L-161,982 from Cayman Chemical

Product Specs
ItemL-161,982
CompanyCayman Chemical
Price $178.00Supplier Page View Company Product Page
Catalog Number10011565
Research AreaCyclooxygenase Pathway, Immunology & Inflammation, Inflammatory Lipid Mediators, Innate Immunity, Lipid Biochemistry, Prostaglandins
FormatA crystalline solid
Molecular Weight654.7
Purity≥95%
Storage-20
FormulaC32H29F3N4O4S2
OriginUSA
Quantity5 mg

Specifications/Features

Ki, IC, EC, or working concentration: Ki: 0.024 µM for EP4 receptor
Ki: 17 µM for EP1 receptor
Ki: 23 µM for EP2 receptor
Ki: 1.9 µM for EP3 receptor
Ki: 5.1 µM for DP receptor
Ki: 5.6 µM for FP receptor
Ki: 6.7 µM for IP Receptor

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Hyperactive Enteric Glia Contribute to Persistent Dysmotility Following Inflammation by Driving Aberrant Excitatory Responses in NeuronsCellular and Molecular Gastroenterology and HepatologyJanuary 1, 2026Luisa Seguella, Beatriz Thomasi, Silvia Basili Basili Franzin, Jonathon L. McClain, Rafaella Lavalle, Aurora Zilli, Visha Parmar, Giuseppe Esposito, Brian D. Gulbransenantagonist L-798, 106 (10 μM; 11129, Cayman Chemical) and EP4 receptors antagonist L-161, 982 (50 μM; 10011565, Cayman Chemical) to block prostaglandin receptors. Tissue Movement Tissue displacement was analyzed

(2) Membrane disruption attenuates agonist potency in prostanoid receptorsBiochemical JournalOctober 17, 2025Uurtuya Hochban, Imke Wallenstein, Michaela Ulrich, Alwina Bittner, Lisa Spänig, Katharina Klingelhöfer, Sebastian Neumann, Torsten Steinmetzer, Moritz Bünemann, Michael Kurzconformation sensor CAM [19]. In this study, we used PGE2 (14010), PGD2 (12010), U-46619 (16450), L-161,982 (10011565), Iloprost (18215), and 11-deoxy PGE2 (14520) (all from Cayman Chemical, Ann Arbor, Michigan, U.S.A.)

(3) Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2Nat CommunMarch 28, 2025Candice Sakref, Alexis Saby, Céline Rodriguez, Maude Ardin, Lyvia Moudombi, Anne-Claire Doffin, Elisa Gobbini, Aurélien Voissiere, Laurie Besson, Léo Laoubi, et al.antagonist obtained from Cayman Chemical (respectively: PF-04418948, ref: 15016 and L-161,982, ref: 10011565). Isolated pDCs were incubated 1 h with inhibitors at the indicated concentration before adding tumor

(4) Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptorsScience SignalingNovember 21, 2023Wilmarie Morales-Soto, Jacques Gonzales, William F. Jackson, Brian D. Gulbransenincubated for 30min with or without IL-1β (10 μg/mL) and either 43Gap26 (100 μM) or L-161,982 (50μM; 10011565, Cayman Chemical) to disrupt the release of glial mediators through Cx43 and inhibit EP4 receptors on

(5) The endocannabinoid anandamide is an airway relaxant in health and diseaseNat CommunNovember 17, 2022Annika Simon, Thomas von Einem, Alexander Seidinger, Michaela Matthey, Laura Bindila, Daniela WenzelIndometacin (Indo, 70270, Cayman Chemical, USA), KCl (P9333, Sigma-Aldrich, Germany), L-161,982 (L, 10011565, Cayman Chemical, USA), MJN110 (MJN, 17583, Cayman Chemical, USA), Nordihydroguaiaretic Acid (NDGA,

(6) The Succinate Receptor SUCNR1 Resides at the Endoplasmic Reticulum and Relocates to the Plasma Membrane in Hypoxic ConditionsCellsJuly 13, 2022Sanchez M, Hamel D, Bajon E, Duhamel F, Bhosle VK, Zhu T, Rivera JC, Dabouz R, Nadeau-Vallée M, Sitaras N, et al.were: succinate (Sigma Saint Louis, MO, USA; #S3674), L-161,982 (Cayman Chemical, Ann Arbor, MI, USA; #10011565), and prostaglandin E2 (Cayman Chemical; #14010). 2.3. Immunohistochemistry Localization of endogenous

(7) COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced ObesityCellsJune 2, 2022Chunqing Wang et al.Thermo Fisher Scientific (Waltham, MA, USA). PGD2 (41598-07-6), PGE2 (14010), PGI2 (69552-46-1), L-161,982 (10011565), TG6-10-1 (23444), SC-51089 (10011561), and Rosiglitazone (71740) were obtained from Cayman Chemical Company

(8) EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis modelThe Journal of experimental medicineMay 2, 2022Tao X, Zhang R, Du R, Yu T, Yang H, Li J, Wang Y, Liu Q, Zuo S, Wang X, et al.purchased SC-51322 (#10010744), PF-04418948 (#15016), L-798,106 (#11129), sulprostone (#14765), L161982 (#10011565), SQ29548 (#19025), CAY10441 (#10005186), AL8810 (#16735), and BW A868C (#12060) from Cayman Chemical.

(9) mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathwayCell death & diseaseApril 6, 2020Li Y, Chen J, Yang W, Liu H, Wang J, Xiao J, Xie S, Ma L, Nie D.inhibitor SC-19220 (14060), EP2 receptor inhibitor AH-6809 (14050) and EP4 receptor inhibitor L-161982 (10011565) were purchased from Cayman Chemical Company (Ann Arbor, MI, USA). The EP3 receptor inhibitor L-798106

(10) Prostaglandin E₂Inhibits the Ability of Neutrophils to KillListeria monocytogenesThe Journal of ImmunologyJune 15, 2019Michelle G. Pitts, Sarah E. F. D’OrazioEP-2 antagonist PF-04418948 (Cayman Chemical # 15016) or EP4-antagonist L-161,982 (Cayman Chemical # 10011565) suspended in DMSO and diluted in RP10(−) at a final concentration of 100 nM. Neutrophil migration Neutrophil

(11) TLR4 signaling promotes a COX-2/PGE₂/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cellsOncoimmunologyFebruary 1, 2016Lin A, Wang G, Zhao H, Zhang Y, Han Q, Zhang C, Tian Z, Zhang J.Calbiochem. Selective EP1/2 receptor antagonist AH6809 (14050) and EP4 receptor antagonist L-161, 982 (10011565) were purchased from Cayman Chemical. Selective EP3 receptor antagonist L-798, 106 (sc-204047) was purchased

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L-161,982

L-161,982

L-161,982 from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

Citations (11)

Reviews

L-161,982 from Cayman Chemical

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