SB-431542 (hydrate) from Cayman Chemical

Product Specs
ItemSB-431542 (hydrate)
CompanyCayman Chemical
Price $394.00Supplier Page View Company Product Page
Catalog Number13031
Research AreaALK (Activin-like Kinase) Signaling, Cancer, Cell Biology, Cell Signaling, Differentiation, Stem Cell Research
FormatA crystalline solid
Molecular Weight384.4
Purity≥98%
Storage-20
FormulaC22H16N4O3 • XH2O
OriginCHN
TypeInhibitors
Quantity25 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 94 nM for TGF-beta1 receptor ALK5
IC50: 140 nM for ALK4

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Phenotypic Screening of human iPSC-Derived Neurons identifies Thienopyridone as a Neuritogenic Small MoleculeiScienceMay 15, 2026Keiko Imamura, Hiroshi Yukikate, Takeshi Hioki, Aya Okusa, Keisuke Shibata, Iñigo Narvaiza, Akira Kaieda, Bunnai Saito, Nozomu Sakai, Dang Ngoc Anh Suong, et al.,Thermo Fisher Scientific,Cat#25030-081 2-mercaptoethanol,Sigma-Aldrich,Cat#21985-023 dorsomorphin,Sigma-Aldrich,Cat#P5499 SB431542,Cayman Chemical,Cat#13031 Matrigel,Corning,Cat#354230 Neurobasal Medium,Thermo Fisher Scientific,Cat#21103-049 B27 without

(2) Protocol for measuring lipid membrane fluidity in human iPSC-derived neural cellsSTAR ProtocMarch 18, 2026Satoshi Morita, Takayuki Kondo, Haruhisa InoueScientific,450–03 Penicillin-Streptomycin,Thermo Fisher Scientific,15140122 SB431542,Cayman Chemical,13031 StemFit AK02N,Ajinomoto,RCAK02N Triton X-100,Nacalai Tesque,35501–15 TrypLE™ Select Enzyme,Thermo Fisher Scientific

(3) Transforming growth factor-β1 downregulates tryptophanyl-tRNA synthetase expression in human lung fibroblastsAdvances in Medical SciencesMarch 1, 2026Aaron K. McDowell-Sanchez, Konstantin TsoyiSB431542, wortmannin, LY3214996, SP600125, and SB202190 were obtained from Cayman Chemical (Cat#: 19959, 13031, 10010591, 27936, 10010466, and 10010399, respectively; Ann Arbor, MI, USA). All other reagents were

(4) Protocol for stable isotopic tracing to assess cellular lipogenic activity in induced neural stem cellsSTAR ProtocolsMarch 1, 2026Rosana-Bristena Ionescu, Julie A. Reisz, Monika Dzieciatkowska, Daniel Stephenson, Alexandra M. Nicaise, Pranathi Prasad, Cory M. Willis, Marta Suarez Cubero, Luca Peruzzotti-Jametti, Frank Edenhofer, et al.Guidance Systems,Cat#SM13 hLIF,Cell Signaling Technology,Cat#62226S SB-431542,Cayman Chemicals,Cat#13031 Y-27632,Miltenyi Biotec,Cat#130-103-933 Growth Factor Reduced Matrigel Matrix,Corning,Cat#354230 Accutase,Thermo Fisher Scientific

(5) Brain organoid models of SZT2-related disease reveal an overproduction of outer radial glial cells through mTORC1 activationScientific ReportsJanuary 14, 2026Emi Sato, Yuji Nakamura, Masanori Fujimoto, Issei S. Shimada, Toshihiko Iwaki, Daisuke Ieda, Yutaka Negishi, Ayako Hattori, Yoichi Kato, Shinji SaitohCat#137-06862), 100 nM LDN-193,189 (Cayman Chemical, Cat#19396), 10 µM SB-431,542 (Cayman Chemical, Cat#13031), and 2 µM XAV939 (Cayman Chemical, Cat#13596). The ‘organoid 1 media’ consisted of 50% DMEM/F12 and

(6) Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease modelsCell ReportsDecember 23, 2025Wardiya Afshar-Saber, Juan F. Ruiz, Isabel Gisser, Ziqin Yang, Leena Mehendale, Nicole A. Teaney, Rachel Hobson, Madison R. Glass, Truc T. Pham, Elizabeth Bainbridge, et al.treatment of 2.5 μM XAV939 (Cayman Chemical Company, 13596) and 10 μM SB431542 (Cayman Chemical Company, 13031). Right after patterning, cells were dissociated using Accutase Cell Dissociation Solution (Sigma-Aldrich,

(7) Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitisNat CommunDecember 10, 2025Babajide A. Ojo, Ying Zhu, Lyong Heo, Sejal R. Fox, Yanli Qiao, Amanda Waddell, Maria E. Moreno-Fernandez, Marielle Gibson, Tracy Tran, Ashley L. Dunn, et al.(STEMCELL Technologies, #06010) containing 10 µM TGF-beta receptor inhibitor, SB431542 (Cayman Chemical, #13031), 10 µM ROCK inhibitor, Y27632 (STEMCELL Technologies, #72304), and 50 µg/mL Normocin. Crypts were placed

(8) Generation and transcriptome profiling of bonobo induced pluripotent stem cells using stealth RNA vectors: a tripartite comparative study with humans and chimpanzeesBMC GenomicsDecember 5, 2025Yusuke Hamazaki, Hiroto Akuta, Hikaru Suzuki, Hideyuki Tanabe, Tsubasa Suzuki, Kouki Inoue, Kenji Ichiyanagi, Takuya Imamura, Masanori ImamuraThe next day, 2 μM dorsomorphin (11967; Cayman Chemical Company, Ann Arbor, MI, USA), 10 μM SB431542 (13031; Cayman Chemical Company), 1 ng/ml Stembeads FGF2 (SB500; StemCultures, Rensselaer, NY, USA), and 1

(9) Trophoblast stem cell derivation from naive and primed hPSC enables ELF5 functional analysisStem Cell ReportsOctober 14, 2025Joonas Sokka, Ella Lapinsuo, Jouni Kvist, Sami Jalil, Masahito Yoshihara, Jere Weltner, Fredrik Lanner, Juha Kere, Diego Balboa, Timo Otonkoski, et al.CHIR99021 [Stemgent, 04-0004-10], 0.5 μM A83-01 [Sigma, SML0788-5MG], 1 μM SB431542 [Cayman Chemicals, 13031], 0.8 mM sodium butyrate [Sigma, B5887-1G], and 5 μM Y-27632 [Selleckchem, S1049]). The medium was changed

(10) Dairy byproducts as sustainable alternatives to FCS in 2D and 3D skeletal muscle cell culturesBioresources and BioprocessingSeptember 22, 2025Tobias Horst Baldeweg, Philipp Hubel, Johannes Günther, Fabian Ostertag, Svenja Nellinger, Simon Heine, Petra Juliane Klugermedium. Differentiation medium consisted of DMEM/F12 (L0092, Biowest) with 1% ITS and 10 µM SB431542 (13031, Cayman Chemical, Ann Arbor, Michigan, USA). Medium was exchanged after 72 h. Cells were fixed or harvested

(11) Mitochondrial dysfunction mediated by ER-calcium dysregulation in neurons derived from Alzheimer's disease patientsActa Neuropathol CommunJuly 29, 2025Sarah Mustaly-Kalimi, Wacey Gallegos, Daniel Steinbrenner, Smriti Gupta, Aiden J. Houcek, David A. Bennett, Robert A. Marr, Daniel A. Peterson, Israel Sekler, Grace E. StutzmannStem Cell: 252917-06-9), forskolin (5µM, Stem Cell: 72112), and SB-431,542 (10µM, Cayman Chemical Company: 13031) to induce neuronal differentiation. Puromycin was added to neuroinduction media to select for neuronal

(12) Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer's diseaseTransl NeurodegenerJuly 29, 2025Abdolhossein Zare, Saeede Salehi, Jakob M. Bader, Anna-Lena Wiessler, Manuela Prokesch, Vincent Albrecht, Carmen Villmann, Matthias Mann, Michael Briese, Michael Sendtnerneuronal induction, iPSCs were maintained in mTeSR Plus medium supplemented with 10 µmol/L SB431542 (13031, Cayman Chemical Co., Ann Arbor, MI), 1 µmol/L dorsomorphin homolog 1 (4126, R&D Systems, Minneapolis,

(13) Serine synthesis pathway regulates cardiac differentiation from human pluripotent stem cellsiScienceJuly 18, 2025Tomohiko C. Umei, Shugo Tohyama, Yuika Morita-Umei, Manami Katoh, Seitaro Nomura, Kotaro Haga, Takako Hishiki, Tomomi Matsuura, Hidenori Tani, Yusuke Soma, et al.341-01622 D-Glucose-13C6,ISOTEC,Cat# 389374 EmbryoMax® Nucleosides (100X),Sigma-Aldrich,Cat# ES-008-D SB431542,Cayman Chemical,Cat# 13031 PD173074,FUJIFILM Wako Pure Chemical,Cat# 160-26831 N-acetyl-L-cysteine,Sigma-Aldrich,Cat# A7250 Isoproterenol,Sigma-Aldrich,Cat#

(14) Robust Production of Parvalbumin Interneurons and Fast-Spiking Neurons from Human Medial Ganglionic Eminence OrganoidsbioRxivJuly 4, 2025Maria C. Varela, Miranda P. Walker, Jeyoon Bok, Emmanuel L. Crespo, Tyler Thenstedt, Leah Goldstein, Andrew M. Tidball, Jun Z. Li, Yukun Yuan, Lori L. Isom, et al.μM DMH1 (Tocris, 4126), 2 μM XAV939 (Cayman Chemical, 13596), and 10 μM SB431542 (Cayman Chemical, 13031) (2 mL of media per well). On DIV 4, media was removed, and the monolayer was incubated for 1 min with

(15) An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrierCell Stem CellJuly 3, 2025Deepti Lall, Michael J. Workman, Samuel Sances, Briana N. Ondatje, Shaughn Bell, George Lawless, Amanda Woodbury, Dylan West, Amanda Meyer, Andrea Matlock, et al.,Thermo Fisher Scientific,Cat#15240062 LDN193189,Cayman Chemicals,Cat#17502048 SB431542,Cayman Chemicals,Cat#13031 CHIR99021,Cayman Chemicals,Cat#13122 All-Trans Retinoic Acid (ATRA),Stemgent,Cat#04-0021 Smoothened

(16) Polyunsaturated fatty acids in lipid membranes regulate human neuronal function and amyloid-β productioniScienceJune 20, 2025Satoshi Morita, Takayuki Kondo, Hisanori Tokuda, Yoshihisa Kaneda, Takayuki Izumo, Yoshihiro Nakao, Haruhisa InoueFisher Scientific,Cat# 450-10 NT-3,Thermo Fisher Scientific,Cat# 450-03 SB431542,Cayman Chemical,Cat# 13031 Dorsomorphin,Merck,Cat# P5499 Y-27632,Nacalai Tesque,Cat# 18188-04 "cOmplete™ mini, EDTA-free Protease

(17) KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoidsNeuronApril 16, 2025Joshua E. Berlind, Jesse D. Lai, Cecilia Lie, Jokabeth Vicente, Kelsey Lam, Sheron Guo, Jonathan Chang, Violeta Yu, Justin K. Ichida,Stem Cell Technologies,Cat# 85851 Dorsomorphin,Cayman Chemicals,Cat# 11967 SB-431542,Cayman Chemicals,Cat# 13031 DMEM/F12,Gibco,Cat# 11320033 Knockout Serum,Gibco,Cat# 10828028 Non-essential amino acids,Gibco,Cat#

(18) A Novel Phosphorylated Tau Conformer Implicated in the Tauopathy Pathogenesis of Human NeuronsBiomoleculesApril 15, 2025Nahid Tofigh, Sadaf Agahi, Gholamhossein Riazi, Mahboobeh Ghalamkar Moazzam, Koorosh Shahpasandmolecules at final concentrations: 3 μM CHIR99021 (Stemgent, USA, S04000410), 3 μM SB4315242 (Cayman, USA, 13031), 5 μM dorsomorphin (Stemgent, 040024), and 0.5 μM SAG (Calbiochem, USA, 566660). Medium changes were

(19) Nanosensor-based imaging of realtime dopamine release in neurons derived from iPSCs of patients with Parkinson's diseaseMaterials Today BioApril 1, 2025Nayeon Lee, Dakyeon Lee, Jae Hyeok Lee, Bo Seok Lee, Sungjee Kim, Jae Ho Kim, Sanghwa Jeonginhibitors and WNT activator. Dual SMAD inhibitors, 0.2 μM LDN193189 (04–0074, Stemgent) and 10 μM SB431542 (13031, Cayman) were added from day 1–10 and 1 to 8, respectively. From days 2–10, we added 100 ng/ml Sonic

(20) High-throughput transcriptome analysis reveals a developmental increase in Acvr1c which mediates epigenetic repression of the gene encoding the pubertal brake, Makorin ring finger protein 3NAR Molecular MedicineMarch 29, 2025Dor Shalev, Gil Golan, Lilach Pnueli, Anat Kahan, Yael Mandel-Gutfreund, Philippa MelamednM, SRP6057 Sigma), Activin B (7.7 nM [100 ng/ml], 8260-AB-010/CF, R&D Systems), or SB431542 (10 μM, #13031 Cayman), doses based on published studies [30–32]. Stable transfections were carried out in cells at

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SB-431542 (hydrate) from Cayman Chemical

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Specifications/Features

Cayman Chemical

Citations (85)

Reviews

SB-431542 (hydrate) from Cayman Chemical

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