SB 203580 from Cayman Chemical

Product Specs
ItemSB 203580
CompanyCayman Chemical
Price $308.00Supplier Page View Company Product Page
Catalog Number13067
Research AreaCell Biology, Cell Signaling, p38 MAPK Signaling
FormatA crystalline solid
Molecular Weight377.4
Purity≥98%
Storage-20
FormulaC21H16FN3OS
OriginCHN
TypeInhibitors
Quantity50 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 0.6 µM for p38 MAPK activity in heat-shocked HeLa cells and osmotically stressed PC12 cells.
IC50: 3-5 µM for phosphoinositide-dependent protein kinase 1 (PDK1)

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Cell confinement initiates a delayed but heritable loss of chromosomesCell RepMarch 24, 2026Steven H. Phan, Mai Wang, Kayla R. Snare, Jonah Kandell, Jeneille S. Deans, Panteleimon Rompolas, Guilherme P.F. Nader, Dennis E. Discherinhibitor Palbociclib (10μM) (Cayman Chemical 16273), p38 inhibitor SB 203580 (10μM) (Cayman Chemical 13067), pan-caspase inhibitor Z-VAD-FMK (20μM) (Enzo ALX-260-020), and centrosome inhibitor centrinone (0.125μM)

(2) S1P-S1PR1 signaling impairs CD8+ T cell metabolism and effector function in tumorsEMBO ReportsMarch 19, 2026Debashree Basak, Puspendu Ghosh, Anupam Gautam, Ishita Sarkar, Arpita Bhoumik, Soham Chowdhury, Shaun Mahanti, Anwesha Mandal, Rajeswari Chakraborty, Anwesha Kar, et al.Kit,Qiagen,12643 CRISPR/Cas9 knock-out kit,Takara Lenti X,632629 GSK2656157,Cayman,17372 SB203580,Cayman,13067 W146,Tocris,3602 ATP assay kit,Sigma,213-579-1 CHIP Kit,Cell Signaling Technology,9003 S1P,Sigma,S9666 Lonza

(3) Cell confinement initiates a delayed but heritable loss of chromosomesbioRxivFebruary 3, 2026Steven H. Phan, Mai Wang, Kayla R. Snare, Jonah Kandell, Jeneille S. Deans, Panteleimon Rompolas, Guilherme P.F. Nader, Dennis E. Discherinhibitor Palbociclib (10μM) (Cayman Chemical 16273), p38 inhibitor SB 203580 (10μM) (Cayman Chemical 13067), pan-caspase inhibitor Z-VAD-FMK (20μM) (Enzo ALX-260–020), and centrosome inhibitor centrinone (0.125μM)

(4) ILC3s sense gut microbiota through STING to initiate immune toleranceImmunityJuly 8, 2025Wenqing Zhou, Jordan Z. Zhou, Anees Ahmed, Myeong Joon Kim, JRI Live Cell Bank, Chun-Jun Guo, Gregory F. SonnenbergSML2726 Cytochalasin D,Selleckchem,Cat# S8184 CAPE,Cayman,Cat# 70750 MK-2206,Cayman,Cat# 11593 SB203580,Cayman,Cat# 13067 ACK lysis buffer,VWR,Cat# 12002-070 LyoVec,Invivogen,Cat# lyec-1 Pam3CSK4,Invivogen,Cat# tlrl-pms Poly

(5) Distinct cAMP Regulation in Scleroderma Lung and Skin Myofibroblasts Governs Their Dedifferentiation via p38α InhibitionFASEB JJune 30, 2025Jared D. Baas, John Varga, Carol Feghali-Bostwick, Marc Peters-Golden, Sean M. Fortierinhibitor SB203580 (20 μM) and p38α inhibitor VX‐702 (50 μM) were purchased from Cayman Chemicals (13067) and Selleckchem (HY‐10401), respectively. 2.2 Cell Culture Lung and skin fibroblasts from separate

(6) Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibitionAging (Albany NY)April 2, 2025Mehdi Razazian, Sheyda Bahiraii, Azmat Sohail, Markus Mandl, Isratul Jannat, Georg Beilhack, Ioana Alesutan, Jakob Voelklfisetin (stock in DMSO, HY-N0182, MedChemExpress), 10 μM of p38 MAPK inhibitor SB203580 (stock in DMSO, 13067, Cayman Chemical) [33] and 1 μM of p44/42 MAPK inhibitor LY3214996 (stock in DMSO, HY-101494, MedChemExpress)

(7) Podoplanin-positive cell-derived small extracellular vesicles contribute to cardiac amyloidosis after myocardial infarctionCell ReportsMarch 25, 2025Maria Cimini, Ulrich H.E. Hansmann, Carolina Gonzalez, Andrew D. Chesney, May M. Truongcao, Erhe Gao, Tao Wang, Rajika Roy, Elvira Forte, Vandana Mallaredy, et al.Angiotensin II,Sigma,A9525-1MG Recombinant SAA3,Biomatik,RPC20262 LPS,Sigma-Aldrich,L4391-1MG SB 203580,Cayman Chemical Company,13067 Intercept Blocking Reagent,LI-COR,927-70001 PKH26,Sigma-Aldrich,MINI26-1KT "DAPI (4′,6-diamidino-2-phenylindole

(8) Distinct cAMP regulation in scleroderma lung and skin myofibroblasts governs their dedifferentiation via p38α inhibitionbioRxivMarch 1, 2025Jared D. Baas, John Varga, Carol Feghali-Bostwick, Marc Peters-Golden, Sean M. Fortierinhibitor SB203580 (20 μM) and p38α inhibitor VX-702 (50 μM) were purchased from Cayman Chemicals (13067) and Selleckchem (HY-10401), respectively. Cell culture. Lung and skin fibroblasts from separate groups

(9) Regulation of voltage-gated sodium channels by TNF-α during herpes simplex virus latency establishmentJournal of NeuroVirologyDecember 1, 2024Qiaojuan Zhang, Shao-Chung Hsia, Miguel Martin-CaraballoTetrodotoxin (TXX, Sigma-Aldrich Cat.#554412), acyclovir (Sigma-Aldrich; Cat.#A4669), SB203580 (Cat.#13067) and SB202190 (Cat.#10010399) were purchased from Cayman Chemical. Data Analysis All electrophysiological

(10) p38 MAPK as a gatekeeper of reprogramming in mouse migratory primordial germ cellsFrontiers in Cell and Developmental BiologyJune 6, 2024Daiji Okamura, Aoi Kohara, Yuta Chigi, Tomoka Katayama, Jafar Sharif, Jun Wu, Yumi Ito-Matsuoka, Yasuhisa Matsuimedium supplemented with 10 µM SB239063 (Cayman Chemical, 19142) or 10 µM SB203580 (Cayman Chemical, 13067) or the solvent (Dimethyl Sulfoxide: DMSO, nacalai tesque, 09659-14) as a control, and P/S (1x). The

(11) TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathwaysThe Journal of experimental medicineDecember 4, 2023Chan W, Cao YM, Zhao X, Schrom EC, Jia D, Song J, Sibener LV, Dong S, Fernandes RA, Bradfield CJ, et al.(70970; Cayman Chemical), 10 μM of JNK Inhibitor VIII (15946; Cayman Chemical), 25 μM of SB 203580 (13067; Cayman Chemical), or 50 μM of Cyclosporin A (12088; Cayman Chemical) for 1 h at 37°C before imaging

(12) Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptorsScience SignalingOctober 3, 2023Stefan M. Lundgren, Briana L. Rocha-Gregg, Emel Akdoğan, Maya N. Mysore, Samantha Hayes, Sean R. Collinscatalog # 10460), NVP-BKM120 (Cayman Chemicals catalog # 11587), and SB203580 (Cayman Chemicals catalog # 13067). Human primary neutrophil isolation Ethical approval for the study of neutrophils from adult healthy

(13) Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial CellsCellsSeptember 30, 2023Teichmann E, Blessing E, Hinz B.purchased from Thermo Fisher Scientific (Schwerte, Germany). AM251 (#71670), AM630 (#10006974), SB203580 (#13067), SP600125 (#10010466), PD98059 (#10006726), BAY 11-7082 (#10010266), trichostatin A (TSA, #89730),

(14) Mechanism of cis-Nerolidol-Induced Bladder Carcinoma Cell DeathCancersFebruary 3, 2023Glumac M, Čikeš Čulić V, Marinović-Terzić I, Radan M.(72180). Small molecular inhibitors: xestospongin C (XSC; 64950), dandrolene-Na (DRN; 14326), SB203508 (13067), H-89 (10010556), KH7 (13243), and L755507 (18629) were obtained from Cayman Chemicals. Z-Vad (FMK001)

(15) High Salt Induces a Delayed Activation of Human NeutrophilsFrontiers in ImmunologyJune 3, 2022Ignacio Mazzitelli, Lucía Bleichmar, Claudia Melucci, Pehuén Pereyra Gerber, Agustina Toscanini, María Luján Cuestas, Fernando Erra Diaz, Jorge GeffnerS. cerevisiae (Z4250) were obtained from Sigma-Aldrich (St. Louis, MO, USA). SB202190 (10010399) and SB203580 (13067) were obtained from Cayman Chemical Company (Ann Arbor, MI, USA). Brefeldin A (BFA) (BD 555029) was

(16) O‑GlcNAcylation contributes to intermittent hypoxia‑associated vascular dysfunction via modulation of MAPKs but not CaMKII pathwaysMolecular medicine reportsNovember 1, 2021Guo X, Deng Y, Zhan L, Shang J, Liu H.(MEK inhibitor; cat. no. 1213) was from Tocris Bioscience and SB203580 (p38 MAPK inhibitor; cat. no. 13067) from Cayman Chemical Company. Ach (cat. no. A2661), phenylephrine (PE; cat. no. P6126), the NOS blocker

(17) Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumorsImmunityJuly 13, 2021Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, et al.10634-MG Brefeldin A,BioLegend,Cat# 420601 α-Tocopherol,Cayman Chemical,Cat# 30776 SB203580,Cayman Chemical,Cat# 13067 Other resources,, 70 μM cell strainers,Corning Falcon,Cat# 352350 Single Cell 3′ Library & Gel Bead

(18) Inhibition of aberrant tissue remodelling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cuesNature Biomedical EngineeringJune 3, 2021Sing Wan Wan Wong, Chandramohan R. Tamatam, Ik Sung Cho, Peter T. Toth, Raymond Bargi, Patrick Belvitch, James C. Lee, Jalees Rehman, Sekhar P. Reddy, Jae-Won Shincells were stimulated with TNF-α or IL-1β for 3 days, and purchased from Cayman Chemical: SB203580 (13067, 10 μM) to inhibit p38 MAPK, SP600125 (10010466, 20 μM) to inhibit JNK, U0126 (70970, 5 μM) to inhibit

(19) The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signalingOncotargetOctober 6, 2020Pal P, Hales K, Hales DB.(D6922-02) was purchased from Omega Bio-Tek. SB203580 p38 MAPK inhibitor was purchased from Cayman Chemical (13067). MATERIALS AND METHODS Materials Cell culture and treatments BG1 cells were obtained from the laboratory

(20) Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancerJournal of ovarian researchMay 25, 2019Pal P, Hales K, Petrik J, Hales DB.(SH30604.02); 2-methoxyestradiol from Sigma-Aldrich (M6383); SB203580 p38-MAPK inhibitor from Cayman chemical (13067); DHA (3687) from Tocris Biosciences; 100x HALT protease and phosphatase inhibitor cocktail from ThermoFisher

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SB 203580 from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

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Reviews

SB 203580 from Cayman Chemical

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