(±)-Blebbistatin from Cayman Chemical

Product Specs
Item(±)-Blebbistatin
CompanyCayman Chemical
Price $98.00Supplier Page View Company Product Page
Catalog Number13186
Quantity5 mg
FormatA crystalline solid
Molecular Weight292.3
Purity≥98%
TypeInhibitors
Research AreaApoptosis, Cell Biology, Cell Death, Cytoskeleton & Motor Proteins
Storage-20
FormulaC18H16N2O2
OriginCHN

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 0.5-5.0 µM for Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB
IC50: 80 µM for smooth muscle myosin

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction systemElifeJuly 24, 2025Ozanna Burnicka-Turek, Katy A Trampel, Brigitte Laforest, Michael T Broman, Xinan H Yang, Zoheb Khan, Eric Rytkin, Binjie Li, Ella Schaffer, Margaret Gadek, et al.Langendorff perfused heart was electromechanically uncoupled by 15 μM of blebbistatin (Cayman Chemicals 13186) perfusion. A voltage-sensitive fluorescent dye, 80 µM di-4-ANEPPs (Thermo Fisher Scientific D1199),

(2) Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction systemElifeJuly 24, 2025Ozanna Burnicka-Turek, Katy A Trampel, Brigitte Laforest, Michael T Broman, Xinan H Yang, Zoheb Khan, Eric Rytkin, Binjie Li, Ella Schaffer, Margaret Gadek, et al.Langendorff perfused heart was electromechanically uncoupled by 15 μM of blebbistatin (Cayman Chemicals 13186) perfusion. A voltage-sensitive fluorescent dye, 80 µM di-4-ANEPPs (Thermo Fisher Scientific D1199),

(3) The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunctioniScienceFebruary 21, 2025Matthew H. Doran, Michael J. Rynkiewicz, Evan Despond, Meera C. Viswanathan, Aditi Madan, Kripa Chitre, Axel J. Fenwick, Duncan Sousa, William Lehman, John F. Dawson, et al.Alexa Fluor 568 Phalloidin,Thermo fisher,Cat# A12380 EGTA-AM,AAT Boquest,Cat# 99590-86-0 Blebbistatin,Cayman Chemical,Cat# 13186 "WT-ACTC, A331P-ACTC",This paper, ,, Critical commercial assays,Critical commercial assays,Critical

(4) Coordinated Tbx3 / Tbx5 transcriptional control of the adult ventricular conduction systembioRxivNovember 22, 2024Ozanna Burnicka-Turek, Katy A. Trampel, Brigitte Laforest, Michael T. Broman, Zoheb Khan, Eric Rytkin, Binjie Li, Ella Schaffer, Margaret Gadek, Kaitlyn M. Shen, et al.Langendorff Perfused heart was electromechanically uncoupled by 15 μM of blebbistatin (Cayman Chemicals 13186) perfusion. A voltage-sensitive fluorescent dye, 80 µM di-4-ANEPPs (ThermoFisher Scientific D1199),

(5) Susceptibility to innate immune activation in genetically mediated myocarditisJ Clin InvestMay 16, 2024Daniel F. Selgrade, Dominic E. Fullenkamp, Ivana A. Chychula, Binjie Li, Lisa Dellefave-Castillo, Adi D. Dubash, Joyce Ohiri, Tanner O. Monroe, Malorie Blancard, Garima Tomar, et al.CaCl2, 1 mM MgCl2, 10 mM HEPES, 10 mM glucose) supplemented by 15 μM blebbistatin (Cayman Chemical 13186) at physiological pH (7.4) and temperature (37°C). After a 10-minute equilibration period, the perfusate

(6) Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiologyScience AdvancesJuly 7, 2023Zhiyuan Chen, Zexu Lin, Sofian N. Obaid, Eric Rytkin, Sharon A. George, Christopher Bach, Micah Madrid, Miya Liu, Jessica LaPiano, Amy Fehr, et al.performed as previously described (69). Blebbistatin (10 to 15 μM; Cayman Chemicals, catalog number 13186) was added into the perfusion solution to suppress cardiac contractions. For optical mapping of Vm and

(7) Graphene Biointerface for Cardiac Arrhythmia Diagnosis and TreatmentAdvanced MaterialsJune 1, 2023Zexu Lin, Dmitry Kireev, Ning Liu, Shubham Gupta, Jessica LaPiano, Sofian N. Obaid, Zhiyuan Chen, Deji Akinwande, Igor R. EfimovThe cardiac contraction was arrested with 10 ~ 13 µmol blebbistatin (Cayman Chemicals, catalog number 13186), an electromechanical uncoupler that can eliminate contraction in cardiac preparations without effecting

(8) Simultaneous triple-parametric optical mapping of transmembrane potential, intracellular calcium and NADH for cardiac physiology assessmentCommunications BiologyDecember 1, 2022Sharon A. George, Zexu Lin, Igor R. Efimovtreatment After Control recordings, hearts were treated with 15 μM blebbistatin (Cayman Chemicals 13186) for 20 min and optical recordings were acquired as above. Next, hearts were treated with 4-AP (7 mM,

(9) Enhancing iPSC-CMs maturation using a Matrigel-coated micropatterned PDMS substrateCurrent ProtocolsNovember 16, 2022Eric N. Jimenez‐Vazquez, Abhilasha Jain, David K. Jonesacids (Catalog #: 11140-050, Gibco) ʟ-Glutamine (Catalog #: 25030-081, Gibco) Blebbistatin (Catalog #: 13186, Cayman Chemical) Rock inhibitor (Catalog #: Y-27632, Cayman Chemical) β-Mercaptoethanol (Catalog #:

(10) High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zonesJCI InsightFebruary 8, 2022Ching Zhu, Pradeep S. Rajendran, Peter Hanna, Igor R. Efimov, Guy Salama, Charless C. Fowlkes, Kalyanam ShivkumarDMSO, Thermo Fisher Scientific, S1109) into the coronary perfusate. Blebbistatin (Cayman Chemical, 13186) was added to the perfusate at a concentration of 1.7 μg/mL for excitation-contraction uncoupling. Light

(11) Drivers of Sinoatrial Node Automaticity in Zebrafish: Comparison With Mechanisms of Mammalian Pacemaker FunctionFrontiers in physiologyJanuary 1, 2022Stoyek MR, MacDonald EA, Mantifel M, Baillie JS, Selig BM, Croll RP, Smith FM, Quinn TA.fresh modified KH solution containing the excitation-contraction uncoupler ( ± )-blebbistatin (10 μM; 13186, Cayman Chemical, Ann Arbor, MI, United States) to eliminate contraction-induced artifacts in optical

(12) Rotation of stress fibers as a single wheel in migrating fish keratocytesScientific ReportsDecember 1, 2018Chika Okimura, Atsushi Taniguchi, Shigenori Nonaka, Yoshiaki Iwadateself-made small-volume electroporator as described previously58. Blebbistatin treatment (±)-Blebbistatin (13186; Cayman, Ann Arbor, MI) was dissolved at 100 mM in DMSO and then diluted 2,000 times with culture medium.

(13) Shape and Area of Keratocytes Are Related to the Distribution and Magnitude of Their Traction ForcesCell structure and functionMarch 26, 2016Sonoda A, Okimura C, Iwadate Y.calculated. Then, the relationship between the area of the ventral Blebbistatin treatment (±)-Blebbistatin (13186; Cayman, Ann Arbor, MI) was dissolved at 100 mM in DMSO and then diluted 4,000 times with culture medium.

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(±)-Blebbistatin from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

Citations (13)

Reviews

(±)-Blebbistatin from Cayman Chemical

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