U-73122 from Cayman Chemical

Product Specs
ItemU-73122
CompanyCayman Chemical
Price $275.00Supplier Page View Company Product Page
Catalog Number70740
Research AreaHIV & AIDS, Infectious Disease, Viral Diseases
FormatA crystalline solid
Molecular Weight464.6
Purity≥95%
Storage22
FormulaC29H40N2O3
OriginUSA
TypeInhibitors
Quantity25 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 0.6 µM for platelet aggregation induced by collagen
IC50: 5 µM for platelet aggregatioin induced by thrombin
IC50: 7 µM for HIV-1 integrase

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) A critical signaling role for diacylglycerol in phagocytosis of M. tuberculosisbioRxivMarch 26, 2026Alec Griffith, Michelle Garcia, Gaelen Guzman, Fikadu G. Tafesse(Cayman Chemical, product 10007875) was used at 10 μM. To inhibit PLCγ2 U7311239,47 (Cayman Chemical, product 70740) was used at 5 μM. FB1 (Cayman Chemical, product 62580) was used to reduce cellular ceramides to decrease

(2) Intracellular calcium release activates carotid body afferents by fentanylFunction (Oxf)February 1, 2026Ying-Jie Peng, Oren Kabil, Ning Wang, Zheng Xie, Aaron P. Fox, Nanduri R. PrabhakarµM), YM-254890 (0.5 µM, Cayman Chemical, Cat. No. 29735), or U-73122 (10 µM, Cayman Chemical, Cat. No. 70740) before the addition of fentanyl or vehicle. After treatment, carotid bodies were snap-frozen in liquid

(3) Mechanochemical mechanism underlying intercellular Ca2+ wave propagation and its crucial role in apoptotic cell extrusionNature CommunicationsNovember 17, 2025Sohei Yamada, Ryohei Yasukuni, Yasumasa Bessho, Yasuyuki Fujita, Yoichiroh Hosokawa, Takaaki Matsuisodium (sc-200833; Santa Cruz Biotechnology), 3 µM U73343 (17339; Cayman Chemical Company), 3 µM U73122 (70740; Cayman Chemical Company), 50 µM calpeptin (S7396; selleck chemicals), 1 µM Trametinib (16292; Cayman Chemical Company

(4) Fertilization in the African clawed frog , Xenopus laevis , requires an egg-derived PLC to signal the fast block to polyspermyMicroPubl BiolJuly 30, 2025Kayla M. Komondor, Katherine G. Sharp, Anne E. CarlsonL-glutamine),Thermo Fisher,Cat. No. L1518-500ml Phospholipase C inhibitor U73122,Cayman Chemical,Cat. No. 70740 CAS No. 112648-68-7 PubChem CID: 104794 DMSO,Thermo Fisher,CAS No. 67-68-5 Modified Ringer’s Salts,Thermo

(5) Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavagePLoS BiolJune 17, 2025Jiajia Ma, Tom J. CarneyYM-254890). To inhibit PLCβ, eggs were treated as above but replacing YM-254890 with 100 µM U-73122 (70740, Cayman Chemicals, dissolved in DMSO). For protease inhibitor treatment, Aprotinin (14716, Cayman Chemical)

(6) Effects of Akt Activator SC79 on Human M0 Macrophage Phagocytosis and Cytokine ProductionCellsMay 24, 2024Lee RJ, Adappa ND, Palmer JN.activator,Cayman Chemical (14972) SNAP,NO donor,Cayman Chemical (82250) U73122,PLC inhibitor,Cayman Chemical (70740) U73343,Inactive analogue of U73122,Cayman Chemical (17339) Pharmacological inhibitors and activators

(7) Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteinsThe Journal of biological chemistryMay 1, 2023Kotliar IB, Ceraudo E, Kemelmakher-Liben K, Oren DA, Lorenzen E, Dodig-Crnković T, Horioka-Duplix M, Huber T, Schwenk JM, Sakmar TP.(4013281) was from Bachem. YM254890 (CAS:568580-02-9) was from Wako Pure Chemical Industries. U73122 (70740) was from Cayman Chemical. BRET substrate Prolume Purple (Methoxy e-TZ) (369) was from NanoLight Technology.

(8) Cholesterol-induced robust Ca oscillation in astrocytes required for survival and lipid droplet formation in high-cholesterol conditioniScienceOctober 21, 2022Adachi C, Otsuka S, Inoue T.Industry,D0281; CAS: 524-95-8 Thapsigargin,Nacalai tesque,33637-31; CAS: 67526-95-8 U-73122,Cayman chemical,70740; CAS: 112648-68-7 U-73343,Cayman chemical,17339; CAS: 142878-12-4 Carbenoxolone,Sigma-Aldrich,C4790;

(9) TRPM2 deficiency in mice protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophagesNat Cardiovasc ResApril 1, 2022Zong P, Feng J, Yue Z, Yu AS, Vacher J, Jellison ER, Miller B, Mori Y, Yue L.(Cayman chemical, 14531), PJ-34 (hydrochloride) (Cayman chemical, 14440), U73122 (Cayman chemical, 70740), BAPTA-AM (Cayman chemical, 15551), Apocynin (Cayman chemical, 11976). Recombinant Human Thrombospondin-1

(10) Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiationCell reportsMarch 29, 2022Oh S, Li K, Prince A, Wheeler ML, Hamade H, Nguyen C, Michelsen KS, Underhill DM.Fisher Scientific,Cat# 34580 TRIzol™ Reagent,Invitrogen,Cat# 15596018 U-73122,Cayman Chemical,Cat# 70740; CAS: 112648-68-7 U0126,Tocris Bioscience,Cat# 1144; CAS: 109511-58-2 WGP control / Dectin-1 inhibitor

(11) Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast CancerInternational journal of molecular sciencesFebruary 10, 2022Hirata N, Yamada S, Yanagida S, Ono A, Yasuhiko Y, Nishida M, Kanda Y.and dissolved in water containing 0.1% BSA. 2S-OMPT (#10005707), Ki16425 (#10012659), and U-73122 (#70740) were purchased from Cayman Chemical (Ann Arbor, MI, USA). CysA (BML-A195) was purchased from Enzo Life Sciences

(12) Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin MImmunityMarch 9, 2021Deerhake ME, Danzaki K, Inoue M, Cardakli ED, Nonaka T, Aggarwal N, Barclay WE, Ji RR, Shinohara ML.(Calcineurin inhibitor),Cayman Chemical,Cat#12088 U-73122 (Phospholipase C inhibitor),Cayman Chemical,Cat# 70740 Recombinant mouse GM-CSF,BioLegend,Cat# 576304 Recombinant mouse M-CSF,BioLegend,Cat# 576406 Dynabeads

(13) Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFRThe Journal of experimental medicineDecember 2, 2019Deng M, Guo H, Tam JW, Johnson BM, Brickey WJ, New JS, Lenox A, Shi H, Golenbock DT, Koller BH, et al.Polar Lipids; LysoPAF C-16 (#60906), LysoPAF C18 (#60916), NAC (#20261), m-3M3FBS (#16867), U73122 (#70740), A-804598 (#21256), A-740003 (#21256), VAS2870 (#19205), Ro 20-1724 (#18272), and forskolin (#11018)

(14) A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta ActivationImmunityMarch 19, 2019Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N, Husovsky C, Muir A, Giampazolias E, et al.Lipopolysaccharides from Escherichia coli O111:B4,Sigma,L4391 ATP,Cytoskeleton,BSA04-001 Gefitinib,LC laboratories,G-4408 U-73122 PLC inhibitor,Cayman Chemical,70740 CWHM96/12,David W. Griggs lab,N/A ALK inhibitor SB431542,Abcam,ab120163 Carbon Tetrachloride,Sigma,87031 Brefeldin

(15) Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung CancerCancer cellDecember 10, 2018Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, et al.,Cayman Chemical,13855 Enzastaurin,Selleckchem,S1055 Go6983,R & D Systems,2285 Sotrastaurin,Chemscene,SC-0090 U-73122,Cayman Chemical,70740 Edelfosine,R & D Systems,3022 FIPI,Cayman Chemical,13563 VU0359595,Sigma,SML0566 IWP2,Cayman Chemical,13951 IWP4,Cayman Chemical

(16) UCP2 upregulation promotes PLCγ-1 signaling during skin cell transformationMolecular carcinogenesisOctober 1, 2017Sreedhar A, Lefort J, Petruska P, Gu X, Shi R, Miriyala S, Panchatcharam M, Zhao Y.units/ml, Sigma) to inhibit hydrogen peroxide levels, and PLCγ-1 was inhibited by 5 μM U73122 (Item No 70740, Cayman Chemicals). Western blot analysis Whole Cell Lysates were isolated using RIPA lysis buffer (Santa

(17) Chemerin-induced arterial contraction is G_i- and calcium-dependentVascular pharmacologyJanuary 1, 2017Ferland DJ, Darios ES, Neubig RR, Sjögren B, Truong N, Torres R, Dexheimer TS, Thompson JM, Watts SW.(#1213), and PP1 (#1397) were purchased from Tocris Bioscience (R & D, Minneapolis, MN, USA). U73122 (#70740) was purchased from Cayman Chemical (Ann Arbor, MI, USA). CCX832 was a gift from Chemocentryx (Mountain

(18) Phosphatidylinositol-3-Kinase-Atypical Protein Kinase C Signaling Is Required for Wnt Attraction and Anterior-Posterior Axon GuidanceJournal of NeuroscienceMarch 26, 2008Alex M Wolf, Anna I Lyuksyutova, A. G. Fenstermaker, Beth Shafer, Charles G Lo, Yimin ZounM for “postcrossing assays”; catalog #365250; Calbiochem, San Diego CA), U-73122 (14 ␮M; catalog #70740; Cayman Chemical, Ann Arbor MI), neomycin sulfate (55 ␮M; catalog #El180; Biomol, Plymouth Meeting,

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U-73122

U-73122

U-73122 from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

Citations (18)

Reviews

U-73122 from Cayman Chemical

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