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Pifithrin-α
Pifithrin-α from Cayman Chemical
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Citations:
(2)
Supplier Page
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Cayman Chemical for
Pifithrin-α
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Description
An inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis, preventing p53-mediated apoptosis by cytotoxic compounds in C8 cells at 10 µM and in human umbilical vein endothelial cells at 30 µM
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Pifithrin-α
Company
Cayman Chemical
Price
$112.00
Supplier Page
View Company Product Page
Catalog Number
13326
Quantity
10 mg
Research Area
Apoptosis, Cell Biology, Cell Death, Cell Signaling, Epigenetics, Transcription, & Translation, Transcription Factors
Format
A crystalline solid
Molecular Weight
367.30494
Purity
≥95%
Storage
-20
Formula
C16H18N2OS • HBr
Origin
USA
Type
Inhibitors
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Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (2)
(1)
Pharmacologic inhibition of BMI1 exerts antitumor effects against MYCN-amplified neuroblastoma, with activation of the p53 pathway
Sci Rep
July 2, 2025
Masahiro Hirayama, Eri Yamada, Hiromasa Aoki, Kazuya Izumi, Ayumi Amano, Kohki Toriuchi, Koichi Ogami, Mai Nagasaka, Yasumichi Inoue, Hidetoshi Hayashi,
et al.
as a tubulin polymerization
inhibitor
, and pifithrin-α (C16H18N2OS・HBr,
Cayman Chemical
, catalog no.
13326
) was used to
inhibit
p53. For
assays
, these compounds were dissolved in DMSO.
Cell viability assay
Cell
(2)
TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression
Molecular cell
November 17, 2016
Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C,
et al
.
Cayman Chemical
, #
10748
) or pifithrin-α (
inhibitor
of p53 dependent transcriptional activation,
Cayman Chemical
, #
13326
) dissolved in 1% EtOH/30% PEG/1% Tween-80) was injected intraperitoneally into one-week-old WT and TRAF6
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Pifithrin-α from Cayman Chemical
Supplier Page
View Company Product Page
$112.00
Product Specs
Company Info
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