Description
A tyrphostin that is a poor inhibitor of EGFRK (IC50 = 450 µM) and PDGFRK (IC50 > 100 µM) which has been found to inhibit the phosphorylation of ERK1 and ERK2 at 25-50 µM; blocks the production of TNF-α, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response