5-Iodotubercidin from Cayman Chemical

Description

An adenosine kinase inhibitor (IC50 = 0.026 µM); inhibits PKA, phosphorylase kinase, CK1, CK2, and PKC (IC50s = 5-10, 5-10, 0.4, 10.9, and 0.4 µM, respectively); inhibits SARS-CoV-2 RdRp (EC50 = 0.75 µM); decreases fatty acid synthesis and increases fatty acid oxidation in isolated rat hepatocytes at 20 µM; reduces the number of seizures in a rat model of MES-induced seizures (ED50 = 6 mg/kg)

Product Specs
Item5-Iodotubercidin
CompanyCayman Chemical
Price $117.00Supplier Page View Company Product Page
Catalog Number10010375
Research AreaCell Biology, Cell Signaling, Coronaviruses, COVID-19, Epigenetics, Transcription, & Translation, Immunology & Inflammation, Infectious Disease, Neuroscience, Pulmonary Diseases, RNA, DNA, & Protein Synthesis, Seizure Disorders, Viral Diseases
FormatA solid
Molecular Weight392.2
Purity≥95%
Storage-20
FormulaC11H13IN4O4
OriginCHN
TypeInhibitors
Quantity1 mg

Specifications/Features

Ki, IC, EC, or working concentration: PKA: IC50 = 5-10 µM
Phosphorylase kinase: IC50 = 5-10 µM
Casein kinase I: IC50 = 0.4 µM
Casein Kinase II: IC50 = 10.9 µM
PKC: IC50 = 0.4 µM)
ERK2: Ki = 525 nM

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Meiosis-specific distal cohesion site decoupled from the kinetochoreNat CommunMarch 3, 2025Bo Pan, Melania Bruno, Todd S. Macfarlan, Takashi AkeraExpress, cat# HY-103020), at 10 µM; Haspin inhibitor, 5-iodotubercidin (5-Itu) (Cayman Chemical, cat# 10010375), at 0.5 or 1 µM; PP2A inhibitor, Okadaic acid (Sigma-Aldrich, cat# O9381-25UG), at 10 nM. Oocyte microinjection Nuclear envelope

(2) NRH salvage and conversion to NAD⁺ requires NRH kinase activity by adenosine kinaseNature metabolismApril 1, 2020Yang Y, Zhang N, Zhang G, Sauve AA.inhibitors for AK, 5-Iodotubercidin (5-Itu) and ABT702 dihydrochloride were purchased from Cayman Chemical (#10010375) and Tocris Bioscience (#2372) respectively. To test if these compounds can interfere with the NRH-induced

(3) HASPIN kinase mediates histone deacetylation to regulate oocyte meiotic maturation in pigsReproductionJune 1, 2019Zubing Cao et al.University. Preparation of HASPIN inhibitor 5-Itu HASPIN inhibitor 5-iodotubercidin (5-Itu) (Cayman Chemical, cat no. 10010375) was dissolved in 100% ethanol. Oocyte maturation medium was used to dilute the 5-Itu stock solution to

(4) Haspin inhibition reveals functional differences of interchromatid axis-localized AURKB and AURKCMolecular biology of the cellAugust 15, 2017Quartuccio SM, Dipali SS, Schindler K.After 2 h of maturation, oocytes failing to undergo nuclear envelope breakdown were discarded. 5-Itu (10010375; Cayman Chemical, Ann Arbor, MI) was dissolved in 100% ethanol and diluted in CZB at 1:1000. To inhibit

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