FK-866 from Cayman Chemical

Product Specs
ItemFK-866
CompanyCayman Chemical
Price $561.00Supplier Page View Company Product Page
Catalog Number13287
Research AreaApoptosis, Cancer, Cell Death
FormatA crystalline solid
Molecular Weight391.5
Purity≥98%
Storage-20
FormulaC24H29N3O2
OriginUSA
TypeInhibitors
Quantity50 mg

Specifications/Features

Ki, IC, EC, or working concentration: Ki: 0.4 nM
IC50: ~1 nM

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Redox index and capacity analysis (RICA) reveals NAD biology changes in T cell responses in vitro and ex vivoJ ImmunolApril 15, 2026Alicia M. Bostwick-Galaviz, Edward J. UsherwoodμL TCM + 25 IU/mL rhIL-2 +/− 1 mM NMN (MedChem Express HY-F004) and +/− 10 nM FK866 (Cayman Chemical 13287) and incubated at 37 °C for 5 hours. Cells were washed with cold RICA buffer, Fc blocked, and stained

(2) Intracellular accumulation of free cholesterol in macrophages triggers a PARP1 response to DNA damage and PARP1 impairs lipopolysaccharide-induced inflammatory responsePLoS OneMarch 5, 2025Kenneth K.Y. Ting, Hisham M. Ibrahim, Nitya Gulati, Yufeng Wang, Jonathan V. Rocheleau, Myron I. Cybulskyspectrophotometer. The consumption rate of NAD + was measured by adding FK-866 (100 µ M) (Cayman Chemical, Cat#13287) to cells every 15 minutes for up to 1 h. The consumption rate of NAD + by PARP1 was measured by treating

(3) NAD(+) precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injuryNature metabolismMarch 1, 2023Doke T, Mukherjee S, Mukhi D, Dhillon P, Abedini A, Davis JG, Chellappa K, Chen B, Baur JA, Susztak K.treatment. Renal tubule cells were incubated with FK866 (100nM, NAMPT inhibitor, Cayman Chemical, #13287) to delete NAD+ for indicated time. Mitochondria ROS and membrane potential were assessed by staining

(4) NAD(+) metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunityProceedings of the National Academy of Sciences of the United States of AmericaAugust 30, 2022Meyer T, Shimon D, Youssef S, Yankovitz G, Tessler A, Chernobylsky T, Gaoni-Yogev A, Perelroizen R, Budick-Harmelin N, Steinman L, et al.instructions. In some experiments, cells were pretreated for 2 h with FK866 (Cayman Chemical Company, #13287), 78C (EMD Millipore, #5.38763.0001), NFAT activation inhibitor III (INCA-6; Cayman Chemical Company

(5) In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19Frontiers in Cardiovascular MedicineMarch 24, 2022Takaharu Asano, Sarvesh Chelvanambi, Julius L. Decano, Mary C. Whelan, Elena Aikawa, Masanori AikawaAcetylcysteine (Cayman, 20261), Amifostine (Cayman 14398), Bortezomib (Ayman 10008822), FK-866 (Cayman 13287), Gemcitabine (Cayman 11690), Idarubicin (Cayman 14176), NVP-AUY922 (Cayman 10012698), NVP-BEZ235 (Cayman

(6) Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammationiScienceNovember 19, 2021Poli V, Pui-Yan Ma V, Di Gioia M, Broggi A, Benamar M, Chen Q, Mazitschek R, Haggarty SJ, Chatila TA, Karp JM, et al.S8502 Belinostat,Sellckchem,Cat# S1085 Panobinostat,Sellckchem,Cat# S1030 FK866,Cayman Chemical,Cat# 13287 Apabetalone,Sellckchem,Cat# S7295 Deferoxamine,Cayman Chemical,Cat# 14595 Batimastat,Cayman Chemical,Cat#

(7) Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein responseiScienceOctober 22, 2021Yi-Fan Lin, Jessica Sam, Todd Evans(MS-222),Syndel,Tricaine-S SU5402,Selleckchem,S7667 Nicotinamide (NAM),Sigma,N0636 Sirtinol,Sigma,566321 FK-866,Cayman Chemical,13287 Doxycycline,Sigma,D9891 Cas9 protein,PNA Bio,CP01-200 T7 nuclease,New England Biolabs,M0302L Pfusion

(8) Flow Cytometry Analysis of Free Intracellular NAD⁺Using a Targeted BiosensorCurrent Protocols in CytometryApril 1, 2019Jared M. Eller, Melissa L. Stewart, Alexandria J. Slepian, Sheila Markwardt, Jack Wiedrick, Michael S. Cohen, Richard H. Goodman, Xiaolu A. CambronneBicarbonate, +L-Glutamine (Thermo Fisher Cat# 31985–070); store at 4°C. FK866 (Cayman Chemical, cat# 13287); store stock at 50 mM at −20°C: Serially dilute fresh to final 10 nM concentration before use on cells. Dimethyl

(9) Quantitative Analysis of NAD Synthesis-Breakdown FluxesCell metabolismMay 1, 2018Liu L, Su X, Quinn WJ 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, et al.following drugs for perturbing NAD synthesis or consumption were purchased: FK866 (Cayman Chemical, 13287, 100nM), olaparib (10 μM), sirtinol (Sigma, S7942, 20 μM), EX527 (Sigma, E7034, 10 μM), zeocin (Invitrogen,

(10) CD38-NAD⁺Axis Regulates Immunotherapeutic Anti-Tumor T Cell ResponseCell metabolismJanuary 9, 2018Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, et al.and Recombinant Proteins","Chemicals, Peptides, and Recombinant Proteins" FK866,Cayman Chemical,Cat# 13287 Ex527,Cayman Chemical,Cat# 10009798 Etomoxir,Cayman Chemical,Cat# 11969 AKTi,Cayman Chemical,Cat#

(11) Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screensChemistry & biologyNovember 21, 2013Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, et al.Specs, and Chembridge. STF-118804 was synthesized at ChemDiv. FK866 was acquired from Cayman Chemicals (13287). Gallotannin (16201) and nicotinic acid (72309) were purchased from Sigma Aldrich. Compounds were dissolved

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FK-866 from Cayman Chemical

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Specifications/Features

Cayman Chemical

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FK-866 from Cayman Chemical

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