Resolvin D1 from Cayman Chemical

Product Specs
ItemResolvin D1
CompanyCayman Chemical
Price $169.00Supplier Page View Company Product Page
Catalog Number10012554
FormatA 100 µg/ml solution in ethanol
Molecular Weight376.5
Purity≥95%
Storage-80
FormulaC22H32O5
OriginUSA
Quantity10 µg
Research AreaImmunology & Inflammation, Inflammatory Lipid Mediators, Innate Immunity, Lipid Biochemistry, Lipoxygenase Pathways, Specialized Pro-Resolving Mediators

Specifications/Features

Ki, IC, EC, or working concentration: EC50: 30 nM for Human polymorphonuclear leukocyte (PMNL) transendothelial migration

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Resolvin D1 in the Lipopolysaccharide-Induced Inflammatory Microenvironment Mediates Resolution in Human Monocytic THP-1 CellsBiomedicinesMay 15, 2026Zhe Xing, Qian Zhao, Xiaoli He, Jiazheng Cai, Yaxin Xue, Christopher Graham Fenton, Alpdogan Kantarci, Kristin Andreassen Fenton, Xiaoli An, Ying Xuea humidified atmosphere of 5% CO2 at 37 °C. 2.2. RvD1 Treatment and LPS Exposure RvD1 (catalog # 10012554) was obtained from Cayman Chemicals (Ann Arbor, MI, USA). Lipopolysaccharide (LPS, Escherichia coli

(2) Effects of specialized proresolving mediators on gut epithelial barrier in early lifeThe Journal of Pharmacology and Experimental TherapeuticsMarch 1, 2026Jing Chen, Sarah Ouahoud, Renee R.C.E. Schreurs, Sander Meisner, Jacqueline L.M. Vermeulen, Manon E. Wildenberg, Wouter J. de Jonge, Johannes B. van Goudoever, Tim G.J. de Meij, Vanesa Muncan, et al.preparation and handling LxA4, RvD1, and RvE1 were obtained from Cayman Chemical (item numbers 90410, 10012554, and 10007848; batch numbers 0614337-35, 0471528-244, and 0659583-2, respectively). Compounds were supplied

(3) Postpartum lipid dysregulation in African American women who experienced cardiometabolic complications of pregnancyiScienceDecember 19, 2025Kristal Maner-Smith, Chih-Yu Chen, Zhenxin Hou, Xueyun Liu Gulbin, Jun Ahn, Eric A. Ortlund, Anne L. Dunlop, Erin Ferranti,Cayman Chemical,#38410 Resolvin D3,Cayman Chemical,#13834 Resolvin E1,Cayman Chemical,#10007848 Resolvin D1,Cayman Chemical,#10012554 Resolvin D2,Cayman Chemical,#10007279 ,, Deposited data,Deposited data,Deposited data ,, Identified

(4) Resolvin D1 alleviates lipopolysaccharide-induced in vitro corneal inflammation by modulating macrophage polarization through upregulation of c-Fos expressionBioImpactsNovember 15, 2025Qin Qin, Yinru Wang, Yajun Liu, Weiwei An, Zifang He, Feifei Chen, Xinxuan Cheng, Deyan Chen, Zhenggao Xiestrategies for the management of bacterial keratitis. Materials and Methods Reagents RvD1 (Cat#: 10012554) was supplied by Cayman Chemical (Michigan, USA). IL-4 (Cat#: 200-04 and 214-14) was obtained from PeproTech

(5) Immunological response and tissue loss in a rodent model of chronic traumatic brain injury treated with resolvinJ Inflamm (Lond)October 2, 2025Olivia Kiwanuka, Julie Cheung, Anders Hånell, Caroline Lindbladintraperitoneal injection of either sterile saline (S) or RvD1 (RvD1) (Cayman Chemical, US, Item No. 10012554, 10 µg) for 3 consecutive weeks before sacrifice. RvD1 was handled in order with the manufacturer’s

(6) Resolvin D1–mediated cellular crosstalk protects against MASHJHEP ReportsMay 14, 2025Amaia Navarro-Corcuera, Yiwei Zhu, Fanglin Ma, Neha Gupta, Haley Asplund, Bruno Cogliati, Jerry E. Chipuk, Oren Rom, Scott L. Friedman, Brian E. Sansbury, et al.intraperitoneally injected with 200 μl sterile PBS (vehicle) or RvD1 (500 ng/mouse, Cayman Chemical, #10012554, Ann Arbor, MI, USA) three times per week for 5 additional weeks while still on the FAT-MASH diet. The

(7) Therapeutic Activity of Resolvin D1 (RvD1) in Murine MASHbioRxivNovember 18, 2024Amaia Navarro-Corcuera, Yiwei Zhu, Fanglin Ma, Neha Gupta, Haley Asplund, Feifei Yuan, Scott Friedman, Brian E. Sansbury, Xin Huang, Bishuang Caiintraperitoneally injected with 200 mL of sterile PBS (vehicle) or RvD1 (500 ng/mouse, Cayman Chemical, #10012554) three times per week for five additional weeks while still on the FAT-MASH diet. The animals received

(8) Resolvin D1 attenuates Ang II-induced hypertension in mice by inhibiting the proliferation, migration and phenotypic transformation of vascular smooth muscle cells by blocking the RhoA/mitogen-activated protein kinase pathwayJournal of hypertensionMarch 1, 2024Wei C, Zhang J, Peng S, Liu J, Xu Y, Zhao M, Xu S, Pan W, Yin Z, Zheng Z, et al.Enzo Life Sciences (ALX-151–039-M025, Farmingdale, New York, USA). RvD1 was purchased from Cayman Chemical (10012554, Ann Arbor, Michigan, USA). The RhoA agonist U46619 [16] was purchased from ApexBio Technology (B6890,

(9) Resolvin D1 promotes the resolution of inflammation in the ACLF rat model by increasing the proportion of Treg cellsImmunity, inflammation and diseaseNovember 1, 2023Chen L, Huang Y, Chen Y, Chen J, You X, Zou L, Chen J, Chen Z, Wang X, Huang Y.the acute hepatic injury; (3) low‐dose RvD1 group (RvD1‐L, n = 12): rats were ip injected with RvD1 (10012554; Cayman) 0.3 μg/kg 1 h before the induction of ALI; and (4) high‐dose RvD1 group (RvD1‐H, n = 12): rats

(10) Resolvin D1 prevents injurious neutrophil swarming in transplanted lungsProceedings of the National Academy of SciencesAugust 1, 2023Wenjun Li, Hailey M. Shepherd, Yuriko Terada, Ashley E. Shay, Amit I. Bery, Andrew E. Gelman, Kory J. Lavine, Charles N. Serhan, Daniel Kreiselintravenous administration of RvD1 (200 ng/per mouse in 200 µL 1% ethanol, Cayman Chemical Company, #10012554) or vehicle immediately before transplantation. Targeted Liquid Chromatography Tandem Mass Spectrometry. Lung

(11) Lung Inflammation Resolution by RvD1 and RvD2 in a Receptor-Dependent MannerPharmaceuticsMay 18, 2023Gao J, Su Y, Wang Z.therapeutic in treating inflammatory diseases. 2. Materials and Methods 2.1. Materials RvD1 and RvD2 (10012554, 10007279) were purchased from Cayman (Ann Arbor, MI, USA). Dimethyl sulfoxide (D4540, DMSO), lipopolysaccharide

(12) Radiation-Induced Macrophage Senescence Impairs Resolution Programs and Drives Cardiovascular InflammationJournal of immunology (Baltimore, Md. : 1950)October 1, 2021Sadhu S, Decker C, Sansbury BE, Marinello M, Seyfried A, Howard J, Mori M, Hosseini Z, Arunachalam T, Finn AV, et al.mouse. For RvD1 treatment studies, mice were i.p. injected with 300 ng of RvD1 (Cayman Chemical, Cat# 10012554) and 200 μg of ZymA simultaneously and peritoneal exudates were collected by lavage 24 hrs post injection.

(13) Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodelingAging CellJune 2, 2021James F. Markworth, Lemuel A. Brown, Eunice Lim, Jesus A. Castor‐Macias, Jacqueline Larouche, Peter C. D. Macpherson, Carol Davis, Carlos A. Aguilar, Krishna Rao Maddipati, Susan V. Brooksaccess to food and water. 4.3 Immunoresolvent treatment RvD1 was purchased from Cayman Chemicals (10012554). Aged mice were randomized to receive daily 100 µl intraperitoneal (IP) injections of either 100 ng

(14) Resolvin D1 Enhances Necroptotic Cell Clearance Through Promoting Macrophage Fatty Acid Oxidation and Oxidative PhosphorylationArteriosclerosis, Thrombosis, and Vascular BiologyMarch 1, 2021Zeinab Hosseini, Michael Marinello, Christa Decker, Brian E. Sansbury, Sudeshna Sadhu, Brennan D. Gerlach, Ramon Bossardi Bossardi Ramos, Alejandro P. Adam, Matthew Spite, Gabrielle FredmanFBS. The following day cells were treated with vehicle or 10 nmol/L RvD1 (Cayman Chemical, Catalog No. 10012554) for 20 minutes (37 °C, 5% CO2). PKH67-labeled NCs were then added in a 1:2 ratio (BMDM:NC) for an additional

(15) Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cellsJCI insightSeptember 17, 2020Markworth JF, Brown LA, Lim E, Floyd C, Larouche J, Castor-Macias JA, Sugg KB, Sarver DC, Macpherson PC, Davis C, et al.indicated within figure legends. Immunoresolvent treatment. RvD1 was purchased from Cayman Chemicals (10012554). Single-use aliquots of RvD1 were prepared in amber glass vials (Thermo Fisher Scientific, C4010-88AW),

(16) Resolvin D1 Administration Is Beneficial in Trypanosoma cruzi InfectionInfection and ImmunityMay 20, 2020Aline L. Horta, Tere Williams, Bing Han, Yanfen Ma, Ana Paula J. Menezes, Vincent Tu, André Talvani, Louis M. Weiss, Huan Huang(7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid) was purchased from Cayman Chemical (catalog no. 10012554; Cayman Chemical, Ann Arbor, MI). It was diluted in phosphate buffer to a ﬁnal concentration of 3 ␮g/kg

(17) Inhibition of lung cancer growth and metastasis by DHA and its metabolite, RvD1, through miR-138-5p/FOXC1 pathwayJournal of experimental & clinical cancer research : CRNovember 29, 2019Bai X, Shao J, Zhou S, Zhao Z, Li F, Xiang R, Zhao AZ, Pan J.Roche Diagnostics (#04913914001, Indianapolis, IN, USA). Resolvin D1 (RvD1) was obtained from Cayman Chemical Co. (#10012554, Ann Arbor, Michigan, USA). The following were commercially obtained antibodies: the anti-Akt (#9272),

(18) Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5Science advancesNovember 1, 2019Zhou Y, Lei J, Xie Q, Wu L, Jin S, Guo B, Wang X, Yan G, Zhang Q, Zhao H, et al.(5S,6R,15S-TriHETE; catalog no. 90410, Cayman Chemical), 10 nM RvD1 (7S,8R,17S-TriHETE; catalog no. 10012554, Cayman Chemical), 10 nM RvD2 (7S,16R,17S-TriHETE; catalog no. 10007279, Cayman Chemical), 1 μM baicalein

(19) Cholesterol crystals promote endothelial cell and monocyte interactions via H(2)O(2)-mediated PP2A inhibition, NFκB activation and ICAM1 and VCAM1 expressionRedox biologyJune 1, 2019Pichavaram P, Mani AM, Singh NK, Rao GN.Cytostatin (19602), pyrrolidinedithiocarbamic acid (PDTC) (20713), QNZ (10006734) and Resolvin D1 (10012554) were purchased from Cayman Chemical Company, (Ann Arbor, MI). Anti-pIκBα (2859) and anti-pNFκB (3033)

(20) Cholesterol crystals increase vascular permeability by inactivating SHP2 and disrupting adherens junctionsFree radical biology & medicineAugust 1, 2018Mani AM, Chattopadhyay R, Singh NK, Rao GN.(SC-23948) antibodies were purchased from Santa Cruz Biotechnology Inc., (Santa Cruz, CA). Resolvin D1 (10012554) was obtained from Cayman Chemical Company (Ann Arbor, MI). Fluorescein isothiocyanate-dextran (FD70S)

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Resolvin D1

Resolvin D1

Resolvin D1 from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

Citations (24)

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Resolvin D1 from Cayman Chemical

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