Description
A CB1 receptor antagonist and CB2 receptor agonist; inhibits the binding of [3H]-WIN 55,212-2 to CHO-K1 cells expressing the human CB2 receptor or rat cerebellar membranes (IC50s = 41 and 313 nM, respectively); reduces food intake and weight gain in ob/ob mice and reverses (R)-methanandamide-induced analgesia in mice at 20 mg/kg; decreases infarct volume and demyelination in a neonate rat model of hypoxia-ischemia-induced brain injury at 1 mg/kg