Sphingosine Kinase Inhibitor 2 from Cayman Chemical

Product Specs
ItemSphingosine Kinase Inhibitor 2
CompanyCayman Chemical
Price $44.00Supplier Page View Company Product Page
Catalog Number10009222
Research AreaCancer, Cell Signaling, Lipid Biochemistry, Sphingolipids
FormatA crystalline solid
Molecular Weight302.8
Purity≥95%
Storage-20
FormulaC15H11ClN2OS
OriginUSA
Quantity5 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 0.5 µM for non-ATP-competitive inhibition of human recombinant GST-SPHK 1
IC50: 0.9-4.6 µM for proliferation of several human cancer cell lines (T-24, MCF-7, NCI/ADR, and MCF-7/VP)

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Acid sphingomyelinase is a gatekeeper of placental labyrinthine architecture and functionDevelopmentOctober 1, 2025Isidora Rovic, Katherine Szelag, Han Li, Rosanne McQuaid, Sara Sugin, Que Wu, Natalia Theodora, John Sled, Andrea Jurisicovainstructions. To test the specificity of the kit, samples were incubated with a SPHK1 inhibitor (SKI-II) (10009222, Cayman Chemical), which produced no detectable signal. Quantitative real-time PCR RNA was extracted

(2) Thin Layer Chromatography Goes Ultrasmall to Assay Sphingosine Kinase Activation in Single Primary Leukemic CellsAnalytical ChemistryFebruary 11, 2025Ming Yao, Yuli Wang, Lucas Cornwell, Christopher E. Sims, Nancy L. Allbrittonmagnesium salts, # 14025092) were from Gibco (Grand Island, NY). K145 (#11691), FTY720 (#10006292), SKI2 (#10009222), PF-543 (#17034) were procured from Cayman Chemical Company (Ann Arbor, MI). Extracellular buffer (ECB)

(3) Amelioration of Fibrosis via S1P Inhibition Is Regulated by Inactivation of TGF-β and SPL Pathways in the Human CorneaInternational journal of molecular sciencesJune 14, 2024Nicholas SE, Basu SK, Mandal N, Karamichos D.Alabaster, AL, USA) in 4 mg/mL BSA in water at 37 °C inside a glass vessel. A stock solution of SPHK I2 (#10009222; Cayman Chemicals; Ann Arbor, MI, USA) was made at a concentration of 5 mM by dissolving the powder

(4) G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulationStem Cell Research & TherapyDecember 1, 2022Jaime M. Brozowski et al.after an overnight rest. Cells were treated with sphingosine kinase inhibitor 2 (SKI, Cayman Chemical, 10009222) at a final concentration of 5 µM or vehicle (DMSO). Fresh media changes occurred every third day using

(5) Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 ModulationJournal of VirologyMay 11, 2022Rachel S. Resop, Alberto Bosquenumber 10006292, CAS number 162359-56-0; DMS, number 62575, CAS number 119567-63-4; SKI II, number 10009222, CAS number 312636-16-1; ABC294640, number 10587, CAS number 915385-81-8). Cas9 nuclease/sgRNA gene knockout

(6) SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formationeLifeApril 23, 2021Sanders DW, Jumper CC, Ackerman PJ, Bracha D, Donlic A, Kim H, Kenney D, Castello-Serrano I, Suzuki S, Tamura T, et al.hydrochloride,Targetmol,T3724, "Chemical compound, drug",Scriptaid,ApexBio,A4106, "Chemical compound, drug",SKI II,Cayman,10009222, "Chemical compound, drug",Sorafenib,Cayman,10009644, "Chemical compound, drug",TAK-285,MCE,HY-15196, "Chemical

(7) Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 CellsCell reportsNovember 19, 2019Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM.(S1P),Cayman,62570 Rapamycin,Sigma,R8781 Fumonisin B1 (FB1),Cayman,62580 Sphingosine Kinase inhibitor (SKi)-II,Cayman,10009222 Latrunculin B1,Cayman,10010631 Fetal Bovine Serum (FBS),Sigma,F2442 Penicillin/Streptomycin,GIBCO,15140–122 Trypsin-EDT

(8) “Fix and assay”: separating in-cellulo sphingolipid reactions from analytical assay in time and space using an aldehyde-based fixativeThe AnalystJanuary 28, 2019Angela Proctor, Nancy L. Allbrittonethanol (#2701) was from Decon Labs (King of Prussia, PA). Sphingosine Kinase Inhibitor 2 (SKI II; #10009222) was procured from Cayman Chemical Company (Ann Arbor, MI). Sodium chloride (#S7653), potassium chloride

(9) Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteinsPloS oneJanuary 1, 2013Casson L, Howell L, Mathews LA, Ferrer M, Southall N, Guha R, Keller JM, Thomas C, Siskind LJ, Beverly LJ.treatments were done in triplicate. DL, PDMP (cat#10005276), AMP-DNM (cat#10010332) and SKi-II (cat#10009222) were obtained from Cayman Chemical (Ann Arbor, MI, USA) and ABT-263 (cat#CT-A263) was obtained from

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