MEK Inhibitor U0126 from Promega

Product Specs
ItemMEK Inhibitor U0126
CompanyPromega
Price Supplier Page View Company Product Page
Catalog NumberV1121
Quantity5mg

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Promega

2800 Woods Hollow Rd

Madison, WI 53711

United States

Phone: Tel: +1 (608) 274-4330
Fax: +1 (608) 277-2516

Email: custserv@promega.com
techserv@promega.com

Company Profile

Website: http://www.promega.com

(1) Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neuronsCell Death & DiseaseFebruary 11, 2026Emily Blackburn, Nicol Birsa, André Teixeira Lopes, Elizabeth M. C. Fisher, Oscar M. Lazo, Giampietro Schiavo168808; http://n2t.net/addgene:168808; RRID:Addgene_168808) [72]. ERK inhibitor U1026 was from Promega (V1121). Primary antibodies for immunofluorescence (IF) and western blot (WB) were sourced as follows: MAP2

(2) Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate CionaElifeJune 18, 2025Akiko Hozumi, Nozomu M Totsuka, Arata Onodera, Yanbin Wang, Mayuko Hamada, Akira Shiraishi, Honoo Satake, Takeo Horie, Kohji Hotta, Yasunori Sasakura#010-02441) or 1 mM theophylline (Sigma-Aldrich #T1633) dissolved in seawater, or 4 μM U0126 (Promega #V1121) dissolved in DMSO. Plasmids The open reading frame (ORF) of Kaede was removed from pSPCiPC2Kaede

(3) Mixed lineage kinase (MLK) controls tumor development and angiogenesisAngiogenesisMay 2, 2025Shashi Kant, Amada D. Caliz, Hyung-Jin Yoo, Gaganpreet Kaur, Heather Learnard, Hassan A. Khalil, Roger J. Davis, John F Jr Keaneybefore treatment with either vehicle (DMSO), 10 μM ERK pathway inhibitor (MEK inhibitor, U0126, Promega V1121, Madison, WI), or 20 μM p38 MAPK inhibitor (SB203580. Tocris Bioscience, #1202, Bio-Techne, Minneapolis,

(4) Prevention of liver metastasis via the pharmacological suppression of AMIGO2 expression in tumor cellsScientific ReportsNovember 15, 2024HeeKyung Seong, Yusuke Kanda, Runa Izutsu, Jumond P. Jehung, Junichi Hamada, Mitsuhiko Osaki, Koji Okamoto, Futoshi OkadaChemical Corporation (Osaka, Japan); SP600125 (S1460) from Selleck Biotech (Yokohama, Japan); and U0126 (V1121) from Promega (Madison, WI, USA). All compounds were freshly dissolved in DMSO (048-21985, Fujifilm

(5) ERK1/2 mitogen‐activated protein kinase dimerization is essential for the regulation of cell motilityMolecular OncologySeptember 12, 2024Dalia de la Fuente‐Vivas, Vincenzo Cappitelli, Rocío García‐Gómez, Sara Valero‐Díaz, Camilla Amato, Javier Rodriguéz, Santiago Duro‐Sánchez, Alexander von Kriegsheim, Michael Grusch, José Lozano, et al.NJ, USA). DEL 22379 was synthesized at Vichem Chemie (BUdapest, Hungary). U0126 was from Promega (#V1121, Madrid, Spain). All experiments were performed using mycoplasma free cells (Fig. S1). LookOut Mycoplasma qPCR Detection Kit

(6) Epithelial-derived interleukin 23 (IL-23) promotes oral mucosal immunopathologyImmunityApril 9, 2024Tae Sung Kim, Tomoko Ikeuchi, Vasileios Ionas Theofilou, Drake Winslow Williams, Teresa Greenwell-Wild, Armond June, Emmanuel E. Adade, Lu Li, Loreto Abusleme, Nicolas Dutzan, et al.tlrl-pafla LPS-E.coli,Sigma-Aldrich,Cat#: L6529 LPS-Pseudomonas aeruginosa,Sigma-Aldrich,Cat#: L9143 U0126,Promega,Cat#: V1121 SB203580,Sigma-Aldrich,Cat#: 559389–10MG SP600125,Sigma-Aldrich,Cat#: 420119–5MG BAY 11–7082,Sigma-Aldrich,Cat#:

(7) IL-10 dependent adaptation allows macrophages to adjust inflammatory responses to TLR4 stimulation historybioRxivApril 5, 2024H. Bongartz, C. Bradfield, J. Gross, I.D.C. Fraser, A. Nita-Lazar, M. Meier-SchellersheimMethods Materials Kdo2-Lipid A (KLA) was purchased from Avanti Polar Lipids. Mek inhibitor U0126 (V1121) was obtained from Promega and re-constituted in DMSO (Sigma-Aldrich, D8418). The Alexa Fluor™ 647-conjugated

(8) MEK1-ERK1/2 signaling regulates the cardiomyocyte non-sarcomeric actin cytoskeletal networkAmerican Journal of Physiology-Heart and Circulatory PhysiologyJanuary 1, 2024Kelly M. Grimes, Marjorie Maillet, Casey O. Swoboda, Stephanie L. K. Bowers, Doug P. Millay, Jeffery D. Molkentinone cohort of NRVMs not infected with adenoviruses was treated with 10 µM U0126 (Promega, Cat. No. V1121) for 1 h in serum-free M199 before fixation or homogenization. The β-galactosidase, eGFP, and activated

(9) SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and MiceResearch (Wash D C)November 14, 2023Xiujuan Du, Yuhua Yan, Juehua Yu, Tailin Zhu, Chu-Chung Huang, Lingli Zhang, Xingyue Shan, Ren Li, Yuan Dai, Hui Lv, et al.prior to behavioral testing, mice were injected in situ with either U0126 (Promega, USA, catalog no. V1121) dissolved in 10% DMSO or vehicle alone. Behavioral protocols Y-maze. The Y-maze test is a common

(10) Regulation of programmed death ligand 1 (PD‐L1) expression by TNF‐related apoptosis‐inducing ligand (TRAIL) in triple‐negative breast cancer cellsMolecular CarcinogenesisFebruary 1, 2023Julio M. Pimentel, Jun‐Ying Zhou, Gen Sheng WuRecombinant Human sTRAIL/Apo2L (catalog no. 310-04) was purchased from PeproTech. The MEK inhibitor U0126 (catalog no. V1121) was purchased from Promega. Trypsin-EDTA (catalog no. 25300-054), DMEM (catalog no. 11995-065), bovine

(11) Anti‑oncogenic and pro‑myogenic action of the MKK6/p38/AKT axis induced by targeting MEK/ERK in embryonal rhabdomyosarcomaOncology reportsSeptember 1, 2022Di Rocco A, Camero S, Benedetti A, Lozanoska-Ochser B, Megiorni F, Marchese C, Stramucci L, Ciccarelli C, Bouché M, Bossi G, et al.MilliporeSigma) for 1 day, 10 µM U0126 MEK inhibitor for 3 h, overnight (O/N), 1 day or 3 days (cat. no. V1121; Promega Corporation) or 10 nM trametinib for 3 h, overnight (O/N) or 3 days (cat. no. SC-364639; Santa Cruz Biotechnology, Inc

(12) A Systems Biology Approach to Investigate Kinase Signal Transduction Networks That Are Involved in Triple Negative Breast Cancer Resistance to CisplatinJournal of Personalized MedicineAugust 3, 2022Nupur Mukherjee et al.AICAR (Acadesine) (NA03552) and QNZ (EVP4593) (1237744-13-6) were purchased from Carbosynth, and U0126 (V1121) was purchased from Promega. QNZ (EVP4593), Ipatasertib, Stattic, CHIR-98014, PF-4708671, AICAR (Acadesine),

(13) Transglutaminase 2 enhances hepatocyte growth factor signaling to drive the mesothelioma cancer cell phenotypeMolecular CarcinogenesisJune 1, 2022Warren Naselsky, Gautam Adhikary, Suruchi Shrestha, Xi Chen, Geraldine Ezeka, Wen Xu, Joseph S Friedberg, Richard L. EckertERK1/2-inhibitor LY3214996 (S8534) was obtained from Selleckchem (Houston, TX) and the MEK1/2-inhibitor U0126 (V1121) was purchased from Promega (Madison, WI). Anti-transglutaminase 2 (TG2) (MAB3839) and SGX-523 MET inhibitor

(14) Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathwaysCommunications biologyMay 30, 2022Zhen Y, Cullen CL, Ricci R, Summers BS, Rehman S, Ahmed ZM, Foster AY, Emery B, Gasperini R, Young KM.complete culture medium. Delivery of pharmacological agents to OPCs The MEK inhibitor (U0126, Promega, V1121), Arp2/3 inhibitor (CK666, Millipore, 182515) and Cdc42 inhibitor (ML141, Sigma, SML0407) were reconstituted

(15) Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinomaCell death & diseaseMay 25, 2022Zheng ZY, Chu MY, Lin W, Zheng YQ, Xu XE, Chen Y, Liao LD, Wu ZY, Wang SH, Li EM, et al.beneficial for ESCC therapy. Materials and methods Reagents and antibodies The MEK1/2 inhibitor U0126 (V1121) was purchased from Promega. Trametinib (MEK1/2 inhibitor, HY-10999), Stattic (STAT3 inhibitor, HY-13818),

(16) Rgs4 is a regulator of mTOR activity required for motoneuron axon outgrowth and neuronal development in zebrafishScientific ReportsDecember 1, 2021Aya Mikdache, Marie-José Boueid, Lorijn van der Spek, Emilie Lesport, Brigitte Delespierre, Julien Loisel-Duwattez, Cindy Degerny, Marcel Tawktreatment Embryos were incubated in either 10 μM of Ly294002 (Cell signaling, #9901), 20 μM of U0126 (Promega, #V1121) or a combination of both, 10 μM of Rapamycin (Sigma, #R0395) and 50 μM of MHY1485 (Sigma, #SML0810),

(17) Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce CD14, TLR4, and MMP9 Expression during Monocyte-to-Macrophage Differentiation: Potential Therapeutic Implications for AtherosclerosisAntioxidants (Basel, Switzerland)November 11, 2021Njau F, Haller H.protease inhibitors PMSF (phenylmethanesulfonyl fluoride; P7626) and leupeptin (L851). The MAPK inhibitor (U0126; V1121) was from Promega, (Walldorf, Germany), while the PKCδ inhibitor rottlerin (sc-3550) and the calpain

(18) A cell-based drug discovery assay identifies inhibition of cell stress responses as a new approach to treatment of epidermolysis bullosa simplexJournal of Cell ScienceOctober 1, 2021Tong San Tan, John E. A. Common, John S. Y. Lim, Cedric Badowski, Muhammad Jasrie Firdaus, Steven S. Leonardi, E. Birgitte Laneeither glass coverslips, dishes or plates prior to DMSO and drug treatments. The MEK inhibitor U0126 (#V1121, Promega Corporation, WI, USA) and the EGFR inhibitors AG1478 (#658552, Calbiochem, MA, USA), lapatinib

(19) Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasioneLifeSeptember 30, 2021Harada A, Matsumoto S, Yasumizu Y, Shojima K, Akama T, Eguchi H, Kikuchi A.,Thermo Fisher Scientific,"23,227", "Chemical compound, drug",PD184161,Sigma-Aldrich,PZ0112, "Chemical compound, drug",U0126,Promega Corp.,V1121, "Chemical compound, drug",Rapamycin,Cell Signaling Technology,"9,904", "Chemical compound, drug",LY294002,Cell Signaling Technology

(20) Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesisEMBO reportsFebruary 3, 2021Nitzsche A, Pietilä R, Love DT, Testini C, Ninchoji T, Smith RO, Ekvärn E, Larsson J, Roche FP, Egaña I, et al.retrieval and lysis of hearts or lungs at specific time points and immunoblotting. MEK inhibitor U0126 (V1121, Promega) was injected intraperitoneally (5 mg/kg). For short treatment, pups were injected twice at

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