MG132 from Cayman Chemical

Product Specs
ItemMG132
CompanyCayman Chemical
Price $97.00Supplier Page View Company Product Page
Catalog Number10012628
Research AreaApoptosis, Cancer, Cell Biology, Cell Death, Cell Signaling, Epigenetics, Transcription, & Translation, NF-κB, NF-κB Signaling, Proteolysis, Transcription Factors, Ubiquitin/Proteasome System
FormatA crystalline solid
Molecular Weight475.6
Purity≥98%
Storage-20
FormulaC26H41N3O5
OriginCHN
TypeInhibitors
Quantity10 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 42 nM for cell growth in B16 cells
IC50: 77 nM for cell growth in IPC227F cells

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosisActa NeuropatholMarch 16, 2026Cassandra Barone, Rihua Wang, Sarah Cooke, Hang Pong Ng, Rodolfo S. Ferreira, Helen C. Miranda, Xin Qimaintained in day 25+ media. Cell media was changed every other day. MG-132 (1 µM) (Cayman Chemical: #10012628) treatment was completed 24 h before cell collection (day 26). All iPSC-MNs were collected by day 27. Lentiviral

(2) Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor GrowthMolecular Cancer TherapeuticsFebruary 4, 2026Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez, Andrew Massey, Vivek K. Kashyap, Neeraj Chauhan, Emmanuel Anning, Manish K. Tripathi, Dae J. Kim, et al.file. Reagents BMH-21 (Cat. No. S7718) was obtained from Selleck Chemicals, and (S)-MG132 (Item No. 10012628) was obtained from Cayman Chemical (42). Cell culture Capan-2, AsPC-1, MIA PaCa-2, HPAF-II, BxPC-3,

(3) Regulation of pexophagy by a novel TBK1-MARCHF7-PXMP4-NBR1 axis in PEX1-depleted HeLa cellsAutophagyFebruary 1, 2026Yong Hwan Kim, Joon Bum Kim, Ji-Eun Bae, Na Yeon Park, Seong Hyun Kim, Jae-Young Um, Dong-Seok Lee, Kyu Sun Lee, Peter K. Kim, Doo Sin Jo, et al.Sigma-Aldrich. GSK8612 (HY-111941) and MRT67307 (HY-13018) were purchased from MedChemExpress. MG132 (10012628) was obtained from Cayman Chemical Co. Validated short interfering RNAs (siRNAs) targeting PEX1 (5’-GGACAAGAUUGGUGGGUUAUU-3’),

(4) Proteasome inhibition by VR23 enhances autophagic clearance of FUSP525L-mediated persistent stress granule in SH-SY5Y cellsMolecular BrainJanuary 8, 2026Seong Hyun Kim, Jun Hee So, Yong Hwan Kim, Hyo-Sung Kim, Na Yeon Park, Joon Bum Kim, Doo Sin Jo, Eunbyul Yeom, Jin-A Lee, Ji-Eun Bae, et al.was acquired from Selleck chemicals (S7933, Houston, TX, USA). MG132 was supplied by Cayman Chemical (10012628, Ann Arbor, MI, USA). Antibodies against LC3 (1:2¸000, NB100-2220) and ACTIN (ACTA1, 1:10,000, NB60-501)

(5) The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer CellsAdvanced ScienceJanuary 1, 2026Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, et al.following commercial suppliers: MLN4924 (Apexbio, B1036), CHX (Sigma–Aldrich, C7698), MG132 (Cayman, 10012628), PS341 (MCE, HY‐10227), CQ (Sigma–Aldrich, C6628), Nocodazole (Sigma–Aldrich, M1404), and Paclitaxel

(6) RUNX2 Represses the EWS-FLI1-mediated Transcription in Ewing’s Sarcoma CellsCancer Genomics ProteomicsJanuary 1, 2026TAKAO KITAGAWA, BYRON BARON, HAJIME OKITA, JUNICHI HAMADA, KOJI NAKAGAWA, MASANOBU KOBAYASHI, TOHRU OHTA, YASUHIRO KURAMITSUthree times with PBS(-) and scraped with PBS(-) containing 1 mM PMSF and 10 μM (S)-MG132 (Cat. No. 10012628, Cayman Chemical, Ann Arbor, MI, USA), followed by centrifugation at 6,000 rpm at 4˚C. The cell pellets

(7) PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in miceCell reportsAugust 26, 2025Xu J, Yu T, Yue Z, Lu X, Zhang Y, Wang L, Åhrling SS, Smith MR, Li YC, Matthews J, et al.recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, Mg132,Cayman Chemical,Cat# 10012628; CAS# 133407-82-6 Cycloheximide (CHX),Sigma-Aldrich,Cat# C7698; CAS# 66-81-9 Incomplete Freund’s adjuvants,Sigma-Aldrich,Cat#

(8) Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degenerationAutophagyJuly 1, 2025Tang Q, Tang K, Markby GR, Parys M, Phadwal K, MacRae VE, Corcoran BM.Phalloidin-iFluor 488 Reagent (ab176753) was purchased from Abcam. Rapamycin (13346), torin-1 (10997), MG132 (10012628) and bafilomycin A1 (11038) were obtained from Cayman Chemical. Dimethylsulfoxide (DMSO; 276855) was

(9) The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infectionCell ReportsApril 22, 2025Jessica Sherry, Komal Ishwar Pawar, Lee Dolat, Erin Smith, I-Chang Chang, Khavong Pha, Robyn Kaake, Danielle L. Swaney, Clara Herrera, Eleanor McMahon, et al.Heparin sodium salt was purchased from Sigma (H3393). (S)-MG132 was purchased from Cayman Chemicals (10012628) and Type 1 Collagen from ThermoFisher (A1048301). Plasmid construction The Dre1 gene and various

(10) DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligaseCell Death & DifferentiationApril 1, 2025Xiufang Xiong, Xiaoyu Chen, Shengpeng Shao, Danrui Cui, Ruirui Qu, Baohui Wang, Ying Ma, Hui Pan, Yi Sun, Yongchao Zhaowere maintained in DMEM containing 15% FBS, 1% P/S, and 0.1 mM MEM nonessential amino acids. MG132 (10012628, Cayman) and CHX (C7698, Sigma) were obtained from commercial sources. Generation of DeptorS275A knock-in

(11) CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcriptionMolecular CellDecember 19, 2024Roberta Cacioppo, Alexander Gillis, Iván Shlamovitz, Andrew Zeller, Daniela Castiblanco, Alastair Crisp, Benjamin Haworth, Angela Arabiotorre, Pegah Abyaneh, Yu Bao, et al.and recombinant proteins","Chemicals, peptides, and recombinant proteins" MG-132,Cayman Chemicals,10012628 p97 inhibitor CB-5083,Stratech,S8101-SEL MLN-4924,Tocris,6499/50 triptolide,Cayman Chemicals,CAY11973-5 JQ1,MedChemExpress,HY-13030-10mg AZD4573,Selleckchem,S8719 flavopiridol,Santa

(12) Glucose-6-phosphate dehydrogenase regulates mitophagy by maintaining PINK1 stabilityLife MetabolismDecember 13, 2024Yik-Lam Cho, Hayden Weng Siong Tan, Jicheng Yang, Basil Zheng Mian Kuah, Nicole Si Ying Lim, Naiyang Fu, Boon-Huat Bay, Shuo-Chien Ling, Han-Ming Shenpurchased from Sigma-Aldrich. 6-AN (10009315), 7-aminoactinomycin D (7-AAD) (11397), DHEA (15728), MG132 (10012628), and Q-VD-OPH (15260) were purchased from Cayman Chemical. AG1 (HY-123962) and Spautin-1 (HY-12990)

(13) Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERADNature communicationsOctober 26, 2024Song Z, Thepsuwan P, Hur WS, Torres M, Wu SA, Wei X, Tushi NJ, Wei J, Ferraresso F, Paton AW, et al.examine protein ubiquitination or degradation, cells were treated with 10 μM MG132 (Cayman Chemical 10012628) for 3 hours, or 1 μg/mL brefeldin A (BFA, Cayman Chemical 11861) for 30 minutes followed by 150 μM

(14) Protocol to detect and quantify interactions between proteins expressed in Drosophila S2 cellsSTAR ProtocolsSeptember 20, 2024Cristina C. DeOliveira, Changfan Lin, Brian R. Crane,New England Biolabs,S9102S CLIP-Cell 505,New England Biolabs,S9217S MG-132 proteosome inhibitor,Cayman Chemical,10012628 Magnetic Myc resin,Thermo Fisher Scientific,88842 Magnetic HA resin,Thermo Fisher Scientific,88836 "Mini-PROTEAN

(15) Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagyCell ReportsAugust 10, 2024Jeffrey Knupp, Yu-Jie Chen, Emily Wang, Peter Arvan, Billy Tsai,Thermo Fisher,Cat#P36931 Cycloheximide,VWR,Cat#97064–722 Puromycin,Thermo Fisher,Cat#A1113803 MG132,Cayman Chemical,Cat#10012628 Xestospongin C,Cayman Chemical,Cat# 64950 Purified S1R,Origene,Cat# TP301206 Critical commercial

(16) Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transportersFrontiers in PharmacologyApril 11, 2024Shogo Taniguchi, Francois Berenger, Yukako Doi, Ayana Mimura, Yoshihiro Yamanishi, Tsukasa Okiyonedaused: DMSO (Sigma-Aldrich, St Louis, MO, Cat# D2650), MG-132 (Cayman Chemical, Ann Arbor, MI, Cat# 10012628), Lumacaftor (Cayman Chemical, Cat# 22196), Tezacaftor (Selleck Chemicals, Houston, TX, Cat# S7059),

(17) The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progressionCellFebruary 29, 2024Wang Q, Clark KM, Tiwari R, Raju N, Tharp GK, Rogers J, Harris RA, Raveendran M, Bosinger SE, Burdo TH, et al.,STEMCELL Technologies,78009 Recombinant Human TPO,STEMCELL Technologies,78210 VX765,InvivoGen,tlrl-vad MG132,Cayman Chemical,10012628 Val-boroPro (VbP),Med Chem Express,HY-13233A 1G244,Med Chem Express,HY-116304 PMA,Sigma,P1585 AMD3100,Selleck

(18) USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticityMolecular cancerDecember 13, 2023Kwon J, Zhang J, Mok B, Allsup S, Kim C, Toretsky J, Han C.(CHX; 100 µg/ml) (Thermo Fisher Scientific, Cat#J6690103), MG-132 (10 µg/ ml) (Cayman Chemical, Cat#10012628), Spautin-1 (10 µM) (Selleckchem, Cat#S7888), and 10058-F4 (10 µM) (Selleckchem, Cat#S7153). Mouse

(19) Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage RepairCellsSeptember 6, 2023Réthi-Nagy Z, Ábrahám E, Sinka R, Juhász S, Lipinszki Z.NaCl, 2 mM MgCl2, 0.5 mM EGTA, 0.1% NP-40, 5% glycerol, 1 mM DTT, 1 mM PMSF, 1x PIC, 25 µM MG132 (cat#10012628, Cayman Chemical Company, MI, USA) and 0.1 µL/mL Benzonase nuclease (cat#70746-10KUN, Merck Millipore,

(20) BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1Cell death discoveryAugust 25, 2023Li L, Wang L, Liu D, Zhao Y.described [49]. The following chemicals were obtained from commercial sources: CHX (C7698; Sigma), MG132 (10012628; Cayman), AZD7762 (S1532; Selleck), PF477736 (S2904; Selleck), and LY2603618 (S2626; Selleck). Immunoblotting (IB

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(S)-MG132

MG132

MG132

MG132 from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

Citations (74)

Reviews

MG132 from Cayman Chemical

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