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Protein Biochemistry
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CCG-1423
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CCG-1423
CCG-1423
CCG-1423 from Cayman Chemical
Be the first to write a review!
Citations:
(5)
Supplier Page
Supplier Page from
Cayman Chemical for
CCG-1423
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Description
A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription; inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
CCG-1423
Company
Cayman Chemical
Price
$197.00
Supplier Page
View Company Product Page
Catalog Number
10010350
Quantity
25 mg
Format
A crystalline solid
Molecular Weight
454.8
Purity
≥98%
Type
Inhibitors
Research Area
Cancer, Cell Migration & Metastasis, Cell Signaling, GTPases
Storage
-20
Formula
C18H13ClF6N2O3
Origin
USA
Specifications/Features
Ki, IC, EC, or working concentration
: IC50: 1 µM
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Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (5)
(1)
Actin Polymerization Status Regulates Tenocyte Homeostasis Through Myocardin‐Related Transcription Factor‐A
Cytoskeleton (Hoboken)
September 1, 2025
Valerie C. West, Kaelyn E. Owen, Kameron L. Inguito, Karl Matthew M. Ebron, Tori N. Reiner, Chloe E. Mirack, Christian H. Le, Rita de Cassia Marqueti, Steven Snipes, Rouhollah Mousavizadeh,
et al.
(#
10010630
;
Cayman Chemical Company
; Ann Arbor, MI, USA),
Cytochalasin D
(#
11330
;
Cayman
), and CCG1423 (#
10010350
;
Cayman
), respectively. These pharmacological agent concentrations had no adverse effect on cellular
(2)
Fibroblast senescence-associated extracellular matrix promotes heterogeneous lung niche
APL Bioengineering
June 5, 2024
Andrew M. Howes, Nova C. Dea, Deepraj Ghosh, Krishangi Krishna, Yihong Wang, Yanxi Li, Braxton Morrison, Kimani C. Toussaint, Michelle R. Dawson
media, DMSO, 1, 5, and 10 μM SB505124 (
Cayman Chemical
, No.
11793
) or
CCG-1423
(
Cayman Chemical
, No.
10010350
) every 48 h for 14 days. Samples were incubated in
MTT
solution for 3 h at 37 °C before
MTT
solvent
(3)
Rho/SRF Inhibitor Modulates Mitochondrial Functions
International journal of molecular sciences
September 29, 2022
Patyal P, Nguyen B, Zhang X, Azhar G, Ameer FS, Verma A, Crane J, Kc G, Che Y, Wei JY.
μL/well DMEM containing 10% FBS and treated with different concentrations of
CCG-1423
(
Cayman Chemicals
,
10010350
) for 24 h. Furthermore, 20 μL of an MTS reagent was added to each well three hours before the end of
(4)
Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition
American Journal of Respiratory and Critical Care Medicine
January 15, 2018
Diana Zabini et al.
following day cells were stimulated with basal media with or without 5% FCS and or 5 µMol/L CCG1423 (
10010350
;
Cayman Chemical
, Ann Arbor, Michigan; USA). Proliferation of huPASMCs and huPAECs was determined by
(5)
Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle
PloS one
January 1, 2017
Zhu B, Rippe C, Thi Hien T, Zeng J, Albinsson S, Stenkula KG, Uvelius B, Swärd K.
added and cells were harvested after another 48h. The effects of
CCG-1423
(
Cayman Chemical Company
,
10010350
),
CCG-100602
(
Cayman Chemical Company
,
10787
) and
CCG-203971
(
Tocris Bioscience
, 5277), which
inhibit
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CCG-1423 from Cayman Chemical
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$197.00
Product Specs
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