T0901317 from Cayman Chemical

Product Specs
ItemT0901317
CompanyCayman Chemical
Price $137.00Supplier Page View Company Product Page
Catalog Number71810
Quantity50 mg
Research AreaCardiovascular System, Endocrinology & Metabolism, FXRs & LXRs, Hormones & Receptors, Lipids & Lipoproteins, RARs, RORs, & RXRs, Storage & Transport
FormatA crystalline solid
Molecular Weight481.3
Purity≥98%
Storage-20
FormulaC17H12F9NO3S
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signalingCell ReportsApril 22, 2025Allison Wing, Elise Jeffery, Christopher D. Church, Jennifer Goodell, Rocío del M. Saavedra-Peña, Moumita Saha, Brandon Holtrup, Maud Voisin, N. Sima Alavi, Mariana Floody, et al.(20:4),Cayman Chemical,90010 Docosahexaenoic acid (22:6),Cayman Chemical,90310 T0901317,Cayman Chemical,71810 BrdU,US Biological,B2850 Tamoxifen,Cayman,13258 Citrisolv,Decon Labs,1601 Fatty acid-free bovine

(2) Physiological activation of liver X receptor provides protection against ocular inflammation in uveitic glaucomaBiochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseJanuary 1, 2025Hyun Hee Ju, Jiyoung Lee, Seon-Kyu Kim, Seon-Young Kim, Jin-Hyun Ahn, Nikolai P. Skiba, Ponugoti V. Rao, Jin A. Choiimplicated in the pathobiology of glaucoma, namely: LXR agonist, T091317 (10 μM, 48 hours; cat no. 71810–10, Cayman Chemical, Ann Arbor, Michigan, USA), TGF-β1 (10 ng/ml, 24 hours; cat no. 240-B, R&D Systems,

(3) PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction networkStructureDecember 1, 2024Andrew D. Huber, Wenwei Lin, Shyaron Poudel, Darcie J. Miller, Taosheng Chenrecombinant proteins",, Dimethyl sulfoxide,Fisher Scientific,Cat#BP231-100 T0901317,Cayman Chemical,Cat#71810 Rifampicin,MilliporeSigma,Cat#R3501-5G SPA70,Lin et al.51,N/A dTAG-13,Tocris Bioscience,Cat#6605 dTAGV-1,Tocris

(4) Activation of LXR signaling ameliorates apoptosis of alveolar epithelial cells in Bronchopulmonary dysplasiaRespiratory ResearchNovember 7, 2024Yizhe Ma, Yameng Wang, Anni Xie, Luchun Wang, Yuqiong Zhang, Mingyan Tao, Xianhui Deng, Zhidan Bao, Renqiang YuPN14 (BPD + PBS group) and intraperitoneal injection with LXR agonist T0901317 (Cayman Chemical, Cat#71810) group (BPD + T09 group). Based on previous works, T0901317 was dissolved in DMSO and intraperitoneal

(5) Implications of GPIIB-IIIA Integrin and Liver X Receptor in Platelet-Induced Compression of Ovarian Cancer Multi-Cellular SpheroidsCancers (Basel)October 19, 2024Zitha Redempta Isingizwe, Virginie Sjoelund, Doris Mangiaracina Benbrooktransduced ES-2 cells after adding an LXR agonist, T0901317 or LXR antagonist, GSK2033 (Cayman Chemical, 71810, or 25443, respectively). Luciferase activity was measured after adding the luciferin substrate (PerkinElmer,

(6) Extracellular vesicle-associated cholesterol supports the regenerative functions of macrophages in the brainJ Extracell VesiclesDecember 20, 2023Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx, Flore Wouters, Koen Kuipers, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, et al.cat. #C4555, Sigma‐Aldrich) were used to inhibit specific EV uptake pathways. T0901317 (10 µM, cat. #71810, Cayman Chemicals) was used as LXR agonist. 2.2 Animals Wild‐type C57BL/6J mice were purchased from

(7) Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by derivatives of a promiscuous nuclear receptor ligandStructureDecember 1, 2023Andrew D. Huber, Shyaron Poudel, Yongtao Li, Wenwei Lin, Jing Wu, Darcie J. Miller, Taosheng Chenpurchased from Fisher Scientific (cat. # BP231-100). T0901317 was purchased from Cayman Chemical (cat. # 71810). Rosiglitazone (cat. # HY-17386) and GW0742 (cat. # HY-13928) were purchased from MedChemExpress. Organic

(8) Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor βBreast Cancer ResearchApril 14, 2023Yuko Murakami-Nishimagi, Kotaro Sugimoto, Makoto Kobayashi, Kazunoshin Tachibana, Manabu Kojima, Maiko Okano, Yuko Hashimoto, Shigehira Saji, Tohru Ohtake, Hideki ChibaFunakoshi), 1 mg/ml of Cholesterol-Water Soluble (C4951-30MG; Sigma-Aldrich), and 1–25 µM of T0901317 (71810, Cayman Chemical) 24 h after plating. C-CPE production and purification were performed as described

(9) LXRα Regulates oxLDL-Induced Trained Immunity in MacrophagesInternational journal of molecular sciencesMay 31, 2022Findeisen HM, Voges VC, Braun LC, Sonnenberg J, Schwarz D, Körner H, Reinecke H, Sohrabi Y.Bio-OneTM) and primed with 20 μg/mL oxLDL, 2 μM T0901317 (T1317, LXR agonist, Cayman, Ann Arbor, MI, USA, #71810), 2.5 μM GSK2033 (LXR antagonist, Cayman, Ann Arbor, MI, USA, #25443), 1 μM SR9238 (LXR inverse agonist,

(10) Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assayScientific ReportsFebruary 24, 2022Alexander Medvedev et al.85532-75-8, purity: ≥ 98%), Progesterone (CAT# 15876, CAS: 57-83-0, purity: ≥ 98%), T0901317 (CAT# 71810, CAS: 293754-55-9, purity: ≥ 98%), Troglitazone (CAT# 71750, CAS: 97322-87-7, purity: ≥ 98%), XCT790

(11) FoxO-KLF15 pathway switches the flow of macronutrients under the control of insuliniScienceDecember 17, 2021Takeuchi Y, Yahagi N, Aita Y, Mehrazad-Saber Z, Ho MH, Huyan Y, Murayama Y, Shikama A, Masuda Y, Izumida Y, et al.tube,Beckman coulter,349621 ALLN (Protease inhibitor),Calbiochem,208719 T0901317,Cayman Chemical,71810 40 μm mesh cell strainer,Corning,352340 Dithiothreitol (DTT),FUJIFILM Wako chemicals,040-29223 D-Luciferin

(12) Saringosterol from Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient MiceMarine drugsAugust 26, 2021Yan Y, Niu Z, Wang B, Zhao S, Sun C, Wu Y, Li Y, Ying H, Liu H.volume of phosphate-buffered saline (PBS). As a positive control, mice were treated with T0901317 (71810-50, Cayman, Ann Arbor, Michigan) and the doses were 50 mg/kg/day. At the end of the experiment, animals

(13) Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formationCell chemical biologyJune 17, 2021Hubler Z, Friedrich RM, Sax JL, Allimuthu D, Gao F, Rivera-León AM, Pleshinger MJ, Bederman I, Adams DJ.Chemicals,Cat#10009931 25-hydroxycholesterol,Cayman Chemicals,Cat#11097 T0901317,Cayman Chemicals,Cat#71810 GW 3965,Cayman Chemicals,Cat#10054 WAY252623,Cayman Chemicals,Cat# 21117 SR9238,Cayman Chemicals,Cat#

(14) Genetic and pharmacological inhibition of the nuclear receptor RORα regulates T(H)17 driven inflammatory disordersNature communicationsJanuary 4, 2021Wang R, Campbell S, Amir M, Mosure SA, Bassette MA, Eliason A, Sundrud MS, Kamenecka TM, Solt LA.reagents SR333536 and SR221140 have previously been described. T0901317 was purchased from Cayman Chemical (Cat. #71810) and Rifampicin was purchased from Chem-Impex International, Inc. (Cat. # 00260). Mouse in vitro CD4+

(15) Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestineThe Journal of Nutritional BiochemistryFebruary 1, 2020Hannah C. Lifsey, Rupinder Kaur, Bradley H Thompson, Lisa Bennett, Ryan E. Temel, Gregory A. Grafstigmasterol (Sigma-Aldrich, Product Number S2424) or 0.015% (w/w) T0901317 (Cayman Chemical, Product Code 71810). At 8 weeks of age, mice were singly housed with access to water and control diet for 3 days. On day

(16) LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human MonocytesFrontiers in immunologyJanuary 1, 2020Sohrabi Y, Sonntag GVH, Braun LC, Lagache SMM, Liebmann M, Klotz L, Godfrey R, Kahles F, Waltenberger J, Findeisen HM.cells/well in a 96-well plate (Greiner Bio-OneTM) with 2 μg/ml BCG, 2 μM T0901317 (T1317) (Cayman, #71810), 10 μM GW3965 (Cayman, #10054), 5 μM GSK2033 (Cayman, #25443), 500 μM acetyl-CoA (Cayman, # 16160)

(17) Chronic Activation of Liver X Receptor Sensitizes Mice to High Cholesterol Diet–Induced Gut ToxicityMolecular PharmacologyOctober 1, 2018Wojciech G. Garbacz, Hirdesh Uppal, Jiong Yan, Meishu Xu, Songrong Ren, Donna B. Stolz, Min Huang, Wen Xiecomposition by percentages of weight. For drug treatment, daily gavages of T0901317 (20 mg/kg) (cat. no. 71810; Cayman Chemical, Ann Arbor, MI), GW3965 (20 mg/kg) (cat. no. 10054, Cayman), or ezetimibe (10 mg/kg)

(18) Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's diseaseMolecular neurodegenerationMay 21, 2018Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, et al.#L4391, Escherichia coli 0111:B4). LXRα/β agonist T0901317 was obtained from Cayman Chemicals (Cat# 71810) and dissolved in DMSO and was diluted in saline prior to administration. Flow cytometric and immunohistochemistry

(19) RETRACTED ARTICLE: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancerNature CommunicationsDecember 1, 2017Anthony Alioui et al.coloration and immunohistochemistry. Reagents T0901317 ligand was purchased from Cayman Chemical (71810). Simvastatin (S6196), Doxycycline (D9891) and Vitamine E (T3376) were purchased from Sigma-Aldrich,

(20) Crosstalk between Thyroid Hormone Receptor and Liver X Receptor in the Regulation of Selective Alzheimer’s Disease Indicator-1 Gene ExpressionPLoS ONEJanuary 24, 2013Emi Ishida, Koshi Hashimoto, Shuichi Okada, Tetsurou Satoh, Masanobu Yamada, Masatomo Moriper 20 g body weight of T3 for 7 days [37]. For TO treatment, 1 mg per 20 g body weight of TO901317 (#71810 Cayman, Ann Arbor, MI) was intraperitoneally administered daily for 7 days [31], [33] or vehicle (DMSO)

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T0901317

T0901317

T0901317 from Cayman Chemical

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Cayman Chemical

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T0901317 from Cayman Chemical

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