Description
A selective estrogen receptor modulator; binds to the estrogen receptor (IC50 = 0.4 nM); exhibits estrogenic activity in bone cells without stimulating breast or endometrial tissue; guards endothelial cells obtained from rat aortic rings against oxidative insult at 1 µM and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg); inhibits Kv4.3 (IC50 = 2 µM)