NS 398 from Cayman Chemical

Product Specs
ItemNS 398
CompanyCayman Chemical
Price $55.00Supplier Page View Company Product Page
Catalog Number70590
Quantity5 mg
Research AreaCyclooxygenase Pathway, Immunology & Inflammation, Inflammatory Lipid Mediators, Lipid Biochemistry, Prostaglandins
FormatA crystalline solid
Molecular Weight314.4
Purity≥98%
Storage22
FormulaC13H18N2O5S
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Prevention of liver metastasis via the pharmacological suppression of AMIGO2 expression in tumor cellsScientific ReportsNovember 15, 2024HeeKyung Seong, Yusuke Kanda, Runa Izutsu, Jumond P. Jehung, Junichi Hamada, Mitsuhiko Osaki, Koji Okamoto, Futoshi Okadatrametinib (CS-0060) from ChemScene (Monmouth Junction, NJ, USA); JAK inhibitor I (15146) and NS398 (70590) from Cayman Chemical (Ann Arbor, MI, USA); MEK inhibitor I (444937) and VEGF receptor tyrosine kinase inhibitor

(2) Fluorinated Benzofuran and Dihydrobenzofuran as Anti-Inflammatory and Potential Anticancer AgentsInternational Journal of Molecular SciencesJune 20, 2023Abeer J. Ayoub, Ghewa A. El-Achkar, Sandra E. Ghayad, Layal Hariss, Razan H. Haidar, Leen M. Antar, Zahraa I. Mallah, Bassam Badran, René Grée, Ali Hachem, et al.basal COX (Figure 3C). In this setting, 1 µM NS398, a selective COX-2 inhibitor (Cayman Chemicals, 70590), decreased PGE2 synthesis by 63% (data not shown). Figure 3B shows that compounds 3 and 6 significantly

(3) Protein adduction causes non-mutational inhibition of p53 tumor suppressorCell reportsJanuary 31, 2023Caspa Gokulan R, Paulrasu K, Azfar J, El-Rifai W, Que J, Boutaud OG, Ban Y, Gao Z, Buitrago MG, Dikalov SI, et al.(4-hydroxy-2,2,6,6-tetramethylpiperydine-1-oxyl)",Enzo Lifesciences,Cat# ALX-430-081-G001 NS-398,Cayman Chemical,Cat#70590 2-HOBA,Cayman Chemical,Cat#25357 Critical commercial assays,Critical commercial assays,Critical commercial

(4) NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent MechanismImmunoHorizonsAugust 29, 2022Hamilton C, Olona A, Leishman S, MacDonald-Ramsahai K, Cockcroft S, Larrouy-Maumus G, Anand PK.were exposed to IL-1 (2 ng/ml, 211-11B; PeproTech), cyclooxygenase 2 (COX2) inhibitor NS-398 (10 μM, 70590; Cayman), or protein kinase A (PKA) inhibitor H-89 (10 μM, 10010556; Cayman) overnight. For fatty acid

(5) Dedifferentiation of Human Cardiac Myofibroblasts Is Independent of Activation of COX-2/PGE₂ PathwayInternational journal of molecular sciencesMarch 11, 2022Luu VT, Phan S, Jin ZQ.PMA (#1585) and DMSO (#8418) were purchased from Sigma-Aldrich (St. Louis, MO, USA). PGE2, NS-398 (#70590) and PF-04418948 (#15016) were purchased from Cayman Chemical (Ann Arbor, MI, USA). Recombinant human

(6) Inflammatory Signaling and DNA Damage Responses after Local Exposure to an Insoluble Radioactive MicroparticleCancers (Basel)February 18, 2022Yusuke Matsuya, Nobuyuki Hamada, Yoshie Yachi, Yukihiko Satou, Masayori Ishikawa, Hiroyuki Date, Tatsuhiko Sato(AG-CR1-0013-M010, AdipoGen, San Diego, CA, USA) as an inhibitor of the NF-κB nuclear translocation, 50 μM NS-398 (70590, Cayman Chemical, Ann Arbor, MI, USA) as the COX-2 inhibitor, or both. As these inhibitors were solved

(7) Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysisCell metabolismJune 1, 2021Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, Alimirah F, Kim DE, Payne T, Rosko A, et al.Recombinant Proteins","Chemicals, Peptides, and Recombinant Proteins" NS-398,Cayman Chemical Company,70590 CAY-10404,Cayman Chemical Company,70210 Ciglitazone,Cayman Chemical Company,71730 Troglitazone,Cayman Chemical Company

(8) Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogrammingNature communicationsFebruary 20, 2019Muraoka N, Nara K, Tamura F, Kojima H, Yamakawa H, Sadahiro T, Miyamoto K, Isomi M, Haginiwa S, Tani H, et al.345-FG-025). Diclofenac (10 μM, Calbiochem, 287840), SC-560 (10 μM, Cayman, 70340), NS-398 (10 μM, Cayman, 70590), celecoxib (10 μM, Cayman, 10008672), acetylsalicylic acid (10 μM, Sigma Aldrich, A5376), PGD2 (1 μM,

(9) Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivoFrontiers in immunologyJanuary 1, 2019Lewis A, Elks PM.(Cayman Chemical, 70340), was used at 30 μM and the selective inhibitor of COX-2, NS-398 (Cayman Chemical, 70590), was used at 15 μM by incubation in E3 embryo media (32). The 15-LOX inhibitor PD146176 (Tocris, 2850)

(10) Inhibition of Intestinal Epithelial Wound Healing through Protease-Activated Receptor-2 Activation in Caco2 CellsJournal of Pharmacology and Experimental TherapeuticsNovember 1, 2018Elizabeth H. Fernando, Marilyn H. Gordon, Paul L. Beck, Wallace K. MacNaughtonOntario, Canada) was added at 0 and 24 hours (5 and 20 ng/ml). The selective COX-2 inhibitor NS-398 (70590 Cayman) was added to cells at 0 and 24 hours (10 mg/ml), and an equivalent volume of dimethylsulfoxide

(11) Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary HypertensionCirculation researchJune 8, 2018Tamosiuniene R, Manouvakhova O, Mesange P, Saito T, Qian J, Sanyal M, Lin YC, Nguyen LP, Luria A, Tu AB, et al.inhibitor, zinc (II) Protoporphyrin IX (number 691550) and selective COX-2 inhibitor NS-398, (number 70590) was purchased from Cayman Chemical (Ann Arbor, MI). Tregs (CD4 CD25 + ) Isolation and IR high Rat

(12) Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathwaysOncotargetSeptember 26, 2017Ivanov VN, Wu J, Hei TK.MN). Cannabidiol (exempt preparation; #90081); AM251 (#71670); SR144528 (#192703-06-3) and NS398 (#70590) were obtained from Cayman Chemical (Ann Arbor, MI). Human embryonic neural stem cells (NSC) in culture Cryopreserved

(13) Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transportNature cell biologySeptember 1, 2014Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, et al.(Sigma, S2064), AH23848 (Sigma, A8227) were dissolved in DMSO for a 50 mM stock solution. NS398 (Cayman, 70590) and Indomethacin (Sigma, I7378) were dissolved in DMSO to a 100 mM stock solution. Embryos were incubated

(14) Benign prostatic hyperplasia (BPH) epithelial cell line BPH-1 induces aromatase expression in prostatic stromal cells via prostaglandin E2Journal of EndocrinologyOctober 4, 2007Quan Wu, Ying Zhou, Linfeng Chen, Jiandang Shi, Chun-Yu Wang, Lin Miao, Helmut Klocker, Irwin Park, Chung Lee, Ju Zhangresponsible for the induction of aromatase expression is indeed PGE2, we added NS-398 (Cayman, Cat No. 70590), a COX-2 specific inhibitor, into the culture medium of BPH-1 cells. The PGE2 concentration in NS-398-treated

(15) VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitroOncology ReportsJuly 1, 2007Xiaoyan Shi, Gang Chen, Hui Xing, Danhui Weng, Xiangyang Bai, Ding Ma(Minneapolis, MN). Rabbit polyclonal antibody to cyclooxygenase-2 (COX-2) and its specific inhibitor NS398 (70590), were purchased from Cayman Chemical (Ann Arbor, MI). Transwell plate (24-well) and the PET membrane

(16) Activated macrophages infected with Legionella inhibit T cells by means of MyD88-dependent production of prostaglandinsJournal of immunology (Baltimore, Md. : 1950)December 15, 2005Neild AL, Shin S, Roy CR.indomethacin (COX1/COX2 inhibitor; Cayman Chemical 70270), or 5 ␮M NS-398 (COX2 inhibitor; Cayman Chemical 70590) for 5 h before infection with dotA mutant Legionella (MOI 20). Intracellular growth curves ELISAs

(17) Cell-cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expressionCell death and differentiationFebruary 1, 2004Bizik J, Kankuri E, Ristimäki A, Taïeb A, Vapaatalo H, Lubitz W, Vaheri A.(#19020) from Cayman Chemical (Ann Arbor, MI, USA). Indomethacin (I7378) was from Sigma and the NS-398 (#70590) from Cayman Chemical. The cell-permeable caspase inhibitor ZVAD-FMK was from Calbiochem (San Diego,

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NS 398

NS 398

NS 398 from Cayman Chemical

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Cayman Chemical

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NS 398 from Cayman Chemical

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