Description
A GPR40 agonist and GPR120 partial agonist; induces intracellular calcium mobilization in cells expressing GPR40 or GPR120; induces ERK activation in cells expressing GPR40 or GPR120 at 100 µM; inhibits ATP citrate lyase (Kis = 40 and 200 µM for the oxidized and reduced enzyme, respectively); chronic dietary administration of MEDICA 16 (0.25% w/w) decreases liver ACC and AMPK levels in a model of insulin resistance using JCR:LA-cp rats; reduces plasma insulin levels, decreases fasting plasma triacylglycerol levels, and delays the onset of hyperinsulinemia in JCR:LA-cp rats at 0.25% w/w in the diet