JZL 184 from Cayman Chemical

Product Specs
ItemJZL 184
CompanyCayman Chemical
Price $658.00Supplier Page View Company Product Page
Catalog Number13158
Research AreaCannabinoid Research, Endocannabinoids, Neuroscience, Pain Research
FormatA crystalline solid
Molecular Weight520.5
Purity≥97%
Storage-20
FormulaC27H24N2O9
OriginUSA
TypeInhibitors
Quantity100 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 8 nM for MAGL
IC50: 4 µM for FAAH

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Palmitic acid induces UCP1-independent mitochondrial depolarization specifically in brown adipose tissueJournal of Biological ChemistryMarch 1, 2026Yuto Ishikawa, Isshin Shiiba, Eisho Kozakura, Haruto Yabu, Shun Hirose, Hijiri Oshio, Ken-ichi Yamada, Yuko Okamatsu-Ogura, Ryoko Inatome, Shigeru Yanagi(S0163) were purchased from Tokyo Chemical Industries. SR 59230A (21407), H-89 (10010556), JZL184 (13158), CAY10499 (10007875), perhexiline (16982), sotrastaurin (16726), α-linolenic acid (90210), arachidonic

(2) Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptationCell ReportsSeptember 12, 2023Veronika Kondev, Mustafa Najeed, Farhana Yasmin, Amanda Morgan, Niharika Loomba, Keenan Johnson, Danielle N. Adank, Ao Dong, Eric Delpire, Yulong Li, et al.proteins" Rimonabant,Cayman Chemicals,9000484 DO34,Glixx Laboraties,GLXC-09757 JZL184,Cayman Chemicals,13158 "CP-55,940",Cayman Chemicals,13608 CNO-HCl,Cayman Chemical,25780 Experimental models: Organisms/strains,Experimental models

(3) JZL184 increases anxiety-like behavior and does not reduce alcohol consumption in female rats after repeated mild traumatic brain injurybioRxivJune 2, 2023Alejandra Jacotte-Simancas, Patricia Molina, Nicholas Gilpinneurobehavioral outcomes, and attenuated motivation for alcohol drinking in male rats18,35,37. JZL184 (Item 13158, Cayman Chemical, Ann Arbor, MI,) or vehicle was injected intraperitoneally (i.p.) 30 minutes after

(4) Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neuronsCell reportsMarch 28, 2023Steiger LJ, Tsintsadze T, Mattheisen GB, Smith SM.08637 FM1-43,Invitrogen,Cat# T3163 Matrigel Basement Membrane Matrix,Corning,Cat# 354234 JZL184,Cayman Chem,Cat# 13158 ,, Experimental models: Organisms/strains,Experimental models: Organisms/strains,Experimental models:

(5) Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmissionCell ReportsMarch 1, 2023Nathan D. Winters, Veronika Kondev, Niharika Loomba, Eric Delpire, Brad A. Grueter, Sachin Patel,Cayman Chemical,Cat. #: 9000484 DO34,Glixx Laboratories,Cat. #: GLXC-09757 JZL184,Cayman Chemical,Cat. #: 13158 NESS-0327,Cayman Chemical,Cat. #: 10004184 Experimental models: Organisms/strains,Experimental models:

(6) In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activityNeuronAugust 1, 2021Jordan S. Farrell et al.peptides, and recombinant proteins" Celecoxib,Cayman Chemicals,Cat#10008672 JZL184,Cayman Chemicals,Cat#13158 ONO8130,Cayman Chemicals,Cat#19118 URB597,Cayman Chemicals,Cat#10046 LEI401,MedChemExpress,Cat#HY-131181 DO34,Aobious,Cat#AOB8060 Experimental models

(7) Endocannabinoids Inhibit the Induction of Virulence in Enteric PathogensCellOctober 1, 2020Melissa Ellermann et al.mix 10mM,Invitrogen,Cat# 18–427-088 AM630,Cayman Chemical,Cat# 10006974 JZL184,Cayman Chemical,Cat# 13158 Chloroform,IBM Scientific,Cat# 67–66-3 Bovine Serum Albumin,Sigma-Aldrich,Cat# A2153 Bio-Safe Coomassie Stain

(8) Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical StrengtheningNeuronMarch 1, 2020David J. Marcus et al.Proteins" Rimonabant,Cayman Chemical,9000484 DO34,Glixx Laboratories,GLXC-09757 JZL184,Cayman Chemical,13158 "CP55,940",Cayman Chemical,13608 PF3845,Cayman Chemical,13279 NESS0327,Cayman Chemical,10004184 CNO-HCl,Cayman Chemical

(9) The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum ParasitesCell chemical biologyFebruary 20, 2020Yoo E, Schulze CJ, Stokes BH, Onguka O, Yeo T, Mok S, Gnädig NF, Zhou Y, Kurita K, Foe IT, et al.2013)",N/A ML348,"(Adibekian et al., 2014)",N/A ML349,"(Adibekian et al., 2014)",N/A JZL 184,Cayman Chemical,Cat# 13158 JW651,Sigma-Aldrich,Cat# SML0990 MJN110,"(Niphakis et al., 2013)",N/A KML29,"(Chang et al., 2012)",N/A Trialzole

(10) Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injuryJournal of NeurophysiologyFebruary 1, 2020Elizabeth A. Fucich, Zachary F. Stielper, Heather L. Cancienne, Scott Edwards, Nicholas W. Gilpin, Patricia E. Molina, Jason W. Middletonin our previous studies (Fucich et al. 2019; Katz et al. 2015; Mayeux et al. 2017) JZL184 (item no. 13158; Cayman Chemical, Ann Arbor, MI) was used to selectively inhibit MAGL, the enzyme that degrades 2-AG.

(11) Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's diseaseTheranosticsJanuary 1, 2020Syal C, Kosaraju J, Hamilton L, Aumont A, Chu A, Sarma SN, Thomas J, Seegobin M, Dilworth FJ, He L, et al.as described below. Drug treatment in cultured SVZ NPCs Mgll inhibitor, JZL 184 (Cayman Chemical, 13158-5) and eCBR1 and eCBR2 agonists, Arachidonyl-2'-chloroethylamide (ACEA) (Cayman Chemical, 91054) and

(12) A Novel Role for the Endocannabinoid System in Ameliorating Motivation for Alcohol Drinking and Negative Behavioral Affect after Traumatic Brain Injury in RatsJournal of NeurotraumaJune 1, 2019Elizabeth A. Fucich, Jacques P. Mayeux, M. Adrienne McGinn, Nicholas W. Gilpin, Scott Edwards, Patricia E. Molinaad libitum food and water prior to resuming operant drinking post-TBI. MAGL inhibition JZL184 (Item #13158, Cayman Chemical, Ann Arbor, MI) was used to selectively inhibit MAGL, the enzyme that degrades 2-AG. Systemic

(13) The Protective Effect of EET on Renal I/R through NLRP3 and PyroptosisInternational Journal of Nephrology and Kidney FailureJanuary 1, 2019Zhu Y, Ding A, Yang H, Chen BH, Guo JLanalysis. Reagent The 14,15-EET analogue was purchased from Cayman Chemical Company (Item:10009286). NLRP3 (#13158), cleaved-caspase-1 (#89332), pro-IL-1β (#12703), IL-1β (#12703), NF-κB p65 (#8242), GAPDH (#2118) and

(14) Correlating chemical sensitivity and basal gene expression reveals mechanism of actionNature chemical biologyFebruary 1, 2016Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, et al.induction of EMT as described previously22. Small molecules for validation assays JZL184 (Cat. no. 13158; ≥97% purity) was purchased from Cayman Chemical. ML239 (SML0442; ≥98%), NSC23766 (SML0952; ≥97%), CP-100356

(15) Measurement of LipolysisMethods in EnzymologyMay 7, 2014Martina Schweiger, Thomas O. Eichmann, Ulrike Taschler, Robert Zimmermann, Rudolf Zechner, Achim Lasshydrolase activity, the MGL-specific inhibitor JZL 184 (Cayman Chemicals, Michigan, United States, cat. no. 13158) can be used (Long, Nomura, & Cravatt, 2009). Stock solution (20 mM) of respective inhibitors is prepared

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JZL 184 from Cayman Chemical

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Specifications/Features

Cayman Chemical

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JZL 184 from Cayman Chemical

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