Ki16425 from Cayman Chemical

Product Specs
ItemKi16425
CompanyCayman Chemical
Price $108.00Supplier Page View Company Product Page
Catalog Number10012659
Research AreaCancer, Cell Migration & Metastasis
FormatA crystalline solid
Molecular Weight475
Purity≥95%
Storage-20
FormulaC23H23ClN2O5S
OriginCHN
Quantity5 mg

Specifications/Features

Ki, IC, EC, or working concentration: Ki: 0.34 µM for human LPA1 receptors
Ki: 6.5 µM for Lhuman PA2 receptors
Ki: 0.93 µM for human LPA3 receptors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxietyNature CommunicationsFebruary 6, 2026Thomas Larrieu, Fabio Grieco, Charline Carron, Marta Vilademunt, Crystal Weber, Kyllian Ginggen, Aurélie Delacrétaz, Hector Gallart-Ayala, Mumeko C. Tsuda, Heather A. Cameron, et al.ethanol, Polar Avanti, 474943-13-0), Ki16425 (0.5 mg/ml in ddH20 and 10% ethanol, Cayman Chemical, 10012659), temozolomide (TMZ, from Sigma-Aldrich, T2577), (25 mg/kg; 2.5 mg/ml in 0.9% NaCl i.p.), and rabbit

(2) Inhibition of autotaxin activity with IOA‐289 decreases fibrosis in mouse E0771 breast tumorsInternational Journal of CancerSeptember 15, 2025Xiaoyun Tang, Humayara Khan, Karolina Niewola‐Staszkowska, Frank Wuest, David N. Brindleytimes. Some of the cells were pretreated with 0.5 μM Ki16425, an inhibitor of LPA1 and −3 receptors (10012659, Cayman Chemical, Ann Arbor, Michigan, USA) or 5 μM parthenolide, an inhibitor of NFκB (70080, Cayman Chemical

(3) CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptakeElifeMay 7, 2024Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky×10 objective for 48 hr. For LPAR1/3 inhibitor treatment with KI16425 antagonist (Cayman Chemicals, #10012659), cells were incubated for 1 hr in serum-free medium in 1:1000 dilution prior preparation and assembly

(4) Autotaxin–lysolipid signaling suppresses a CCL11–eosinophil axis to promote pancreatic cancer progressionNature CancerJanuary 9, 2024Sohinee Bhattacharyya, Chet Oon, Luis Diaz, Holly Sandborg, Erin S. Stempinski, Michelle Saoi, Terry K. Morgan, Claudia S. López, Justin R. Cross, Mara H. Shermanused to seed 5 × 105 PDAC cells per well in six-well plates. Cells were treated with Ki16425 (Cayman, 10012659), H2L5186303 (Cayman, 14663) or HA130 (Echelon Bioscience, B-0701) for 24 h the following day, when

(5) LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cellsGliaMarch 1, 2023Shannon Weber Doutt, Jody Fromm Longo, Steven L. Carrollwas purchased from Avianti Polar Lipids (Alabaster, AL; # 857128X). The LPAR1/3 inhibitor Ki16425 (#10012659) was purchased from Cayman Chemical Company (Ann Arbor, MI) and the selective ROCK1/2 inhibitor Y26732

(6) Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast CancerInternational journal of molecular sciencesFebruary 10, 2022Hirata N, Yamada S, Yanagida S, Ono A, Yasuhiko Y, Nishida M, Kanda Y.PEPROTECH (Rocky Hill, NJ, USA) and dissolved in water containing 0.1% BSA. 2S-OMPT (#10005707), Ki16425 (#10012659), and U-73122 (#70740) were purchased from Cayman Chemical (Ann Arbor, MI, USA). CysA (BML-A195) was

(7) Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 AxisCellular and molecular gastroenterology and hepatologyJanuary 1, 2022Qiu H, Song E, Hu Y, Li T, Ku KC, Wang C, Cheung BMY, Cheong LY, Wang Q, Wu X, et al.(9903; Cell Signaling Technology), wortmannin (W1628; Sigma), PF8380 (12018; Cayman), and Ki16425 (10012659; Cayman) at the concentration specified in each figure legend. For luciferase reporter assay, Huh7 cells

(8) Optical Control of Phosphatidic Acid SignalingACS central scienceJuly 28, 2021Tei R, Morstein J, Shemet A, Trauner D, Baskin JM.experiments with LPA receptor inhibitor, cells were pretreated with 10 μM Ki16425 (Cayman Chemical Company, 10012659) for 1 h. Immunofluorescence analysis was performed as described above, and primary antibody incubation

(9) Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signalingCommunications biologyJune 24, 2021Jiang Y, Guo Y, Hao J, Guenter R, Lathia J, Beck AW, Hattaway R, Hurst D, Wang QJ, Liu Y, et al.Sigma-Aldrich. The PKD inhibitor CRT0066101 (A8679) was purchased from APExBio. The LPA inhibitor Ki16425 (10012659) was purchased from Cayman Chemical Company. Gelatin (9000-70-8) was purchased from Bio-Rad. The reagents

(10) N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell MetastasisDevelopmental cellNovember 18, 2019Juin A, Spence HJ, Martin KJ, McGhee E, Neilson M, Cutiongco MFA, Gadegaard N, Mackay G, Fort L, Lilla S, et al.α-Lysophosphatidic Acid Sodium Salt),Sigma,L7260 DMSO,Fisher Chemical,15572393 KI16425,Cayman Chemicals,10012659 Primaquine,Sigma,160393 17:0 Lyso PA 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphate (Sodium Salt),Avanti

(11) Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA₁Evidence-Based Complementary and Alternative MedicineNovember 3, 2019Hui Wang et al.various LPA doses (0, 5, and 10 μM) for 24 h, respectively. When selecting the suitable Ki16425 (Cayman, 10012659) content, cells were plated with various Ki16425 doses (0, 10, and 20 μM) for 24 h, respectively. Afterwards,

(12) Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell ProliferationCancer prevention research (Philadelphia, Pa.)May 1, 2016Volden PA, Skor MN, Johnson MB, Singh P, Patel FN, McClintock MK, Brady MJ, Conzen SD.dissolved in PBS with 1% BSA 2.5mM, and then stored in aliquots at −80 °C until use. Ki16425 (Cayman Chem., 10012659), H2L5186303 (Tocris Bio., 4878), and PF-8380 (Calbiochem, 189512) were purchased in DMSO solution and

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Ki16425

Ki16425

Ki16425 from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

Citations (12)

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Ki16425 from Cayman Chemical

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