Wy 14643 from Cayman Chemical

An agonist of PPARα; selectively transactivates PPARα over PPARγ in a reporter assay using CV-1 mouse fibroblasts at 100 µM; decreases distal colon protein levels of IFN-γ, TNF-α, IL-1β, and IL-6 in a mouse model of DSS-induced experimental colitis at 2 mg/kg; reduces hepatic triglycerides, leukocyte recruitment, and fibrosis in a mouse model of methionine- and choline-deficient diet-induced steatohepatitis at 0.1% w/w in the diet