Description
A rotenoid with diverse biological activities; inhibits mitochondrial complex I activity in bovine heart electron transport particles and phorbol 12-myristate 13-acetate-induced ODC activity in MCF-7 cells (IC50s = 6.9 and 11 nM, respectively); induces apoptosis in MCF-7 and SK-BR-3 cells at 100 nM; induces mortality in adult bruchid beetles (C. maculatus) from 10-500 ppm; induces nigrostriatal dopaminergic degeneration in rats at 6 mg/kg