Description
A selective estrogen receptor degrader; binds to rat uterine ER (IC50 = 44.8 nM); prevents increases in uterine weight induced by estradiol in immature rats (ED50 = 0.06 mg/kg per day); inhibits the growth of ER-positive MCF-7 human breast cancer cells at 1 µg/ml; prevents tumor growth in MCF-7 and Br10 breast cancer mouse xenograft models at 1 µg/ml; neuroprotective in vitro against neurotoxicity induced by glutamate- and Aβ42