U-18666A from Cayman Chemical

Product Specs
ItemU-18666A
CompanyCayman Chemical
Price $98.00Supplier Page View Company Product Page
Catalog Number10009085
Quantity10 mg
Research AreaCardiovascular System, Lipid Biochemistry, Lipid Transport, Lipids & Lipoproteins, Neuroscience, Sterol Lipids, Storage & Transport
FormatA crystalline solid
Molecular Weight424.1
Purity≥95%
Storage-20
FormulaC25H41NO2 • HCl
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Plasma membrane accessible cholesterol is regulated by ACC1 and lipid dropletsbioRxivAugust 31, 2025Kalani M. Wijesinghe, Chai-wan Kim, Emily O. Schad, Shuo Li, Summer Chen, Erin Takeshima, Chandni B. Khandwala, Desiree Tillo, Andres M. Lebensohn, James A. Olzmann, et al.Cayman Chemical), the LXR inhibitor GSK2033 (1 μM) (25443, Cayman Chemical), the NPC1 inhibitor U18666A (1 μM) (10009085, Cayman Chemical) the ACC1 inhibitor Firsocostat (also named GS-0976 and ND-630) (30 μM) (HY-16901,

(2) ATG16L1 WD domain and linker regulates lipid trafficking to maintain plasma membrane integrity to limit influenza virus infectionAutophagyApril 3, 2025Benjamin Bone, Luke Griffith, Matthew Jefferson, Yohei Yamauchi, Thomas Wileman, Penny P. Powellat concentrations of 25 mg per kilogram of body weight. In tissue culture, U18666A (Cayman Chemical,10009085) was used at 3 µg/mL for 24 hours. Cholesterol (Sigma-Aldrich, C8667) and 25-hydroxy cholesterol (25HC;

(3) Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitorsMolecular & Cellular OncologyDecember 31, 2024Takahito Fukui, Manami Yabumoto, Misuzu Nishida, Shiori Hirokawa, Riho Sato, Taichi Kurisu, Miyu Nakai, Md. Abul Hassan, Koji KishimotoCorporation. EBSS (E7510) and DMEM without glucose (A1443001) were purchased from Sigma-Aldrich. U18666A (10009085) and ConA (11050) were purchased from Cayman Chemical. We purchased 2-deoxy-D-glucose (2-DG) from Nacalai

(4) Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levelsmBioMarch 13, 2024Zeng Q, Antia A, Casorla-Perez LA, Puray-Chavez M, Kutluay SB, Ciorba MA, Ding S.(Enzo Life Sciences, ALX-380-034-C025), tetrandrine (Selleckchem, S2403), U18666A (Cayman Chemical, 10009085), ETP-46464 (Selleckchem, S8050), JIB-04 (Tocris, 4972), nitazoxanide (COVID Box, MMV688991), ketoconazole

(5) SREBP activation contributes to fatty acid accumulations in necroptosis†RSC Chemical BiologyApril 5, 2023Daniel Lu, Laura R. Parisi, Omer Gokcumen, G. Ekin Atilla-Gokcumen#210-TA/CF). Atorvastatin (Cat # 10493). BIBB 515 (Cat # 10010517), Ro48-8071 (Cat # 10006415), U18666A (Cat # 10009085), Betulin (Cat # 11041), necrosulfonamide (Cat # 20844) and filipin III (Cat # 70440) were obtained

(6) Cholesterol content regulates silica-induced lysosomal membrane permeabilityFrontiers in ToxicologyFebruary 13, 2023Matthew J. Sydor, Rebekah L. Kendall, Andrij Holianmeasurements was Di-4-ANEPPDHQ, which was purchased from ThermoFisher (Waltham, MA). U18666a (Item No. 10009085) was obtained from Cayman Chemical (Ann Arbor, MI). The fluorescent substrate for n-acetyl-β-glucosaminidase

(7) Cellular cholesterol licenses Legionella pneumophila intracellular replication in macrophagesMicrobial CellJanuary 2, 2023Edna Ondari, Ashley Wilkins, Brian Latimer, Ana-Maria Dragoi, Stanimir S. Ivanovdescribed [79]. Reagents The following reagents were purchased from Cayman Chemicals - u18666A (cat #10009085), ketoconazole (cat #15212), Filipin III (cat #70440), NileRed (cat # 30787). Gemcitabine (cat #G6423)

(8) Sterol dysregulation in Smith-Lemli-Opitz syndrome causes astrocyte immune reactivity through microglia crosstalkDisease models & mechanismsDecember 1, 2022Freel BA, Kelvington BA, Sengupta S, Mukherjee M, Francis KR.(5 µM; DHCR7 inhibitor; Cayman Chemical, 14611), U18666A (20 nM; DHCR24 inhibitor; Cayman Chemical, 10009085) and atorvastatin (2.5 µM; HMG-CoA reductase inhibitor; Cayman Chemical, 10493). All comparisons for

(9) Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During Eimeria bovis Macromeront FormationFrontiers in Cellular and Infection MicrobiologyFebruary 11, 2022Liliana M. R. Silva, Zahady D. Velásquez, Sara López-Osorio, Carlos Hermosilla, Anja TaubertAdditionally, progesterone (25–75 µM; Sigma-Aldrich, P0130) and U18666A (7.5 µM; Cayman Chemical Company, 10009085) were used, which are both known to block intracellular sterol transport and release from endosomes.

(10) Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosisCell ReportsNovember 16, 2021Ruthellen H. Anderson, Kem A. Sochacki, Harika Vuppula, Brandon L. Scott, Elizabeth M. Bailey, Maycie M. Schultz, Jason G. Kerkvliet, Justin W. Taraska, Adam D. Hoppe, Kevin R. Francisand recombinant proteins",, AY9944,Cayman Chemical,Item No. 14611 U-18666A,Cayman Chemical,Item No. 10009085 Atorvastatin,Cayman Chemical,Item No. 10493 Simvastatin,Cayman Chemical,Item No. 10010344 methyl-β-cyclodextrin

(11) Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosisThe Journal of biological chemistryOctober 1, 2021Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E.for 40 h. For cholesterol-depletion studies, HUVECs were treated with 1 μM U18666A (Cayman Chemicals #10009085), 0.3% HPCD (#H107), or 50 μM MCD for the indicated times. For inflammation studies, HUVECs were treated

(12) Mevalonate Pathway-mediated ER Homeostasis Is Required for Haploid Stability in Human Somatic CellsCell Structure and FunctionFebruary 19, 2021Kan Yaguchi, Kimino Sato, Koya Yoshizawa, Daisuke Mikami, Kohei Yuyama, Yasuyuki Igarashi, Gabor Banhegyi, Eva Margittai, Ryota Ueharacompounds Compounds were purchased from suppliers as follows: Pitavasta‐ tin (163-24861, Wako); U18666A (10009085, Cayman Chemi‐ cal); Cholesterol (SLBZ0657, Sigma-Aldrich); FTI-277 (S7465, Selleck); GGTI-298 (S7466,

(13) Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2Proceedings of the National Academy of SciencesAugust 25, 2020Yuan-Lin Kang et al.gift from N. Gray, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (33), U-18666A (10009085) and Filipin III (70440) were from Cayman Chemical, Bafilomycin A1 (B1793-2UG) was from Sigma-Aldrich,

(14) Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseaseseLifeFebruary 18, 2019Yambire KF, Fernandez-Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, Raimundo N.(Biotrend, BG0162), 5 µM Sew2871 (Cayman, 10006440), 20 µM U0126 (Millipore, 662005), 10 µM U18666A (Cayman, 10009085), 10 µM W146 (Sigma-Aldrich, W1020), 2 µM FTY720 (Selleckchem, S5002) and 4 µM Staurosporine (Sigma-Aldrich,

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U-18666A

U-18666A

U-18666A from Cayman Chemical

Description

Cayman Chemical

Citations (14)

Reviews

U-18666A from Cayman Chemical

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