Description
An IP receptor antagonist; selective for the IP receptor over EP1, EP2, EP3, EP4, FP, and TP receptors and a panel of 30 other receptors and ion channels but does bind α2A-adrenergic and imidazoline I2 receptors; inhibits carbaprostacyclin-induced cAMP accumulation in SH-SY5Y cells (pKB = 8.8) and cicaprost-induced vasorelaxation of isolated human pulmonary arteries (pA2 = 8.2); decreases cicaprost-induced inhibition of platelet aggregation in human platelet-rich plasma; reduces acetic acid-induced writhing and carrageenan-induced paw hyperalgesia in rats (ED50s = 4 and 2.8 mg/kg, respectively)