (Nucleic Acid) Kit – Column (Covaris, Catalogue No. 520220). Inhibitors

(8) DNA hypomethylation promotes UHRF1- and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin statesMolecular CellJanuary 16, 2025Yanqing Liu (刘延晴), Joel A. Hrit, Alison A. Chomiak, Stephanie Stransky, Jordan R. Hoffman, Rochelle L. Tiedemann, Ashley K. Wiseman, Leena S. Kariapper, Bradley M. Dickson, Evan J. Worden, et al.nuclei lysis buffer (50 mM Tris-Cl pH 8.0, 1 mM EDTA, and 1% SDS). Chromatin was sheared with a Covaris E220 Evolution Focused-Ultrasonicator for 12 minutes with default settings (Average incident power: 7 Walt; peak incident power: 140 Walt;

(9) A High-Throughput Droplet-based Method to Facilitate Microbial ConjugationBIO-PROTOCOLDecember 5, 2024Monica J. Chu, Jose A. Wippold, Rebecca Renberg, Margaret Hurley, Bryn L. Adams, Arum Hannumber: 50125590)Focused ultrasonicator for genome extractions (Covaris E220 Evolution, catalog number: 500429)Desiccator (Zoro, catalog number: G4655463)Spin coater (Laurell Technologies Corporation, model: H6-23)Photolithography

(10) A High-Throughput Droplet-based Method to Facilitate Microbial ConjugationBio ProtocDecember 5, 2024Monica J. Chu, Jose A. Wippold, Rebecca Renberg, Margaret Hurley, Bryn L. Adams, Arum Hannumber: 50125590)Focused ultrasonicator for genome extractions (Covaris E220 Evolution, catalog number: 500429)Desiccator (Zoro, catalog number: G4655463)Spin coater (Laurell Technologies Corporation, model: H6-23)Photolithography

(11) Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30The EMBO JournalNovember 29, 2024Pei-Ching Huang, Soogil Hong, Hasan F Alnaser, Eleni P Mimitou, Keun P Kim, Hajime Murakami, Scott Keeney4.0.3)",https://www.r-project.org/, Other,Other,Other E220 evolution Focused-ultrasonicator,Covaris,500429 FastPrep-24,MP Biomedicals,116004500 HiSeq2000,Illumina, Reagents and tools table

(12) Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expressionMolecular therapy. Nucleic acidsJune 11, 2024Dunn-Davies H, Dudnakova T, Nogara A, Rodor J, Thomas AC, Parish E, Gautier P, Meynert A, Ulitsky I, Madeddu P, et al.sonicator (Diagenode). Glutaraldehyde crosslinked (1%) lysates from ChIRP were sonicated on a Covaris E220 Evolution Focused-Ultrasonicator System using a water at a temperature range of 5°C-7°C and the following protocol: peak power 140 W,

(13) Low-Pass Genome Sequencing-Based Detection of Paternity: Validation in Clinical CytogeneticsGenes (Basel)June 27, 2023Keying Li, Yilin Zhao, Matthew Hoi Kin Chau, Ye Cao, Tak Yeung Leung, Yvonne K. Kwok, Kwong Wai Choy, Zirui Donglibrary construction [21]. For small-insert size libraries, genomic DNA from each sample was sheared with the Covaris E220 Evolution Focused-Ultrasonicator (Covaris, Inc., Woburn, MA, USA) into sizes of 300~500 bp and then subjected to library construction

(14) LKB1 controls inflammatory potential through CRTC2-dependent histone acetylationMolecular cellJune 1, 2023Compton SE, Kitchen-Goosen SM, DeCamp LM, Lau KH, Mabvakure B, Vos M, Williams KS, Wong KK, Shi X, Rothbart SB, et al.resuspended in shearing buffer (10 mM Tris-HCl, 1mM EDTA, 0.1% SDS). Chromatin was sheared with a Covaris E220 Evolution Focused-Ultrasonicator for 12 min. Chromatin was centrifuged at 10,000g 4°C for 5 min to pellet insoluble material, and supernatant

(15) Lung adenocarcinoma promotion by air pollutantsNatureApril 6, 2023William Hill, Emilia L. Lim, Clare E. Weeden, Claudia Lee, Marcellus Augustine, Kezhong Chen, Feng-Che Kuan, Fabio Marongiu, Edward J. Evans, David A. Moore, et al.measured using Qubit, and up to 3,000 ng of DNA was fragmented to approximately 1,500 bp using a Covaris E220 evolution focused-ultrasonicator following the manufacturer's standard protocol. SAGAsafe assays46 for five EGFR target variant alleles

(16) Exploiting a targeted resistome sequencing approach in assessing antimicrobial resistance in retail foodsEnvironmental MicrobiomeMarch 29, 2023Julie A. Shay, Laura S. E. Haniford, Ashley Cooper, Catherine D. Carrillo, Burton W. Blais, Calvin Ho-Fung Lauof 1 μg that was sheared to an average size of ~ 400 bp inside a microTUBE-15 (PN 520,145) using a E220 evolution focused-ultrasonicator (Covaris, Woburn, MA, United States). Unique dual indexing of libraries was achieved using the IDT-Illumina

(17) Genomic patterns of malignant peripheral nerve sheath tumor (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNACancer DiscovMarch 1, 2023Isidro Cortes-Ciriano, Christopher D. Steele, Katherine Piculell, Alyaa Al-Ibraheemi, Vanessa Eulo, Marilyn M. Bui, Aikaterini Chatzipli, Brendan C. Dickson, Dana C. Borcherding, Andrew Feber, et al.extraction from FFPE tissue samples was performed using the Covaris truXTRAC FFPE DNA kit with the E220 Evolution focused ultrasonicator system, and Prepito truXTRAC DNA FFPE kit with the Chemagic Prepito-D. Any excess paraffin was trimmed

(18) Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNACancer DiscoveryMarch 1, 2023Isidro Cortes-Ciriano, Christopher D. Steele, Katherine Piculell, Alyaa Al-Ibraheemi, Vanessa Eulo, Marilyn M. Bui, Aikaterini Chatzipli, Brendan C. Dickson, Dana C. Borcherding, Andrew Feber, et al.extraction from FFPE tissue samples was performed using the Covaris truXTRAC FFPE DNA kit with the E220 Evolution-focused ultrasonicator system, and Prepito truXTRAC DNA FFPE kit with the Chemagic Prepito-D. Any excess paraffin was trimmed

(19) The genetic mechanisms underlying the convergent evolution of pollination syndromes in the Neotropical radiation of Costus L.Frontiers in Plant ScienceSeptember 8, 2022Eugenio Valderrama et al.United States). When the majority of fragments for any given sample were longer than 350 bp, a Covaris E220 evolution Focused-ultrasonicator (Covaris, Woburn, MA, United States) was used following manufacturer’s protocols to obtain an average

(20) Predicting master transcription factors from pan-cancer expression dataScience advancesNovember 26, 2021Reddy J, Fonseca MAS, Corona RI, Nameki R, Segato Dezem F, Klein IA, Chang H, Chaves-Moreira D, Afeyan LK, Malta TM, et al.number 61311, Active Motif), and chromatin was sheared to 100- to 300-bp fragments using a Covaris E220 evolution focused ultrasonicator. ChIP libraries were constructed using the KAPA Hyper Library Preparation kit, quantified, and sequenced

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E220 evolution Focused-ultrasonicator from Covaris LLC

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E220 evolution Focused-ultrasonicator from Covaris LLC

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