Description
Ubiquitous lipid species generated following PLA2 hydrolysis of phosphatidylcholine; increases the production of ROS and decreases SOD and eNOS protein levels and phosphorylation of ERK1/2 in HUVECs at 125 µM; potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages at 0.3-1.0 µM; increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood at 10 µM; enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis at 10 mg/kg